Research theme for competitive and other funds (50)：
2020 - 2025 **
2021 - 2024 A multi-omics study to elucidate the novel molecular basis of the complex traits and ethnicity in Brugada syndrome
2020 - 2024 Multi-omics analysis in rare and intractable cardiovascular diseases to elucidate the pathogenesis and develop the precision medicine
2020 - 2023 Elucidation of molecular pathogenesis for inherited lethal arrhythmia associated with transporter abnormalities
2018 - 2022 Ethnicity-oriented genomic analysis of pathogenesis underlysing sudden cardiac death of unknown cause
2019 - 2022 Development of High Throughput Screening Technology to Functionally Validate VUSs of Cardiac Ion Channel Genes Responsible for Hereditary Lethal Arrhythmia
2019 - 2022 洞不全症候群の臨床情報・遺伝学的解析に基づくリスク層別化アルゴリズムの開発
2019 - 2022 *
2018 - 2021 Novel pathophysiology underlying cardiac conduction defect due to mutations of gap junction genes
2018 - 2021 Novel molecular basis underlying lethal arrhythmic syndrome due to mutations in cardiac Na/Ca exchanger gene
2018 - 2021 人種特異性に着目したゲノム解析による原因不明の心臓突然死の病態解明
2017 - 2020 Usefulness of histopathological evaluation for the diagnosis and prediction of clinical prognosis in patients with cardiomyopathy
2017 - 2019 先天性QT延長症候群スプライシング変異を標的とした創薬開発
2015 - 2018 Elucidation of novel pathophysiology underlysing lethal arrhythmia due to mutations in cardiac ion transporters
2015 - 2018 Novel molecular basis of cardriac conduction disturbance associated with a collagene gene mutation
2015 - 2018 Eludication of Genetic Risks for Sudden Cardiac Death and Development of Risk Stratification
2014 - 2017 Usefulness of endomyocardial biopsy for the diagnosis of dilated cardiomyopathy
2014 - 2017 Role of CaMKII in an experimental model of ventricular fibrillation storm
2008 - 2012 Regulation of mitochondrial ROS signaling in the cardiovascular stress response
2011 - 2011 進行性心臓伝導障害の病態診断と遺伝子基盤に関する研究
2009 - 2011 Mutations in cardiac gap junction genes and the pathophysiology underlying progressive cardiac conduction defect.
2009 - 2009 進行性心臓伝導障害の病態診断と遺伝子基盤に関する研究
2008 - 2008 致死性遺伝性不整脈疾患の遺伝子診断と臨床応用
2006 - 2007 Akt phosphorylation and arrhythmogenic modification of the cardiac sodium channel
2003 - 2004 Phamacogenomic studies for the genetic basis for lethal arrhythmias
2003 - 2003 致死性不整脈発症の分子基盤に関する調査・研究
2001 - 2002 Development and electrophysiological analysis of genetically engineered transgenic mice for Brugada syndrome.
1999 - 2001 A study forthe effects of estrogen on actions ofendothelium-derived hyperpolarizing factor
1999 - 2000 アデノウイルスベクターを用いた心筋イオンチャネル病の病態解明
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Papers (256)：
Jingshan Gao, Takeru Makiyama, Yuta Yamamoto, Takuya Kobayashi, Hisaaki Aoki, Thomas L Maurissen, Yimin Wuriyanghai, Asami Kashiwa, Tomohiko Imamura, Takanori Aizawa, et al. Novel Calmodulin Variant p.E46K Associated With Severe Catecholaminergic Polymorphic Ventricular Tachycardia Produces Robust Arrhythmogenicity in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circulation. Arrhythmia and electrophysiology. 2023. 16. 3. e011387
Yuki Nagata, Ryo Watanabe, Christian Eichhorn, Seiko Ohno, Takeshi Aiba, Taisuke Ishikawa, Yukiko Nakano, Yoshiyasu Aizawa, Kenshi Hayashi, Nobuyuki Murakoshi, et al. Targeted deep sequencing analyses of long QT syndrome in a Japanese population. PloS one. 2022. 17. 12. e0277242
Yoshiaki Kato, Yoshihiro Nozaki, Miho Takahashi-Igari, Masato Sugano, Naomasa Makita, Hitoshi Horigome. Progressive atrial myocardial fibrosis in a 4-year-old girl with atrial standstill associated with an SCN5A gene mutation. HeartRhythm case reports. 2022. 8. 9. 636-638
Asami Kashiwa, Takeru Makiyama, Hirohiko Kohjitani, Thomas L Maurissen, Taisuke Ishikawa, Yuta Yamamoto, Yimin Wuriyanghai, Jingshan Gao, Hai Huang, Tomohiko Imamura, et al. Disrupted Cav1.2 Selectivity Causes Overlapping Long QT and Brugada Syndrome Phenotypes in CACNA1C-E1115K iPS Cell Model. Heart rhythm. 2022. 20. 1. 89-99
Haruka Murakami, Yoko Tanimoto, Kojiro Tanimoto, Satomi Inoue, Taisuke Ishikawa, Naomasa Makita, Kazuki Yamazawa. Arrhythmogenic right ventricular cardiomyopathy in a Japanese patient with a homozygous founder variant of DSG2 in the East Asian population. Human genome variation. 2022. 9. 1. 28-28
Brugada Syndrome Risk Prediction
(Taiwan Heart Rhythm Society Autumn Forum 2021)
網羅的遺伝子解析と不整脈研究の進歩
(第57回日本小児循環器学会学術集会 2021)
Antisense-Mediated Knockdown of CALM as a Therapeutic Strategy for Calmodulinopathy
(67th Japanese Heart Rhythm Society 2021)
Torsadogenic Action of Late Sodium Current in Experimental Electrical Storm
(67th Japanese Heart Rhythm Society 2021)
Inhibition of Late Sodium Current Shortens Action Potential Durations in CACNA1C-E1115K iPS Cell Model with Disrupted Cav1.2 Ion Selectivity
(67th Japanese Heart Rhythm Society 2021)
