Art

J-GLOBAL ID：201402272510348356   Reference number：14A0127134

Synthesis and evaluation of novel benzimidazole derivatives as sirtuin inhibitors with antitumor activities

抗腫瘍活性を有するサーチュイン阻害剤である新規ベンゾイミダゾール誘導体の合成と評価

Author (9)： YOON Yeong Keng (Inst. for Res. in Molecular Medicine, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia) ,  ALI Mohamed Ashraf (Inst. for Res. in Molecular Medicine, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia) ,  ALI Mohamed Ashraf (New Drug Discovery Res., Dep. of Medicinal Chemistry, Alwar Pharmacy Coll., Alwar 301030, Rajasthan, IND) ,  ALI Mohamed Ashraf (New Drug Discovery Res., Dep. of Medicinal Chemistry, Sunrise Univ., Alwar 301030, Rajasthan, IND) ,  WEI Ang Chee (Inst. for Res. in Molecular Medicine, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia) ,  CHOON Tan Soo (Inst. for Res. in Molecular Medicine, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia) ,  OSMAN Hasnah (School of Chemical Sciences, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia) ,  PARANG Keykavous (Dep. of Biomedical and Pharmaceutical Sciences, Coll. of Pharmacy, Univ. of Rhode Island, Kingston, RI 02881, USA) ,  SHIRAZI Amir Nasrolahi (Dep. of Biomedical and Pharmaceutical Sciences, Coll. of Pharmacy, Univ. of Rhode Island, Kingston, RI 02881, USA)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 22  Issue： 2  Page： 703-710  Publication year： Jan. 15, 2014 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： histone deacetylase ,  enzyme inhibitor ,  nitrogen heterocyclic compound ,  polynuclear aromatic compound ,  *antitumor action ,  MCF7 cell ,  tumor cell ,  cultured cell ,  breast tumor
Semi thesaurus term： *HDAC inhibitor ,  MDA-MB-468 cell ,  Sirtuin 1 ,  Sirtuin 2 ,  *benzimidazoles

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Synthesis of drugs  (GV01030F)

Substance index (1)： 1-(2-Hydroxyethyl)-2-[4-(dimethylamino)phenyl]-1H-benzoimidazole-5-carboxylic acid ethyl ester

Terms in the title (5)： 抗腫瘍活性 ,  サーチュイン ,  阻害剤 ,  ベンゾイミダゾール誘導体 ,  評価