Art

J-GLOBAL ID：201402283927342662   Reference number：14A0231228

Variability of Bioavailability and Intestinal Absorption Characteristics of Bisoprolol

ビソプロロールのバイオアベイラビリティの変動性と消化管吸収特性

Author (8)： ISHIDA Kazuya (Graduate School of Medicine and Pharmaceutical Sciences, Univ. of Toyama) ,  HORIE Asuka (Graduate School of Medicine and Pharmaceutical Sciences, Univ. of Toyama) ,  NISHIMURA Maki (Graduate School of Medicine and Pharmaceutical Sciences, Univ. of Toyama) ,  TAGUCHI Masato (Graduate School of Medicine and Pharmaceutical Sciences, Univ. of Toyama) ,  FUJII Nozomu (Graduate School of Medicine and Pharmaceutical Sciences, Univ. of Toyama) ,  NOZAWA Takashi (Graduate School of Medicine and Pharmaceutical Sciences, Univ. of Toyama) ,  INOUE Hiroshi (Graduate School of Medicine and Pharmaceutical Sciences, Univ. of Toyama) ,  HASHIMOTO Yukiya (Graduate School of Medicine and Pharmaceutical Sciences, Univ. of Toyama)
Material： Drug Metabolism and Pharmacokinetics  (Drug Metab Pharmacokinet)
Volume： 28  Issue： 6  Page： 491-496 (J-STAGE)  Publication year： 2013 
JST Material Number： X0758A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： intestinal epithelial cell

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JST classification (3)： Basic research of sympatholytics  (GW05024P) ,  Basic research of vasoactive drugs and hypotensive drugs  (GW07040J) ,  Clinical biopharmacy  (GY01022L)

Substance index (1)： Bisoprolol

Reference (19)：

• 1) Leopold, G.: Balanced pharmacokinetics and metabolism of bisoprolol. J. Cardiovasc. Pharmacol., 8 Suppl. 11: S16–S20 (1986).
• 2) Taguchi, M., Nozawa, T., Igawa, A., Inoue, H., Takesono, C., Tahara, K. and Hashimoto, Y.: Pharmacokinetic variability of routinely administered bisoprolol in middle-aged and elderly Japanese patients. Biol. Pharm. Bull., 28: 876–881 (2005).
• 3) Ishida, K., Okamoto, M., Ishibashi, M. and Hashimoto, Y.: Population pharmacokinetics of mizoribine in adult recipients of renal transplantation. Clin. Exp. Nephrol., 15: 900–906 (2011).
• 4) Ishida, K., Motoyama, O., Shishido, S., Tsuzuki, K. and Hashimoto, Y.: Population pharmacokinetics of mizoribine in pediatric recipients of renal transplantation. Clin. Exp. Nephrol., 16: 799–804 (2012).
• 5) Horikiri, Y., Suzuki, T. and Mizobe, M.: Pharmacokinetics and metabolism of bisoprolol enantiomers in humans. J. Pharm. Sci., 87: 289–294 (1998).

Terms in the title (4)： ビソプロロール ,  バイオアベイラビリティ ,  変動性 ,  消化管吸収