Art

J-GLOBAL ID：201402260704462690   Reference number：14A1175294

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

ゲノム編集および癌モデル化のためのCRISPR-Cas9ノックインマウス

Author (40)： PLATT Randall J. (Broad Inst. of MIT and Harvard, Cambridge, MA 02142, USA) ,  PLATT Randall J. (McGovern Inst. for Brain Res., Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  PLATT Randall J. (Dep. of Brain and Cognitive Sciences, Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  PLATT Randall J. (Dep. of Biological Engineering, Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  CHEN Sidi (David H. Koch Inst. for Integrative Cancer Res., Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  CHEN Sidi (Dep. of Biology, Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  ZHOU Yang (McGovern Inst. for Brain Res., Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  ZHOU Yang (Dep. of Brain and Cognitive Sciences, Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  YIM Michael J. (Broad Inst. of MIT and Harvard, Cambridge, MA 02142, USA) ,  YIM Michael J. (McGovern Inst. for Brain Res., Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  YIM Michael J. (Dep. of Brain and Cognitive Sciences, Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  YIM Michael J. (Dep. of Biological Engineering, Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  SWIECH Lukasz (Broad Inst. of MIT and Harvard, Cambridge, MA 02142, USA) ,  SWIECH Lukasz (McGovern Inst. for Brain Res., Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  SWIECH Lukasz (Dep. of Brain and Cognitive Sciences, Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  SWIECH Lukasz (Dep. of Biological Engineering, Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  KEMPTON Hannah R. (Broad Inst. of MIT and Harvard, Cambridge, MA 02142, USA) ,  KEMPTON Hannah R. (McGovern Inst. for Brain Res., Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  KEMPTON Hannah R. (Dep. of Biological Engineering, Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  DAHLMAN James E. (David H. Koch Inst. for Integrative Cancer Res., Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  DAHLMAN James E. (Harvard-MIT Div. of Health Sciences and Technol., Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  DAHLMAN James E. (Inst. for Medical Engineering and Sci., Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  PARNAS Oren (Broad Inst. of MIT and Harvard, Cambridge, MA 02142, USA) ,  EISENHAURE Thomas M. (Broad Inst. of MIT and Harvard, Cambridge, MA 02142, USA) ,  EISENHAURE Thomas M. (Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA 02129, USA) ,  JOVANOVIC Marko (Broad Inst. of MIT and Harvard, Cambridge, MA 02142, USA) ,  GRAHAM Daniel B. (Broad Inst. of MIT and Harvard, Cambridge, MA 02142, USA) ,  JHUNJHUNWALA Siddharth (David H. Koch Inst. for Integrative Cancer Res., Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  HEIDENREICH Matthias (Broad Inst. of MIT and Harvard, Cambridge, MA 02142, USA) ,  HEIDENREICH Matthias (McGovern Inst. for Brain Res., Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  HEIDENREICH Matthias (Dep. of Brain and Cognitive Sciences, Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  HEIDENREICH Matthias (Dep. of Biological Engineering, Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  XAVIER Ramnik J. (Broad Inst. of MIT and Harvard, Cambridge, MA 02142, USA) ,  LANGER Robert (David H. Koch Inst. for Integrative Cancer Res., Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  LANGER Robert (Harvard-MIT Div. of Health Sciences and Technol., Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  LANGER Robert (Inst. for Medical Engineering and Sci., Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  LANGER Robert (Dep. of Chemical Engineering, Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  ANDERSON Daniel G. (David H. Koch Inst. for Integrative Cancer Res., Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  ANDERSON Daniel G. (Harvard-MIT Div. of Health Sciences and Technol., Massachusetts Inst. of Technol., Cambridge, MA 02139, USA) ,  ANDERSON Daniel G. (Inst. for Medical Engineering and Sci., Massachusetts Inst. of Technol., Cambridge, MA 02139, USA)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 159  Issue： 2  Page： 440-455  Publication year： Oct. 09, 2014 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： Mus musculus ,  *gene expression ,  gene manipulation ,  RNA ,  RNA Editing ,  vector (genetics) ,  ras gene ,  p53 gene ,  tumor suppressor gene ,  gene introduction ,  *experimental disease ,  *tumorigenesis ,  *CRISPR-Cas Systems ,  K-ras gene ,  knock-in mouse ,  expression vector ,  STK11 gene ,  RNA, Guide ,  Myomorpha ,  *molecular genetic phenomenon
Semi thesaurus term： *tumorigenesis ,  LKB1 gene ,  RNA, Guide ,  gene delivery

JST classification (3)： Laboratry organisms  (EA03070Y) ,  Gene manipulation  (EC02050B) ,  Carcinogenic mechanisms and factors  (GE02020C)

Terms in the title (5)： ゲノム編集 ,  癌 ,  モデル化 ,  CRISPR-Cas9 ,  ノックインマウス