Art

J-GLOBAL ID：201402286205973330   Reference number：14A0716369

Novel synthetic route for antimalarial benzo[a]phenoxazine derivative SSJ-183 and two active metabolites

抗マラリア活性を有するベンゾ[a]フェノキサジン誘導体SSJ-183および2種の活性代謝物の新規合成経路

Author (16)： MIZUKAWA Yuki (Drug Discovery Sci. Res. Center, Hoshi Univ., 2-4-41 Ebara, Shinagawa, Tokyo 142-8501, JPN) ,  MIZUKAWA Yuki (Synstar Japan Co., Ltd, Orbic Bldg 3F, 2-9-46 Sakaecho, Odawara 250-0011, JPN) ,  GE Jian-feng (Drug Discovery Sci. Res. Center, Hoshi Univ., 2-4-41 Ebara, Shinagawa, Tokyo 142-8501, JPN) ,  GE Jian-feng (Coll. of Chemistry, Chemical Engineering and Materials Sci., Soochow Univ., Suzhou 215006, CHN) ,  BAKAR MD Abu (Drug Discovery Sci. Res. Center, Hoshi Univ., 2-4-41 Ebara, Shinagawa, Tokyo 142-8501, JPN) ,  BAKAR MD Abu (Center for Advanced Res. in Sciences, Univ. of Dhaka, Bangladesh) ,  ITOH Isamu (Drug Discovery Sci. Res. Center, Hoshi Univ., 2-4-41 Ebara, Shinagawa, Tokyo 142-8501, JPN) ,  ITOH Isamu (Synstar Japan Co., Ltd, Orbic Bldg 3F, 2-9-46 Sakaecho, Odawara 250-0011, JPN) ,  SCHEURER Christian (Swiss Tropical and Public Health Inst., Socinstrasse 57, 4002 Basel, CHE) ,  SCHEURER Christian (Univ. of Basel, CH-4003 Basel, CHE) ,  WITTLIN Sergio (Swiss Tropical and Public Health Inst., Socinstrasse 57, 4002 Basel, CHE) ,  WITTLIN Sergio (Univ. of Basel, CH-4003 Basel, CHE) ,  BRUN Reto (Swiss Tropical and Public Health Inst., Socinstrasse 57, 4002 Basel, CHE) ,  BRUN Reto (Univ. of Basel, CH-4003 Basel, CHE) ,  MATSUOKA Hiroyuki (School of Medicine, Dep. of Infection and Immunity, Div. of Medical Zoology, Jichi Medical Univ., 3311-1 Yakushiji ...) ,  IHARA Masataka (Drug Discovery Sci. Res. Center, Hoshi Univ., 2-4-41 Ebara, Shinagawa, Tokyo 142-8501, JPN)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 22  Issue： 14  Page： 3749-3752  Publication year： Jul. 15, 2014 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *antimalarial drug ,  *one-pot synthesis ,  Drug Resistance ,  Plasmodium falciparum ,  drug metabolism ,  microorganism ,  protozoa ,  Sporozoa
Semi thesaurus term： Drug Resistance

JST classification (2)： Basic research of antiprotozoan drugs and anthelmintics  (GW17080G) ,  Synthesis of drugs  (GV01030F)

Substance index (1)： SSJ-183

Terms in the title (5)： 抗マラリア活性 ,  フェノキサジン誘導体 ,  SSJ-183 ,  活性代謝物 ,  合成経路