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J-GLOBAL ID:201402294570602018   Reference number:14A1397037

Dioscorea japonica extract down-regulates prostaglandin E2 synthetic pathway and induces apoptosis in lung cancer cells

ヤマノイモ抽出液は肺癌細胞においてプロスタグランジンE2合成経路をダウンレギュレートし,アポトーシスを誘導する
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Volume: 55  Issue:Page: 162-167 (J-STAGE)  Publication year: 2014 
JST Material Number: X0851A  ISSN: 0912-0009  Document type: Article
Article type: 原著論文  Country of issue: Japan (JPN)  Language: ENGLISH (EN)
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Basic research of pharmacology of crude drugs 
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Reference (34):
  • 1 Shimizu T, Wolfe LS. Arachidonic acid cascade and signal transduction. J Neurochem 1990; 55: 1-15.
  • 2 Hida T, Yatabe Y, Achiwa H, et al. Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas. Cancer Res 1998; 58: 3761-3764.
  • 3 Smith WL, Marnett LJ. Prostaglandin endoperoxide synthase: structure and catalysis. Biochim Biophys Acta 1991; 1083: 1-17.
  • 4 Smith WL, Garavito RM, DeWitt DL. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J Biol Chem 1996; 271: 33157-33160.
  • 5 Jakobsson PJ, Thorén S, Morgenstern R, Samuelsson B. Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc Natl Acad Sci U S A 1999; 96: 7220-7225.
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