Art

J-GLOBAL ID：201402285919767010   Reference number：14A1403069

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

がんのチェックポイント阻害免疫療法は腫瘍特異的な変異抗原を標的にする

Author (29)： GUBIN Matthew M. (Washington Univ. School of Medicine, Missouri, USA) ,  WARD Jeffrey P. (Washington Univ. School of Medicine, Missouri, USA) ,  NOGUCHI Takuro (Washington Univ. School of Medicine, Missouri, USA) ,  IVANOVA Yulia (Washington Univ. School of Medicine, Missouri, USA) ,  ARTHUR Cora D. (Washington Univ. School of Medicine, Missouri, USA) ,  VESELY Matthew D. (Washington Univ. School of Medicine, Missouri, USA) ,  LAM Samuel S. K. (Washington Univ. School of Medicine, Missouri, USA) ,  PEARCE Erika L. (Washington Univ. School of Medicine, Missouri, USA) ,  ARTYOMOV Maxim N. (Washington Univ. School of Medicine, Missouri, USA) ,  SCHREIBER Robert D. (Washington Univ. School of Medicine, Missouri, USA) ,  ZHANG Xiuli (Washington Univ. School of Medicine, Missouri, USA) ,  GILLANDERS William E. (Washington Univ. School of Medicine, Missouri, USA) ,  SCHUSTER Heiko (German Cancer Consortium (DKTK), Tuebingen, DEU) ,  RAMMENSEE Hans-Georg (German Cancer Consortium (DKTK), Tuebingen, DEU) ,  CARON Etienne (ETH Zurich, Zurich, CHE) ,  AEBERSOLD Ruedi (ETH Zurich, Zurich, CHE) ,  HUNDAL Jasreet (Washington Univ. School of Medicine, Missouri, USA) ,  MARDIS Elaine R. (Washington Univ. School of Medicine, Missouri, USA) ,  KREBBER Willem-Jan (ISA Therapeutics B.V., Leiden, NLD) ,  MULDER Gwenn E. (ISA Therapeutics B.V., Leiden, NLD) ,  MELIEF Cornelis J. M. (ISA Therapeutics B.V., Leiden, NLD) ,  TOEBES Mireille (Netherlands Cancer Inst., Amsterdam, NLD) ,  SCHUMACHER Ton N. (Netherlands Cancer Inst., Amsterdam, NLD) ,  KORMAN Alan J. (Bristol-Myers Squibb, California, USA) ,  ALLISON James P. (Univ. Texas MD Anderson Cancer Center, Texas, USA) ,  FREEMAN Gordon J. (Harvard Medical School, Massachusetts, USA) ,  SHARPE Arlene H. (Harvard Medical School, Massachusetts, USA) ,  AEBERSOLD Ruedi (Univ. Zurich, Zurich, Zurich, CHE) ,  MELIEF Cornelis J. M. (Leiden Univ. Medical Center, Leiden, NLD)
Material： Nature (London)  (Nature (Lond))
Volume： 515  Issue： 7528  Page： 577-581  Publication year： Nov. 27, 2014 
JST Material Number： D0193B  ISSN： 0028-0836  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： carcinogenesis ,  *tumor antigen ,  CD antigen ,  membrane protein ,  transmembrane protein ,  information science ,  biology ,  genetics ,  epitope ,  *tumor vaccine ,  sarcoma ,  immunotherapy ,  T cell
Semi thesaurus term： T lymphocyte ,  CTLA4 ,  PD-1 ,  Genomics ,  bioinformatics ,  *peptide vaccine

JST classification (2)： Tumor immunity  (ED03040A) ,  Immunotherapy for tumors  (GE03035B)

Terms in the title (8)： がん ,  チェックポイント ,  阻害 ,  免疫療法 ,  腫瘍 ,  変異 ,  抗原 ,  標的