Art
J-GLOBAL ID：201402299530430836   Reference number：14A0466928

Structure-activity relationship of celecoxib and rofecoxib for the membrane permeabilizing activity

膜透過性活性に対するセレコキシブ及びロフェコキシブの構造活性相関
Author (9)：
YAMAKAWA Naoki

About YAMAKAWA Naoki

(Fac. of Pharmacy, Keio Univ., Tokyo 105-8512, JPN)

About Fac. of Pharmacy, Keio Univ., Tokyo 105-8512, JPN

, 
YAMAKAWA Naoki

About YAMAKAWA Naoki

(Shujitsu Univ. School of Pharmacy, Okayama 703-8516, JPN)

About Shujitsu Univ. School of Pharmacy, Okayama 703-8516, JPN

, 
SUZUKI Koichiro

About SUZUKI Koichiro

(Fac. of Pharmacy, Keio Univ., Tokyo 105-8512, JPN)

About Fac. of Pharmacy, Keio Univ., Tokyo 105-8512, JPN

, 
YAMASHITA Yasunobu

About YAMASHITA Yasunobu

(Fac. of Pharmacy, Keio Univ., Tokyo 105-8512, JPN)

About Fac. of Pharmacy, Keio Univ., Tokyo 105-8512, JPN

, 
KATSU Takashi

About KATSU Takashi

(Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama Univ., Okayama 700-8530, JPN)

About Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama Univ., Okayama 700-8530, JPN

, 
HANAYA Kengo

About HANAYA Kengo

(Fac. of Pharmacy, Keio Univ., Tokyo 105-8512, JPN)

About Fac. of Pharmacy, Keio Univ., Tokyo 105-8512, JPN

, 
SHOJI Mitsuru

About SHOJI Mitsuru

(Fac. of Pharmacy, Keio Univ., Tokyo 105-8512, JPN)

About Fac. of Pharmacy, Keio Univ., Tokyo 105-8512, JPN

, 
SUGAI Takeshi

About SUGAI Takeshi

(Fac. of Pharmacy, Keio Univ., Tokyo 105-8512, JPN)

About Fac. of Pharmacy, Keio Univ., Tokyo 105-8512, JPN

, 
MIZUSHIMA Tohru

About MIZUSHIMA Tohru

(Fac. of Pharmacy, Keio Univ., Tokyo 105-8512, JPN)

About Fac. of Pharmacy, Keio Univ., Tokyo 105-8512, JPN


Material：
Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)

About Bioorganic & Medicinal Chemistry


Volume： 22  Issue： 8  Page： 2529-2534  Publication year： Apr. 15, 2014 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)
Thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
*property

About property

, 
*Structure-Activity Relationship

About Structure-Activity Relationship

, 
cyclooxygenase

About cyclooxygenase

, 
enzyme inhibition

About enzyme inhibition

, 
synthesis

About synthesis

, 
displacement (replacement)

About displacement (replacement)

, 
composite structure

About composite structure

, 
mixed construction

About mixed construction

, 
group (mathematics)

About group (mathematics)

, 
subset

About subset

, 
selectivity

About selectivity

, 
gastric mucosa

About gastric mucosa

, 
side effect

About side effect

, 
sulfonamide

About sulfonamide

, 
liposome

About liposome

, 
lactone

About lactone

, 
spiro-compound

About spiro-compound

, 
phenolic compound

About phenolic compound

, 
polynuclear aromatic compound

About polynuclear aromatic compound

, 
aminoalcohol

About aminoalcohol

, 
aminocarboxylic acid

About aminocarboxylic acid

, 
tertiary amine

About tertiary amine

, 
mixed construction

About mixed construction

, 
Cyclooxygenase 1

About Cyclooxygenase 1

, 
Cyclooxygenase 2

About Cyclooxygenase 2

, 
sub-group

About sub-group

, 
non-steroidal anti-inflammatory drug

About non-steroidal anti-inflammatory drug

, 
thin film

About thin film

, 
bilayer

About bilayer

, 
lipid membrane

About lipid membrane

, 
layer

About layer

, 
multilayer (molecule)

About multilayer (molecule)

, 
multilayer

About multilayer

, 
lipid bilayer membrane

About lipid bilayer membrane

, 
enzyme inhibitor

About enzyme inhibitor


Semi thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
non-steroidal anti-inflammatory agent

About non-steroidal anti-inflammatory agent

, 
hybrid structure

About hybrid structure

, 
*membrane permeability

About membrane permeability


JST classification (2)：
JST classification
Category name(code) classified by JST.
Basic research of anti-inflammatory drugs 
(GW15010T)

About Basic research of anti-inflammatory drugs

,  Transport of cell membrane 
(EF04020R)

About Transport of cell membrane

Terms in the title (5)：
Terms in the title
Keywords automatically extracted from the title.
膜透過性

About 膜透過性

, 
活性

About 活性

, 
セレコキシブ

About セレコキシブ

, 
ロフェコキシブ

About ロフェコキシブ

, 
構造活性相関

About 構造活性相関


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