Art

J-GLOBAL ID：201402279796366768   Reference number：14A0064840

Rational design and synthesis of topoisomerase I and II inhibitors based on oleanolic acid moiety for new anti-cancer drugs

新規な抗癌剤のための,オレアノール酸分子団を基盤とするトポイソメラーゼIおよびII阻害剤の合理的設計および合成

Author (12)： ASHOUR Ahmed (Dep. of Agro-Environmental Sciences, Fac. of Agriculture, Kyushu Univ., Fukuoka, JPN) ,  ASHOUR Ahmed (Dep. of Pharmacognosy, Fac. of Pharmacy, Mansoura Univ., Mansoura, Egypt) ,  EL-SHARKAWY Saleh (Dep. of Pharmacognosy, Fac. of Pharmacy, Mansoura Univ., Mansoura, Egypt) ,  EL-SHARKAWY Saleh (Dep. of Pharmacognosy, Fac. of Pharmacy, Delta Univ. for Sci. and Technol., Egypt) ,  AMER Mohamed (Dep. of Pharmacognosy, Fac. of Pharmacy, Mansoura Univ., Mansoura, Egypt) ,  ABDEL BAR Fatma (Dep. of Pharmacognosy, Fac. of Pharmacy, Mansoura Univ., Mansoura, Egypt) ,  KATAKURA Yoshinori (Dep. of Genetic Resources Technol., Fac. of Agriculture, Kyushu Univ., Fukuoka, JPN) ,  MIYAMOTO Tomofumi (Graduate School of Pharmaceutical Sciences, Kyushu Univ., Fukuoka, JPN) ,  TOYOTA Nozomi (Dep. of Agro-Environmental Sciences, Fac. of Agriculture, Kyushu Univ., Fukuoka, JPN) ,  BANG Tran Hai (Dep. of Agro-Environmental Sciences, Fac. of Agriculture, Kyushu Univ., Fukuoka, JPN) ,  KONDO Ryuichiro (Dep. of Agro-Environmental Sciences, Fac. of Agriculture, Kyushu Univ., Fukuoka, JPN) ,  SHIMIZU Kuniyoshi (Dep. of Agro-Environmental Sciences, Fac. of Agriculture, Kyushu Univ., Fukuoka, JPN)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 22  Issue： 1  Page： 211-220  Publication year： Jan. 01, 2014 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： antitumor drug ,  *DNA topoisomerase I ,  DNA topoisomerase II ,  triterpene ,  chemical synthesis ,  docking ,  molecular recognition ,  isomerase ,  *enzyme inhibitor ,  alicyclic compound ,  lactone ,  phenolic compound ,  glycoside(except carbohydrate) ,  olefin compound ,  pyranoside ,  glucoside ,  phenol ether ,  polynuclear aromatic compound ,  pentacyclic triterpene ,  alicyclic alcohol ,  secondary alcohol ,  lactam ,  hydroxy compound
Semi thesaurus term： Topoisomerase I ,  Topoisomerase II ,  *topoisomerase II alpha ,  anticancer agent ,  *semisynthesis ,  molecular docking

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (10)： Etoposide ,  Oleanane ,  Oleanolic acid ,  Camptothecin ,  3β-(Benzylcarbamoyloxy)oleana-12-ene-28-oic acid ,  N-Benzyl-3β-(benzylcarbamoyloxy)oleana-12-ene-28-amide ,  3β-(Allylcarbamoyloxy)oleana-12-ene-28-oic acid ,  3β-(4-Biphenylylcarbamoyloxy)oleana-12-ene-28-oic acid ,  N-(1-Naphthyl)-3β-(1-naphthylcarbamoyloxy)oleana-12-ene-28-amide ,  N-(Phenylsulfonyl)-3β-(phenylsulfonylcarbamoyloxy)oleana-12-ene-28-amide

Terms in the title (7)： 抗癌剤 ,  オレアノール酸 ,  分子 ,  基盤 ,  トポイソメラーゼI ,  阻害剤 ,  設計