Art

J-GLOBAL ID：201402274900512672   Reference number：14A0652266

炎症とアルツハイマー病 非ステロイド系抗炎症薬とアルツハイマー病

Author (2)： HOSHINO TATSUYA (慶応大 薬) ,  MIZUSHIMA TOORU (慶応大 薬)
Material： Dementia Japan  (日本認知症学会誌)
Volume： 28  Issue： 2  Page： 199-204  Publication year： May. 15, 2014 
JST Material Number： X0596A  ISSN： 1342-646X  CODEN： DEJAFB  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： human(primates) ,...
Semi thesaurus term： COX2 ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=14A0652266&from=J-GLOBAL&jstjournalNo=X0596A") }}

JST classification (2)： Drug therapy(=pharmacotherapy)for nervous system diseases  (GN05020Y) ,  Clinical application of anti-inflammatory drugs  (GW15020E)

Substance index (3)： Dinoprostone ,  Donepezil ,  Memantine

Reference (13)：

• Akiyama H et al. (2000) Inflammation and Alzheimer's disease. Neurobiol Aging 21 : 383-421
• Eriksen JL, Sagi SA, Smith TE, Weggen S, Das P, McLendon DC, Ozols VV, Jessing KW, Zavitz KH, Koo EH, Golde TE (2003) NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. J Clin Invest 112: 440-449
• Green RC, Schneider LS, Amato DA, Beelen AP, Wilcock G, Swabb EA, Zavitz KH (2009) Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease : a randomized controlled trial. JAMA 302: 2557-2564
• Hoshino T, Namba T, Takehara M, Nakaya T, Sugimoto Y, Araki W, Narumiya S, Suzuki T, Mizushima T (2009) Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor. J Biol Chem 284: 18493-18502
• Hoshino T, Namba T, Takehara M, Murao N, Matsushima T, Sugimoto Y, Narumiya S, Suzuki T, Mizushima T (2012) Improvement of cognitive function in Alzheimer's disease model mice by genetic and pharmacological inhibition of the EP (4) receptor. J Neurochem 120: 795-805

Terms in the title (3)： 炎症 ,  アルツハイマー病 ,  非ステロイド系抗炎症薬