Art

J-GLOBAL ID：201402291434257618   Reference number：14A0666791

SYNTHETIC ACCESS TO POLY-SUBSTITUTED 11H-PYRIDO[3,2-a]CARBAZOLES, A DNA-INTERCALATING ELLIPTICINE RELATED STRUCTURE, AND THEIR ANTIPROLIFERATIVE ACTIVITY

多置換11H-ピリド[3,2-a]カルバゾール類への合成アクセス,DNAインターカレーティングエリプチシン関連組織およびそれらの抗増殖作用

Author (14)： WU Ming-Yu (Okayama Univ., Okayama, JPN) ,  WU Ming-Yu (Sichuan Univ., Chengdu, CHN) ,  SHABAN Elkhabiry (Okayama Univ., Okayama, JPN) ,  SWITALSKA Marta (Inst. of Immunology and Experimental Therapy, Polish Acad. of Sci., Wroclaw, POL) ,  WANG Ning (Okayama Univ., Okayama, JPN) ,  SHIMODA Miho (Okayama Univ., Okayama, JPN) ,  MIZUTANI Yusuke (Okayama Univ. Sci., Okayama, JPN) ,  YOSHIDA Megumi (Okayama Univ., Okayama, JPN) ,  MEI Zhen-Wu (Okayama Univ., Okayama, JPN) ,  KAWAFUCHI Hiroyuki (Toyama National Coll. of Technol., Toyama, JPN) ,  NOKAMI Junzo (Okayama Univ. Sci., Okayama, JPN) ,  WIETRZYK Joanna (Inst. of Immunology and Experimental Therapy, Polish Acad. of Sci., Wroclaw, POL) ,  YU Xiao-Qi (Sichuan Univ., Chengdu, CHN) ,  INOKUCHI Tsutomu (Okayama Univ., Okayama, JPN)
Material： Heterocycles  (International Journal for Reviews and Communications in Heterocyclic Chemistry)
Volume： 89  Issue： 6  Page： 1427-1440  Publication year： Jun. 01, 2014 
JST Material Number： S0966A  ISSN： 0385-5414  CODEN： HTCYAM  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： action and effect ,  *nitrogen heterocyclic compound ,  DNA ,  enamine ,  enone ,  chemical synthesis ,  molecular structure ,  Fischer indole synthesis ,  *cyclization reaction ,  effect ,  indole alkaloid ,  polynuclear aromatic compound ,  oxidation
Semi thesaurus term： enaminone ,  carbazole derivative ,  Pyridines ,  anti-proliferative activity ,  Bioeffect

JST classification (2)： Nitrogen heterocycles in general  (CF07040G) ,  Cyclization reaction,ring-opening reaction  (CF02050I)

Substance index (13)： Ellipticine ,  5,6-Dihydro-11H-pyrido[3,2-a]carbazole-2-carboxylic acid methyl ester ,  8-Bromo-5,6-dihydro-11H-pyrido[3,2-a]carbazole-2-carboxylic acid methyl ester ,  6-Methyl-5,6-dihydro-11H-pyrido[3,2-a]carbazole-2-carboxylic acid methyl ester ,  6-Phenyl-5,6-dihydro-11H-pyrido[3,2-a]carbazole-2-carboxylic acid methyl ester ,  11H-Pyrido[3,2-a]carbazole-2-carboxylic acid methyl ester ,  8-Bromo-11H-pyrido[3,2-a]carbazole-2-carboxylic acid methyl ester ,  6-Methyl-11H-pyrido[3,2-a]carbazole-2-carboxylic acid methyl ester ,  6-Phenyl-11H-pyrido[3,2-a]carbazole-2-carboxylic acid methyl ester ,  6,6-Dimethyl-5,6-dihydro-11H-pyrido[3,2-a]carbazole-2-carboxylic acid methyl ester ,  5,6-Dimethyl-11H-pyrido[3,2-a]carbazole-2-carboxylic acid methyl ester ,  5-Oxo-6,6-dimethyl-5,6-dihydro-11H-pyrido[3,2-a]carbazole-2-carboxylic acid methyl ester ,  4-Methyl-(11H-pyrido[3,2-a]carbazole-4-ium)-2-carboxylic acid methyl ester

Reference (34)：

• N. J. Rahier, C. J. Thomas, and S. M. Hecht, in Anticancer Agents from Natural Products, 2nd ed. by G. M. Cragg, D. G. I. Kingston, and D. J. Newman, CRC press, Boca Raton, FL, 2012, pp. 5-25.
• Review: C. M. Miller and F. O. McCarthy, RSC Advances, 2012, 2, 8883.
• S. Goodwin,A. F. Smith,and E. C. Horning, J. Am. Chem. Soc., 1959,81, 1903.
• a) M. Stiborová, C. A. Bieler, M. Wiessler, and E. Frei, Biochem. Pharmacol., 2001, 62, 1675; b) M. Stiborova, J. Poljakova, E. Martinkova, L. Booek-Dohalska, T. Eckschlager, R. Kizek, and E. Frei, Interdiscip. Toxicol., 201 1, 4, 98; c) A. M. Pohlit, L. F. Rocha e Silva, M. C. Henrique, A. Montoia, R. C. N. Amorim, S. M. Nunomura, and V. F. Andrade-Neto, Phytomedicine, 2012, 19, 1049.
• S. C. Jain,K. K. Bhandary,and H. M. Sobell, J. Mol. Bio., 1979, 135, 813.

Terms in the title (6)： 置換 ,  カルバゾール類 ,  アクセス ,  DNA ,  組織 ,  抗増殖作用