Art

J-GLOBAL ID：201402276236241596   Reference number：14A0237380

Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos

一細胞期胚のCas9/RNAターゲティングによる遺伝子改変カニクイザルの作製

Author (40)： NIU Yuyu (Yunnan Key Lab. of Primate Biomedical Res., Kunming 650500, CHN) ,  NIU Yuyu (Kunming Biomed International and National Engineering Res. Center of Biomedicine and Animal Sci., Kunming 650500, CHN) ,  SHEN Bin (MOE Key Lab. of Model Animal for Disease Study, Model Animal Res. Center of Nanjing Univ., National Resource Center ...) ,  CUI Yiqiang (State Key Lab. of Reproductive Medicine, Dep. of Histology and Embryology, Nanjing Medical Univ., Nanjing 210029, CHN) ,  CHEN Yongchang (Yunnan Key Lab. of Primate Biomedical Res., Kunming 650500, CHN) ,  CHEN Yongchang (Kunming Biomed International and National Engineering Res. Center of Biomedicine and Animal Sci., Kunming 650500, CHN) ,  WANG Jianying (MOE Key Lab. of Model Animal for Disease Study, Model Animal Res. Center of Nanjing Univ., National Resource Center ...) ,  WANG Lei (State Key Lab. of Reproductive Medicine, Dep. of Histology and Embryology, Nanjing Medical Univ., Nanjing 210029, CHN) ,  KANG Yu (Yunnan Key Lab. of Primate Biomedical Res., Kunming 650500, CHN) ,  KANG Yu (Kunming Biomed International and National Engineering Res. Center of Biomedicine and Animal Sci., Kunming 650500, CHN) ,  ZHAO Xiaoyang (State Key Lab. of Reproductive Biology, Inst. of Zoology, Chinese Acad. of Sciences, Beijing 100101, CHN) ,  SI Wei (Yunnan Key Lab. of Primate Biomedical Res., Kunming 650500, CHN) ,  SI Wei (Kunming Biomed International and National Engineering Res. Center of Biomedicine and Animal Sci., Kunming 650500, CHN) ,  LI Wei (State Key Lab. of Reproductive Biology, Inst. of Zoology, Chinese Acad. of Sciences, Beijing 100101, CHN) ,  XIANG Andy Peng (Center for Stem Cell Biology and Tissue Engineering, Key Lab. for Stem Cells and Tissue Engineering, Sun Yat-Sen ...) ,  ZHOU Jiankui (MOE Key Lab. of Model Animal for Disease Study, Model Animal Res. Center of Nanjing Univ., National Resource Center ...) ,  GUO Xuejiang (State Key Lab. of Reproductive Medicine, Dep. of Histology and Embryology, Nanjing Medical Univ., Nanjing 210029, CHN) ,  BI Ye (State Key Lab. of Reproductive Medicine, Dep. of Histology and Embryology, Nanjing Medical Univ., Nanjing 210029, CHN) ,  SI Chenyang (Yunnan Key Lab. of Primate Biomedical Res., Kunming 650500, CHN) ,  SI Chenyang (Kunming Biomed International and National Engineering Res. Center of Biomedicine and Animal Sci., Kunming 650500, CHN) ,  HU Bian (MOE Key Lab. of Model Animal for Disease Study, Model Animal Res. Center of Nanjing Univ., National Resource Center ...) ,  DONG Guoying (State Key Lab. of Reproductive Medicine, Dep. of Histology and Embryology, Nanjing Medical Univ., Nanjing 210029, CHN) ,  WANG Hong (Yunnan Key Lab. of Primate Biomedical Res., Kunming 650500, CHN) ,  WANG Hong (Kunming Biomed International and National Engineering Res. Center of Biomedicine and Animal Sci., Kunming 650500, CHN) ,  ZHOU Zuomin (State Key Lab. of Reproductive Medicine, Dep. of Histology and Embryology, Nanjing Medical Univ., Nanjing 210029, CHN) ,  LI Tianqing (Yunnan Key Lab. of Primate Biomedical Res., Kunming 650500, CHN) ,  LI Tianqing (Kunming Biomed International and National Engineering Res. Center of Biomedicine and Animal Sci., Kunming 650500, CHN) ,  TAN Tao (Yunnan Key Lab. of Primate Biomedical Res., Kunming 650500, CHN) ,  TAN Tao (Kunming Biomed International and National Engineering Res. Center of Biomedicine and Animal Sci., Kunming 650500, CHN) ,  PU Xiuqiong (Yunnan Key Lab. of Primate Biomedical Res., Kunming 650500, CHN) ,  PU Xiuqiong (Kunming Biomed International and National Engineering Res. Center of Biomedicine and Animal Sci., Kunming 650500, CHN) ,  WANG Fang (Yunnan Key Lab. of Primate Biomedical Res., Kunming 650500, CHN) ,  WANG Fang (Kunming Biomed International and National Engineering Res. Center of Biomedicine and Animal Sci., Kunming 650500, CHN) ,  JI Shaohui (Yunnan Key Lab. of Primate Biomedical Res., Kunming 650500, CHN) ,  JI Shaohui (Kunming Biomed International and National Engineering Res. Center of Biomedicine and Animal Sci., Kunming 650500, CHN) ,  ZHOU Qi (State Key Lab. of Reproductive Biology, Inst. of Zoology, Chinese Acad. of Sciences, Beijing 100101, CHN) ,  HUANG Xingxu (MOE Key Lab. of Model Animal for Disease Study, Model Animal Res. Center of Nanjing Univ., National Resource Center ...) ,  JI Weizhi (Yunnan Key Lab. of Primate Biomedical Res., Kunming 650500, CHN) ,  JI Weizhi (Kunming Biomed International and National Engineering Res. Center of Biomedicine and Animal Sci., Kunming 650500, CHN) ,  SHA Jiahao (State Key Lab. of Reproductive Medicine, Dep. of Histology and Embryology, Nanjing Medical Univ., Nanjing 210029, CHN)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 156  Issue： 4  Page： 836-843  Publication year： Feb. 13, 2014 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *Macaca fascicularis ,  laboratory animal ,  *gene targetting ,  embryo transfer ,  embryo ,  *gene expression ,  mRNA ,  RNA ,  RNA editing ,  gene ,  gynecotocological care
Semi thesaurus term： Cas9 mRNA ,  *CRISPR-Cas Systems ,  Macaca fascicularis ,  peroxisome proliferator activated receptor gamma gene ,  Genes, RAG-1 ,  RNA, Guide ,  One-cell embryo ,  Gene knockout

JST classification (2)： Laboratry organisms  (EA03070Y) ,  Gene manipulation  (EC02050B)

Terms in the title (8)： 細胞 ,  胚 ,  Cas9 ,  RNA ,  ターゲティング ,  遺伝子改変 ,  カニクイザル ,  作製