Art

J-GLOBAL ID：201402290125554148   Reference number：14A0165402

Shuttling Protein Nucleolin Is a Microglia Receptor for Amyloid Beta Peptide 1-42

シャトルタンパク質ヌクレオリンはアミロイドβペプチド1-42に対するミクログリアの受容体である

Author (6)： OZAWA Daisuke (School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences) ,  NAKAMURA Takashi (School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences) ,  KOIKE Masanori (School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences) ,  HIRANO Kazuya (School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences) ,  MIKI Yuichi (School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences) ,  BEPPU Masatoshi (School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 36  Issue： 10  Page： 1587-1593 (J-STAGE)  Publication year： 2013 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Alzheimer Disease ,...
Semi thesaurus term： Amyloid beta-Peptides ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=14A0165402&from=J-GLOBAL&jstjournalNo=S0989A") }}

JST classification (3)： Basic neurology  (GN01020W) ,  Cell physiology in general  (EF02010S) ,  Metabolism in general  (EB03050F)

Reference (40)：

• 1) Duyckaerts C, Delatour B, Potier MC. Classification and basic pathology of Alzheimer disease. Acta Neuropathol., 118, 5-36 (2009).
• 2) Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH, Multhaup G, Beyreuther K, Muller-Hill B. The precursor of Alzheimer’s disease amyloid A4 protein resembles a cell-surface receptor. Nature, 325, 733-736 (1987).
• 3) Miller DL, Papayannopoulos IA, Styles J, Bobin SA, Lin YY, Biemann K, Iqbal K. Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer’s disease. Arch. Biochem. Biophys., 301, 41-52 (1993).
• 4) Roher AE, Lowenson JD, Clarke S, Wolkow C, Wang R, Cotter RJ, Reardon IM, Zurcher-Neely HA, Heinrikson RL, Ball MJ, Greenberg BD. Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer’s disease. J. Biol. Chem., 268, 3072-3083 (1993).
• 5) Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K. Amyloid plaque core protein in Alzheimer’s disease and Down syndrome. Proc. Natl. Acad. Sci. U.S.A., 82, 4245-4249 (1985).

Terms in the title (6)： シャトル ,  タンパク質 ,  ヌクレオリン ,  アミロイドβペプチド ,  ミクログリア ,  受容体