Art

J-GLOBAL ID：201402298544384490   Reference number：14A0718730

Induction of activation-induced cytidine deaminase by a not-directly mutagenic carcinogen: a novel potential molecular mechanism

非直接的変異原性発癌物質による活性化誘導シチジンデアミナーゼの誘導 新規の潜在的分子機構

Author (4)： TATEMICHI Masayuki (Showa Univ., Tokyo, JPN) ,  TATEMICHI Masayuki (Tokai Univ., Kanagawa, JPN) ,  HATA Harumi (Showa Univ., Tokyo, JPN) ,  NAKADATE Toshio (Showa Univ., Tokyo, JPN)
Material： Environmental Health and Preventive Medicine (Web)
Volume： 19  Issue： 3  Page： 238-244  Publication year： May. 2014 
JST Material Number： U1065A  ISSN： 1347-4715  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *carcinogen ,...
Semi thesaurus term： activation-induced cytidine deaminase ,...

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JST classification (1)： Carcinogenic mechanisms and factors  (GE02020C)

Reference (22)：

• Hernandez LG, van Steeg H, Luijten M, van Benthem J. Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach. Mutat Res. 2009;682:94–109.
• Melnick RL, Kohn MC, Portier CJ. Implications for risk assessment of suggested nongenotoxic mechanisms of chemical carcinogenesis. Environ Health Perspect. 1996;104:123–34.
• Williams GM. Mechanisms of chemical carcinogenesis and application to human cancer risk assessment. Toxicology. 2001;166:3–10.
• Okazaki IM, Kinoshita K, Muramatsu M, Yoshikawa K, Honjo T. The AID enzyme induces class switch recombination in fibroblasts. Nature. 2002;416:340–5.
• Matsumoto Y, Marusawa H, Kinoshita K, Endo Y, Kou T, Morisawa T, et al. Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Nat Med. 2007;13:470–6.

Terms in the title (5)： 変異原性 ,  発癌物質 ,  活性化誘導シチジンデアミナーゼ ,  誘導 ,  分子機構