Art

J-GLOBAL ID：201402283365512870   Reference number：14A0231252

A Novel Inhibitor of I-KappaB Kinase Beta Ameliorates Experimental Arthritis through Downregulation of Proinflammatory Cytokines in Arthritic Joints

I-カッパBキナーゼβの新規阻害剤は関節炎罹患関節における炎症性サイトカインのダウンレギュレーションを介して実験的関節炎を改善する

Author (10)： TANAKA Shinji (R&D Div., Daiichi Sankyo Co., Ltd.) ,  TOKI Tadashi (R&D Div., Daiichi Sankyo Co., Ltd.) ,  YOKOYAMA Mika (R&D Div., Daiichi Sankyo Co., Ltd.) ,  SHIMIZU Hiroki (Organic Synthesis Dep., Daiichi Sankyo RD Novare Co., Ltd.) ,  YAMASAKI Tomonori (R&D Div., Daiichi Sankyo Co., Ltd.) ,  YONEDA Yoshiyuki (R&D Div., Daiichi Sankyo Co., Ltd.) ,  MURO Fumihito (R&D Div., Daiichi Sankyo Co., Ltd.) ,  YASUKOCHI Takanori (Organic Synthesis Dep., Daiichi Sankyo RD Novare Co., Ltd.) ,  IIMURA Shin (R&D Div., Daiichi Sankyo Co., Ltd.) ,  MORISHITA Kaoru (R&D Div., Daiichi Sankyo Co., Ltd.)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 37  Issue： 1  Page： 87-95 (J-STAGE)  Publication year： 2014 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： serine-threonine kinase ,...
Semi thesaurus term： IKK beta ,...

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JST classification (3)： Basic research of anti-inflammatory drugs  (GW15010T) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Basic medicine on musculoskeletal system  (GG01020B)

Substance index (1)： N-[[(2S,4R)-4-Fluoropyrrolidine-2-yl]methyl]-4-[6-(cyclobutylamino)imidazo[1,2-b]pyridazine-3-yl]-2-fluorobenzamide

Reference (49)：

• 1) Firestein GS. Evolving concepts of rheumatoid arthritis. Nature, 423, 356-361 (2003).
• 2) Brown KD, Claudio E, Siebenlist U. The roles of the classical and alternative nuclear factor-kappaB pathways: potential implications for autoimmunity and rheumatoid arthritis. Arthritis Res. Ther., 10, 212 (2008).
• 3) Choy EH, Panayi GS. Cytokine pathways and joint inflammation in rheumatoid arthritis. N. Engl. J. Med., 344, 907-916 (2001).
• 4) Eastgate JA, Wood NC, Di Giovine FS, Symons JA, Grinlinton FM, Duff GW. Correlation of plasma interleukin 1 levels with disease activity in rheumatoid arthritis. Lancet, 332, 706-709 (1988).
• 5) Houssiau FA, Devogelaer JP, Van Damme J, de Deuxchaisnes CN, Van Snick J. Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides. Arthritis Rheum., 31, 784-788 (1988).

Terms in the title (8)： I-カッパB ,  キナーゼ ,  阻害剤 ,  関節 ,  罹患 ,  炎症性サイトカイン ,  ダウンレギュレーション ,  実験的関節炎