Art

J-GLOBAL ID：201402291954832330   Reference number：13A1956692

Treatment with 17-allylamino-17-demethoxygeldanamycin ameliorated symptoms of Bartter syndrome type IV caused by mutated Bsnd in mice

17-アリルアミノ-17-デメトキシゲルダナマイシンによる処理はマウスにおいて突然変異により引き起こされたBartter症候群タイプIVの症状を改善した

Author (9)： NOMURA Naohiro (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  YUI Naofumi (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  CHIGA Motoko (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  SOHARA Eisei (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  RAI Tatemitu (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  SAKAKI Sei (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  UCHIDA Shinich (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  KAMIYA Kazusaku (Juntendo Univ. Fac. of Medicine, Tokyo, JPN) ,  IKEDA Katsuhisa (Juntendo Univ. Fac. of Medicine, Tokyo, JPN)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 441  Issue： 3  Page： 544-549  Publication year： 2013 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *antineoplastic antibiotics ,  mouse(animal) ,  *mutation ,  *Bartter syndrome ,  symptom ,  hypokalemia ,  salinity ,  body fluid ,  metabolic disease ,  alkalosis ,  sensorineural hearing loss ,  potassium channel ,  cell membrane ,  transportation ,  kidney ,  internal ear ,  mutant ,  endoplasmic reticulum ,  chaperone protein ,  heat shock protein ,  antitumor drug ,  molecular targeting drug ,  dog ,  laboratory animal ,  *antibiotics ,  quinone ,  alicyclic compound ,  macrocyclic compound ,  lactam ,  diene ,  carbamate ,  enol ether ,  diol
Semi thesaurus term： Body fluid volume depletion ,  Alkalosis metabolic ,  salt transport ,  HSP90 Heat-Shock Proteins ,  HSP90 inhibitor ,  knock-in mouse

JST classification (6)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Genetic variation  (EC01030Y) ,  Endocrine diseases  (GL03000I) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Diseases of ear,nose,pharynx and larynx  (GQ03000X) ,  Transport of cell membrane  (EF04020R)

Substance index (1)： Geldanamycin

Terms in the title (5)： マウス ,  突然変異 ,  Bartter症候群 ,  タイプ ,  症状