Art

J-GLOBAL ID：201402289624332964   Reference number：14A0132013

A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations

喘息:ゲノムワイド関連研究からCDHR3が重度の増悪を伴う幼児期喘息の感受性座位であることが明らかになる

Author (40)： BONNELYKKE Klaus (Copenhagen Univ. Hospital, Gentofte, DNK) ,  KREINER-MOLLER Eskil (Copenhagen Univ. Hospital, Gentofte, DNK) ,  HUSBY Anders (Copenhagen Univ. Hospital, Gentofte, DNK) ,  SEVELSTED Astrid (Copenhagen Univ. Hospital, Gentofte, DNK) ,  MORTENSEN Li Juel (Copenhagen Univ. Hospital, Gentofte, DNK) ,  FLAATEN Richard (Copenhagen Univ. Hospital, Gentofte, DNK) ,  MOLGAARD Anne (Copenhagen Univ. Hospital, Gentofte, DNK) ,  BISGAARD Hans (Copenhagen Univ. Hospital, Gentofte, DNK) ,  SLEIMAN Patrick (Children’s Hospital of Philadelphia (CHOP), Pennsylvania, USA) ,  MARCH Michael E (Children’s Hospital of Philadelphia (CHOP), Pennsylvania, USA) ,  HAKONARSON Hakon (Children’s Hospital of Philadelphia (CHOP), Pennsylvania, USA) ,  NIELSEN Kasper (Technical Univ. Denmark, Lyngby, DNK) ,  YADAV Rachita (Technical Univ. Denmark, Lyngby, DNK) ,  GUPTA Ramneek (Technical Univ. Denmark, Lyngby, DNK) ,  MERCADER Josep M (Barcelona Supercomputing Center, Barcelona, ESP) ,  BONAS-GUARCH Silvia (Barcelona Supercomputing Center, Barcelona, ESP) ,  TORRENTS David (Barcelona Supercomputing Center, Barcelona, ESP) ,  BELGRAVE Danielle (Univ. Manchester and Univ. Hospital of South Manchester, Manchester, GBR) ,  SIMPSON Angela (Univ. Manchester and Univ. Hospital of South Manchester, Manchester, GBR) ,  CUSTOVIC Adnan (Univ. Manchester and Univ. Hospital of South Manchester, Manchester, GBR) ,  DEN DEKKER Herman T (Erasmus Medical Center, Rotterdam, NLD) ,  JADDOE Vincent W V (Erasmus Medical Center, Rotterdam, NLD) ,  DUIJTS Liesbeth (Erasmus Medical Center, Rotterdam, NLD) ,  HUSBY Anders (Univ. Southampton, Southampton, GBR) ,  SMART David E (Univ. Southampton, Southampton, GBR) ,  DAVIES Donna E (Univ. Southampton, Southampton, GBR) ,  FAURA-TELLEZ Grissel (Univ. Southampton, Southampton, GBR) ,  LACKIE Peter M (Univ. Southampton, Southampton, GBR) ,  HOLLOWAY John W (Univ. Southampton, Southampton, GBR) ,  FAURA-TELLEZ Grissel (Univ. Groningen, Groningen, NLD) ,  PATERNOSTER Lavinia (Univ. Bristol, Bristol, GBR) ,  THOMSEN Philip F (Univ. Copenhagen, Copenhagen, DNK) ,  RASMUSSEN Morten A (Univ. Copenhagen, Copenhagen, DNK) ,  HOLST Claus (Copenhagen Univ. Hospital, Copenhagen, DNK) ,  NOHR Ellen A (Univ. Southern Denmark, Aarhus, DNK) ,  NOHR Ellen A (Aarhus Univ., Aarhus, DNK) ,  BLICHER Thomas (Univ. Copenhagen, Copenhagen, DNK) ,  TORRENTS David (Institutetucio Catalana de Recerca i Estudis Avancats (ICREA), Barcelona, ESP) ,  HOLLEGAARD Mads V (Statens Serum Inst. (SSI), Copenhagen, DNK) ,  HOUGAARD David M (Statens Serum Inst. (SSI), Copenhagen, DNK)
Material： Nature Genetics  (Nat Genet)
Volume： 46  Issue： 1  Page： 51-55  Publication year： Jan. 2014 
JST Material Number： W0430A  ISSN： 1061-4036  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： genetic technique ,  *gene ,  *asthma ,  Kingdom of Denmark ,  case control study ,  gene locus ,  risk factor ,  human ,  neonate ,  population (statistics) ,  deterioration (worse) ,  Phenotype ,  Genome-Wide Association Study
Semi thesaurus term： *CDHR3遺伝子 ,  cohort ,  deterioration

JST classification (1)： Genetic variation  (EC01030Y)

Terms in the title (7)： 喘息 ,  ゲノム ,  研究 ,  増悪 ,  幼児期 ,  感受性 ,  座位