Art

J-GLOBAL ID：201402283190539990   Reference number：14A0951860

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

複製ストレスは老化した造血幹細胞の機能低下の強力な駆動因子である

Author (16)： FLACH Johanna (Univ. California San Francisco, California, USA) ,  BAKKER Sietske T. (Univ. California San Francisco, California, USA) ,  MOHRIN Mary (Univ. California San Francisco, California, USA) ,  PIETRAS Eric M. (Univ. California San Francisco, California, USA) ,  REYNAUD Damien (Univ. California San Francisco, California, USA) ,  PASSEGUE Emmanuelle (Univ. California San Francisco, California, USA) ,  FLACH Johanna (Comprehensive Cancer Center, Ulm, DEU) ,  CONROY Pauline C. (National Univ. Ireland Galway, Galway, IRL) ,  MORRISON Ciaran G. (National Univ. Ireland Galway, Galway, IRL) ,  ALVAREZ Silvia (Spanish National Cancer Res. Centre (CNIO), Madrid, ESP) ,  MENDEZ Juan (Spanish National Cancer Res. Centre (CNIO), Madrid, ESP) ,  DIOLAITI Morgan E. (Univ. California San Francisco, California, USA) ,  STOHR Bradley A. (Univ. California San Francisco, California, USA) ,  UGARTE Fernando (Univ. California Santa Cruz, California, USA) ,  FORSBERG E. Camilla (Univ. California Santa Cruz, California, USA) ,  LE BEAU Michelle M. (Univ. Chicago, Illinois, USA)
Material： Nature (London)  (Nature (Lond))
Volume： 512  Issue： 7513  Page： 198-202  Publication year： Aug. 14, 2014 
JST Material Number： D0193B  ISSN： 0028-0836  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *hematopoietic stem cell ,  *cell aging ,  DNA replication ,  rRNA gene ,  stress(physiology) ,  nucleolus ,  histone ,  genetic regulation ,  post-translational modification ,  DNA helicase
Semi thesaurus term： gamma H2AX ,  transcription control ,  *replicative stress ,  replication fork

JST classification (2)： Gene replication  (EC02030F) ,  Hematopoietic system  (EJ07020Y)

Terms in the title (5)： 複製ストレス ,  老化 ,  造血幹細胞 ,  機能低下 ,  因子