Art

J-GLOBAL ID：201402260972475959   Reference number：14A1050269

Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer

変異型IDHはHNF-4αを抑制して肝細胞の分化を阻害し胆道がんを促進する

Author (31)： SAHA Supriya K. (Harvard Medical School, Massachusetts, USA) ,  PARACHONIAK Christine A. (Harvard Medical School, Massachusetts, USA) ,  GHANTA Krishna S. (Harvard Medical School, Massachusetts, USA) ,  FITAMANT Julien (Harvard Medical School, Massachusetts, USA) ,  ROSS Kenneth N. (Harvard Medical School, Massachusetts, USA) ,  NAJEM Mortada S. (Harvard Medical School, Massachusetts, USA) ,  GURUMURTHY Sushma (Harvard Medical School, Massachusetts, USA) ,  DESHPANDE Vikram (Harvard Medical School, Massachusetts, USA) ,  ZHU Andrew X. (Harvard Medical School, Massachusetts, USA) ,  FERRONE Cristina R. (Harvard Medical School, Massachusetts, USA) ,  RAMASWAMY Sridhar (Harvard Medical School, Massachusetts, USA) ,  BARDEESY Nabeel (Harvard Medical School, Massachusetts, USA) ,  AKBAY Esra A. (Harvard Medical School, Massachusetts, USA) ,  WONG Kwok-Kin (Harvard Medical School, Massachusetts, USA) ,  SIA Daniela (Univ. Barcelona, Catalonia, ESP) ,  CORNELLA Helena (Univ. Barcelona, Catalonia, ESP) ,  LLOVET Josep M. (Univ. Barcelona, Catalonia, ESP) ,  SIA Daniela (Icahn School of Medicine at Mount Sinai, New York, USA) ,  MILTIADOUS Oriana (Icahn School of Medicine at Mount Sinai, New York, USA) ,  LLOVET Josep M. (Icahn School of Medicine at Mount Sinai, New York, USA) ,  SIA Daniela (National Cancer Inst., Milan, ITA) ,  WALESKY Chad (Univ. Kansas Medical Center, Kansas, USA) ,  APTE Udayan (Univ. Kansas Medical Center, Kansas, USA) ,  HEZEL Aram F. (Univ. Rochester Medical Center, New York, USA) ,  YEN Katharine E. (Agios Pharmaceuticals, Massachusetts, USA) ,  STRALEY Kimberly S. (Agios Pharmaceuticals, Massachusetts, USA) ,  TRAVINS Jeremy (Agios Pharmaceuticals, Massachusetts, USA) ,  POPOVICI-MULLER Janeta (Agios Pharmaceuticals, Massachusetts, USA) ,  GLISER Camelia (Agios Pharmaceuticals, Massachusetts, USA) ,  LLOVET Josep M. (Institutetucio Catalana de Recerca i Estudis Avancats, Catalonia, ESP) ,  RAMASWAMY Sridhar (Broad Inst. of Harvard and MIT, Massachusetts, USA)
Material： Nature (London)  (Nature (Lond))
Volume： 513  Issue： 7516  Page： 110-114  Publication year： Sep. 04, 2014 
JST Material Number： D0193B  ISSN： 0028-0836  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： DNA binding protein ,  *transcription factor ,  *isocitrate dehydrogenase ,  hepatocyte ,  cell differentiation ,  *biliary tract neoplasm ,  mutation ,  transgenic mouse ,  Ras protein ,  experimental disease ,  metastasis ,  carcinogenesis
Semi thesaurus term： *HNF-4 alpha ,  K-ras

JST classification (2)： Carcinogenic mechanisms and factors  (GE02020C) ,  Enzyme physiology  (EJ02020P)

Substance index (1)： 2-Hydroxyglutaric acid

Terms in the title (7)： 変異型 ,  HNF-4α ,  肝細胞 ,  分化 ,  阻害 ,  胆道がん ,  促進