Art

J-GLOBAL ID：201402268132538020   Reference number：14A1146429

Quinine Compared to 4β-Hydroxycholesterol and Midazolam as Markers for CYP3A Induction by Rifampicin

リファンピシンによるCYP3A誘導のマーカーとしての4β-ヒドロキシコレステロールおよびミダゾラムと比較したキニン

Author (10)： BJOERKHEM-BERGMAN Linda (Clinical Pharmacology, Dep. of Lab. Medicine, Karolinska Institutet, Karolinska Univ. Hospital Huddinge) ,  BJOERKHEM-BERGMAN Linda (Clinical Microbiology, Dep. of Lab. Medicine, Karolinska Institutet, Karolinska Univ. Hospital Huddinge) ,  BAECKSTROEM Tobias (Clinical Pharmacology, Dep. of Lab. Medicine, Karolinska Institutet, Karolinska Univ. Hospital Huddinge) ,  NYLEN Hanna (Clinical Chemistry, Dep. of Lab. Medicine, Karolinska Institutet, Karolinska Univ. Hospital Huddinge) ,  ROENQUIST-NII Yuko (Clinical Pharmacology, Dep. of Lab. Medicine, Karolinska Institutet, Karolinska Univ. Hospital Huddinge) ,  BREDBERG Eva (Astra Zeneca, R&D Moelndal) ,  ANDERSSON Tommy B. (Astra Zeneca, R&D Moelndal) ,  ANDERSSON Tommy B. (Section of Pharmacogenetics, Dep. of Physiology and Pharmacology, Karolinska Institutet) ,  BERTILSSON Leif (Clinical Pharmacology, Dep. of Lab. Medicine, Karolinska Institutet, Karolinska Univ. Hospital Huddinge) ,  DICZFALUSY Ulf (Clinical Chemistry, Dep. of Lab. Medicine, Karolinska Institutet, Karolinska Univ. Hospital Huddinge)
Material： Drug Metabolism and Pharmacokinetics  (Drug Metab Pharmacokinet)
Volume： 29  Issue： 4  Page： 352-355 (J-STAGE)  Publication year： 2014 
JST Material Number： X0758A  ISSN： 1347-4367  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...

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JST classification (2)： Clinical biopharmacy  (GY01022L) ,  Interactions of drugs  (GV01070X)

Substance index (8)： 4β-Hydroxycholesterol ,  Quinine ,  Midazolam ,  Rifampin ,  Cholesterol ,  6β-Hydroxycortisol ,  Cortisol ,  3-Hydroxyquinine

Reference (16)：

• 1) Backman, J. T., Olkkola, K. T., Ojala, M., Laaksovirta, H. and Neuvonen, P. J.: Concentrations and effects of oral midazolam are greatly reduced in patients treated with carbamazepine or phenytoin. Epilepsia, 37: 253-257 (1996).
• 2) Gerber, J. G., Rosenkranz, S. L., Fichtenbaum, C. J., Vega, J. M., Yang, A., Alston, B. L., Brobst, S. W., Segal, Y. and Aberg, J. A.: Effect of efavirenz on the pharmacokinetics of simvastatin, atorvastatin, and pravastatin: results of AIDS Clinical Trials Group 5108 Study. J. Acquir. Immune Defic. Syndr., 39: 307-312 (2005).
• 3) Pal, D. and Mitra, A. K.: MDR- and CYP3A4-mediated drug-drug interactions. J. Neuroimmune Pharmacol., 1: 323-339 (2006).
• 4) Björkhem-Bergman, L., Bäckström, T., Nylén, H., Rönquist-Nii, Y., Bredberg, E., Andersson, T. B., Bertilsson, L. and Diczfalusy, U.: Comparison of endogenous 4β-hydroxycholesterol with midazolam as markers for CYP3A4 induction by rifampicin. Drug Metab. Dispos., 41: 1488-1493 (2013).
• 5) Mirghani, R. A., Ericsson, O., Tybring, G., Gustafsson, L. L. and Bertilsson, L.: Quinine 3-hydroxylation as a biomarker reaction for the activity of CYP3A4 in man. Eur. J. Clin. Pharmacol., 59: 23-28 (2003).

Terms in the title (7)： リファンピシン ,  CYP3A ,  誘導 ,  マーカー ,  4β-ヒドロキシコレステロール ,  ミダゾラム ,  キニン