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J-GLOBAL ID：201402271605814854   Reference number：14A0954347

Hyper-O-GlcNAcylation Inhibits the Induction of Heat Shock Protein 70 (Hsp 70) by Sodium Arsenite in HeLa Cells

過度のO-GlcNAcylationはHeLa細胞において亜ヒ酸ナトリウムによる熱ショック蛋白質70(Hsp70)誘導を阻害する

Author (8)： MIURA Yuri (Res. Team for Mechanism of Aging, Tokyo Metropolitan Inst. of Gerontology) ,  SATO Takatoshi (Res. Team for Mechanism of Aging, Tokyo Metropolitan Inst. of Gerontology) ,  SATO Takatoshi (Dep. of Physics, School of Sci. and Technol., Meiji Univ.) ,  SAKURAI Yoko (Res. Team for Mechanism of Aging, Tokyo Metropolitan Inst. of Gerontology) ,  SAKAI Ryo (Res. Team for Mechanism of Aging, Tokyo Metropolitan Inst. of Gerontology) ,  SAKAI Ryo (Dep. of Physics, School of Sci. and Technol., Meiji Univ.) ,  HIRAOKA Wakako (Dep. of Physics, School of Sci. and Technol., Meiji Univ.) ,  ENDO Tamao (Res. Team for Mechanism of Aging, Tokyo Metropolitan Inst. of Gerontology)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 37  Issue： 8  Page： 1308-1314 (J-STAGE)  Publication year： 2014 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： genetic regulation ,...

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JST classification (3)： Cryptogenic diseases,other diseases in general  (GD07010X) ,  Cell physiology in general  (EF02010S) ,  Gene expression  (EC02040Q)

Reference (39)：

• 1) Hanover JA, Krause MW, Love DC. Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation. Nat. Rev. Mol. Cell Biol., 13, 312-321 (2012).
• 2) Naseem S, Parrino SM, Buenten DM, Konopka JB. Novel roles for GlcNAc in cell signaling. Commun. Integr. Biol., 5, 156-159 (2012).
• 3) Kim HS, Kim EM, Lee J, Yang WH, Park TY, Kim YM, Cho JW. Heat shock protein 60 modified with O-linked N-acetylglucosamine is involved in pancreatic beta-cell death under hyperglycemic conditions. FEBS Lett., 580, 2311-2316 (2006).
• 4) Bond MR, Hanover JA. O-GlcNAc cycling: A link between metabolism and chronic disease. Annu. Rev. Nutr., 33, 205-229 (2013).
• 5) Copeland RJ, Han G, Hart GW. O-GlcNAcomics-Revealing roles of O-GlcNAcylation in disease mechanisms and development of potential diagnostics. Proteomics Clin. Appl., 7, 597-606 (2013).

Terms in the title (6)： HeLa細胞 ,  亜ヒ酸ナトリウム ,  熱ショック蛋白質70 ,  HSP70 ,  誘導 ,  阻害