Art

J-GLOBAL ID：201402272565847548   Reference number：14A0853831

Gut Microbial Metabolism Drives Transformation of Msh2-Deficient Colon Epithelial Cells

腸内細菌の代謝はMsh2欠損大腸上皮細胞の形質転換を駆動する

Author (21)： BELCHEVA Antoaneta (Dep. of Immunology, Univ. of Toronto, Toronto, ON M5S 1A8, CAN) ,  IRRAZABAL Thergiory (Dep. of Immunology, Univ. of Toronto, Toronto, ON M5S 1A8, CAN) ,  ROBERTSON Susan J. (Dep. of Immunology, Univ. of Toronto, Toronto, ON M5S 1A8, CAN) ,  STREUTKER Catherine (Dep. of Lab. Medicine, St. Michael’s Hospital, Toronto, ON M5B 1W8, CAN) ,  MAUGHAN Heather (Ronin Inst., Montclair, NJ 07043, USA) ,  RUBINO Stephen (Dep. of Lab. Medicine and Pathobiology, Univ. of Toronto, Toronto, ON M5S 1A8, CAN) ,  MORIYAMA Eduardo H. (Princess Margaret Cancer Centre/University Health Network, Toronto, ON M5G 1L7, CAN) ,  COPELAND Julia K. (Centre for the Analysis of Genome Evolution & Function, Univ. of Toronto, Toronto, ON M5S 3B2, CAN) ,  KUMAR Sachin (Dep. of Immunology, Univ. of Toronto, Toronto, ON M5S 1A8, CAN) ,  GREEN Blerta (Dep. of Immunology, Univ. of Toronto, Toronto, ON M5S 1A8, CAN) ,  GEDDES Kaoru (Dep. of Immunology, Univ. of Toronto, Toronto, ON M5S 1A8, CAN) ,  PEZO Rossanna C. (Dep. of Medical Oncology, Univ. of Toronto, Toronto, ON M5S 1A8, CAN) ,  NAVARRE William W. (Dep. of Molecular Genetics, Univ. of Toronto, Toronto, ON M5S 1A8, CAN) ,  MILOSEVIC Michael (Dep. of Radiation Oncology, Princess Margaret Hospital, Toronto, ON M5G 2M9, CAN) ,  WILSON Brian C. (Princess Margaret Cancer Centre/University Health Network, Toronto, ON M5G 1L7, CAN) ,  GIRARDIN Stephen E. (Dep. of Lab. Medicine and Pathobiology, Univ. of Toronto, Toronto, ON M5S 1A8, CAN) ,  WOLEVER Thomas M.S. (Dep. of Nutritional Sciences, Univ. of Toronto, Toronto, ON M5S 3E2, CAN) ,  EDELMANN Winfried (Dep. of Cell Biology, Albert Einstein Coll. of Medicine, Bronx, NY 10461, USA) ,  GUTTMAN David S. (Centre for the Analysis of Genome Evolution & Function, Univ. of Toronto, Toronto, ON M5S 3B2, CAN) ,  PHILPOTT Dana J. (Dep. of Immunology, Univ. of Toronto, Toronto, ON M5S 1A8, CAN) ,  MARTIN Alberto (Dep. of Immunology, Univ. of Toronto, Toronto, ON M5S 1A8, CAN)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 158  Issue： 2  Page： 288-299  Publication year： Jul. 17, 2014 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： Mus musculus ,  colorectal neoplasm ,  experimental disease ,  tumor suppressor protein ,  *Microbiome ,  Metabolism ,  mismatch repair ,  DNA binding protein ,  DNA repair enzyme ,  oncoprotein ,  *intermolecular interaction ,  neoplastic cell transformation ,  epithelial cell ,  Cell Proliferation ,  *Carcinogenesis ,  pathological state ,  metabolite ,  catenin ,  transcription factor ,  beta Catenin ,  *gene-nutrient interaction ,  large intestinal epithelial cell ,  microbial metabolism ,  MutS Homolog 2 Protein ,  Mice, Mutant Strains ,  Adenomatous Polyposis Coli Protein ,  *intestinal flora ,  Myomorpha ,  differentiation (biology) ,  developmental physiology ,  Proteins
Semi thesaurus term： MSH2 protein ,  Mutant mice ,  APC protein ,  *intestinal flora

JST classification (3)： Basic medicine on digestive system  (GH01020E) ,  Carcinogenic mechanisms and factors  (GE02020C) ,  Metabolism and nutrition  (EG03054K)

Terms in the title (6)： 腸内細菌 ,  代謝 ,  MSH2 ,  欠損 ,  大腸上皮細胞 ,  形質転換