Art

J-GLOBAL ID：201402295033832771   Reference number：14A1021035

Development of novel non-secosteroidal VDR ligands based on spherical hydrophobic pharmacophores

球状疎水性ファーマコフォアを有する非セコステロイド型VDRリガンドの創製研究

Author (5)： FUJII SHIN'YA (東京医歯大 生体材料工研) ,  FUJII SHIN'YA (東大 分子細胞生物学研) ,  TANATANI AYA (お茶の水女大 大学院人間文化創成科学研究科) ,  HIRANO TOMOYA (東京医歯大 生体材料工研) ,  KAGECHIKA HIROYUKI (東京医歯大 生体材料工研)
Material： ビタミン  (Vitamins)
Volume： 88  Issue： 8  Page： 389-395  Publication year： Aug. 25, 2014 
JST Material Number： F0426A  ISSN： 0006-386X  CODEN： BTMNA7  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *vitamin D receptor ,...
Semi thesaurus term： X-ray crystallography ,...

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JST classification (2)： Receptors on cell membrane  (EF04030C) ,  Vitamin D  (EB07050H)

Substance index (1)： Bicyclo(2.2.2)octane

Reference (23)：

• Feldman D, Pike JW, Glorieux FH eds. (2005) Vitamin D, 2nd ed. Elsevier Academic Press, New York, US.
• Kubodera N (2005) Development of OCT and ED-71. In 'Vitamin D, 2nd ed.' Ed by Feldman D, Pike JW, Glorieux FH. pp 1525-1541, Elsevier Academic Press, New York, US.
• Boehm MF, Fitzgerald P, Zou A, Elgort MG, Bischoff ED, Mere L, Mais DE, Bissonnette RP, Heyman RA, Nadzan AM, Reichman M, Allegretto EA (1999) Novel nonsecosteroidal vitamin D mimics exert VDR-modulating activities with less calcium mobilization than 1,25-dihydroxyvitamin D₃. Chem. Biol 6, 265-275
• Ma Y, Khalifa B, Yee YK, Lu J, Memezawa, A, Savkur RS, Yamamoto Y, Chintalacharuvu SR, Yamaoka K, Stayrook KR, Bramlett KS, Zeng QQ, Chandrasekhar S, Yu X-P, Linebarger JH, Iturria SJ, Burris TP, Kato S, Chin WW, Nagpal S (2006). Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin D receptor modulators. J. Clin. Invest 116, 892-904
• Hosoda S, Tanatani A, Wakabayashi K, Makishima M, Imai K, Miyachi H, Nagasawa K, Hashimoto Y (2006) Ligands with a 3,3-di- phenylpentane skeleton for nuclear vitamin D and androgen receptors: Dual activities and metabolic activation. Bioorg. Med. Chem 14, 5489-5502

Terms in the title (7)： 球状 ,  疎水性 ,  ファーマコフォア ,  セコステロイド ,  リガンド ,  創製 ,  研究