Rchr
J-GLOBAL ID:201501005029982242   Update date: Feb. 28, 2024

Takasugi Nobumasa

高杉 展正 | Takasugi Nobumasa
Affiliation and department:
Other affiliations (1):
Homepage URL  (1): https://www.okayama-u.ac.jp/user/yakko/
Research field  (2): Pharmaceuticals - health and biochemistry ,  Pharmacology
Research keywords  (5): lipid signaling ,  Amyloid beta ,  vesicular transport ,  Neurodegenerative disease ,  Alzheimer disease
Research theme for competitive and other funds  (9):
  • 2020 - 2023 GPCR-Amyloid precursor protein supercomplex regulate neural function
  • 2020 - 2023 小胞輸送障害の定量的・網羅的解析法の確立によるアルツハイマー病治療薬の探索
  • 2019 - 2022 APP-BACE1結合仲介分子によるアミロイドβ産生制御機構の解明
  • 2017 - 2020 Lipid flippase is the novel therapeutic target for the Alzheimer disease, which correlate with endocytic traffic impairment.
  • 2014 - 2017 Simultaneous control of the production and degradation of Amyloid be-ta by Sphingosine kinase/sphingosine-1-phosphate signaling
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Papers (31):
  • Masato Komai, Yuka Noda, Atsuya Ikeda, Nanaka Kaneshiro, Yuji Kamikubo, Takashi Sakurai, Takashi Uehara, Nobumasa Takasugi. Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Aβ uptake in astrocytes. Journal of Lipid Research. 2024
  • Atsushi Morimoto, Nobumasa Takasugi, Yuexuan Pan, Sho Kubota, Naoshi Dohmae, Yumi Abiko, Koji Uchida, Yoshito Kumagai, Takashi Uehara. Methyl vinyl ketone and its analogs covalently modify PI3K and alter physiological functions by inhibiting PI3K signaling. Journal of Biological Chemistry. 2024
  • Yuta Iijima, Ryohei Miki, Nobumasa Takasugi, Masatake Fujimura, Takashi Uehara. Characterization of pathological changes in the olfactory system of mice exposed to methylmercury. Archives of Toxicology. 2024
  • Rikako Taniguchi, Yuto Moriya, Naoshi Dohmae, Takehiro Suzuki, Kengo Nakahara, Sho Kubota, Nobumasa Takasugi, Takashi Uehara. Attenuation of protein arginine dimethylation via S-nitrosylation of protein arginine methyltransferase 1. Journal of Pharmacological Sciences. 2023
  • Kosaku Okuda, Kengo Nakahara, Akihiro Ito, Yuta Iijima, Ryosuke Nomura, Ashutosh Kumar, Kana Fujikawa, Kazuya Adachi, Yuki Shimada, Satoshi Fujio, et al. Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis. Nature Communications. 2023. 14. 1. 621-621
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MISC (14):
Patents (1):
  • アルツハイマー病予防治療薬のスクリーニング法
Education (1):
  • 1999 - 2003 東京大学大学院 薬学系研究科 薬学科
Professional career (1):
  • Ph.D. (The University of Tokyo)
Work history (6):
  • 2015/07 - 現在 Okayama University
  • 2012/04 - 2015/06 Juntendo University
  • 2010/10 - 2012/03 シカゴ大学 医学部 博士研究員
  • 2010/04 - 2010/09 東京大学大学院 医学系研究科 助教
  • 2008/04 - 2010/03 東京大学大学院 薬学系研究科 助教
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Committee career (3):
  • 2023/04 - 現在 日本薬学会薬理系薬学部会 会計実務
  • 2019 - 現在 日本薬理学会 学術評議員
  • 2018 - 2022 日本NO学会 庶務幹事
Awards (1):
  • 2023/10 - 公益財団法人両備檉園記念財団 生物学研究奨励賞
Association Membership(s) (5):
日本薬理学会 ,  北米神経科学学会 ,  THE PHARMACEUTICAL SOCIETY OF JAPAN ,  THE JAPANESE BIOCHEMICAL SOCIETY ,  JAPAN SOCIETY FOR DEMENTIA RESEARCH
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