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J-GLOBAL ID：201402290772899750   Reference number：14A0516725

Covalent Chromatography for Chymotrypsin-like Proteases Using a Diphenyl 1-Amino-2-phenylethylphosphonate Derivative

ジフェニル1-アミノ-2-フェニルエチルホスホン酸誘導体を用いたキモトリプシン様プロテイナーゼのコバレントクロマトグラフィー

Author (9)： ONO Shin (Univ. Toyama, Toyama, JPN) ,  MURAI Junya (Univ. Toyama, Toyama, JPN) ,  FURUTA Seigo (Univ. Toyama, Toyama, JPN) ,  DOIKE Kazuya (Univ. Toyama, Toyama, JPN) ,  MANZAKI Fumie (Univ. Toyama, Toyama, JPN) ,  YOSHIMURA Toshiaki (Univ. Toyama, Toyama, JPN) ,  KURODA Hirofumi (Toyama National Coll. Technol., Toyama, JPN) ,  UMEZAKI Masahito (Univ. Toyama, Toyama, JPN) ,  OYAMA Hiroshi (Setsunan Univ., Osaka, JPN)
Material： 生物高分子  (Journal of Biological Macromolecules)
Volume： 13  Issue： 3  Page： 78-85  Publication year： Dec. 31, 2013 
JST Material Number： L4559A  ISSN： 1347-2194  CODEN： JBM0A6  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： chymotrypsin ,...
Semi thesaurus term： *キモトリプシン様プロテイナーゼ ,...

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JST classification (2)： Biochemical analytical methods  (EA03030G) ,  Proteins and peptides in general  (EB03010N)

Substance index (2)： 2-PAM ,  α-Aminophenethylphosphonic acid diphenyl ester

Reference (16)：

• J. Oleksyszyn, J.C. Powers, Amino acid and peptide phosphonate derivatives as specific inhibitors of serine peptidases, Methods Enzymol. 244 (1994) 423-441.
• S.L. Woodard, D.S. Jackson, A.S. Abuelyaman, J.C. Powers, U. Winker, D. Hudig, Chymase-directed serine protease inhibitor that reacts with a single 30-kDa granzyme and blocks NK-mediated cytotoxiciy, J. Immunol. 153 (1994) 5016-5025.
• A.S. Abuelyaman, D. Hudig, S.L. Woodard, J.C. Powers, Fluorescent derivatives of diphenyl [1-(N-peptidylamino)alkyl]phosphonate esters: Synthesis and use in the inhibition and cellular localization of serine proteases, Bioconjugate Chem. 5 (1994) 400-405.
• R.E. Morty, L.Troeberg, J.C. Powers, S. Ono, J.D. Lonsdale-Eccles, T.H.T. Coetzer, Characterization of the antitrypanosomal activity of peptidyl α-aminoalkyl phosphonate diphenyl esters, Biochem. Pharmacol. 60 (2000) 1497-1504.
• R.K. Jakobsen, S. Ono, J.C. Powers, R. DeLotto, Fluorescently labeled inhibitors detect localized serine protease activities in Drosophila melanogaster pole cells, embryos, and ovarian egg chanmbers, Histochem Cell Biol. 123 (2005) 51-60.

Terms in the title (6)： ジフェニル ,  フェニル ,  エチルホスホン酸 ,  誘導体 ,  キモトリプシン ,  プロテイナーゼ