Art

J-GLOBAL ID：201402289481467618   Reference number：14A0571664

Variability of Bioavailability and Intestinal Absorption Mechanisms of Metoprolol

メトプロロールのバイオアベイラビリティ変動性と腸管吸収メカニズム

Author (7)： FUKAO Miki (Graduate School of Medicine and Pharmaceutical Sciences, Univ. of Toyama) ,  ISHIDA Kazuya (Graduate School of Medicine and Pharmaceutical Sciences, Univ. of Toyama) ,  HORIE Asuka (Graduate School of Medicine and Pharmaceutical Sciences, Univ. of Toyama) ,  TAGUCHI Masato (Graduate School of Medicine and Pharmaceutical Sciences, Univ. of Toyama) ,  NOZAWA Takashi (Graduate School of Medicine and Pharmaceutical Sciences, Univ. of Toyama) ,  INOUE Hiroshi (Graduate School of Medicine and Pharmaceutical Sciences, Univ. of Toyama) ,  HASHIMOTO Yukiya (Graduate School of Medicine and Pharmaceutical Sciences, Univ. of Toyama)
Material： Drug Metabolism and Pharmacokinetics  (Drug Metab Pharmacokinet)
Volume： 29  Issue： 2  Page： 162-167 (J-STAGE)  Publication year： 2014 
JST Material Number： X0758A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *gastrointestinal absorption ,...
Semi thesaurus term： Cell Line

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JST classification (3)： Basic biopharmacy  (GY01021U) ,  Basic research of sympatholytics  (GW05024P) ,  Interactions of drugs  (GV01070X)

Substance index (5)： Quinidine ,  Diphenhydramine ,  Bisoprolol ,  Procainamide ,  Metoprolol

Reference (22)：

• 1) Huang, J. D., Chuang, S. K., Cheng, C. L. and Lai, M. L.: Pharmacokinetics of metoprolol enantiomers in Chinese subjects of major CYP2D6 genotypes. Clin. Pharmacol. Ther., 65: 402–407 (1999).
• 2) Taguchi, M., Nozawa, T., Mizumaki, K., Inoue, H., Tahara, K., Takesono, C. and Hashimoto, Y.: Nonlinear mixed effects model analysis of the pharmacokinetics of metoprolol in routinely treated Japanese patients. Biol. Pharm. Bull., 27: 1642–1648 (2004).
• 3) Ishida, K., Horie, A., Nishimura, M., Taguchi, M., Fujii, N., Nozawa, T., Inoue, H. and Hashimoto, Y.: Variability of bioavailability and intestinal absorption characteristics of bisoprolol. Drug Metab. Pharmacokinet., 28: 491–496 (2013).
• 4) Leopold, G.: Balanced pharmacokinetics and metabolism of bisoprolol. J. Cardiovasc. Pharmacol., 8 Suppl. 11: S16–S20 (1986).
• 5) Horikiri, Y., Suzuki, T. and Mizobe, M.: Pharmacokinetics and metabolism of bisoprolol enantiomers in humans. J. Pharm. Sci., 87: 289–294 (1998).

Terms in the title (5)： メトプロロール ,  バイオアベイラビリティ ,  変動性 ,  腸管吸収 ,  メカニズム