Takasugi Nobumasa

高杉展正 | Takasugi Nobumasa

Affiliation and department：
Other affiliations (1)：

Homepage URL (1)： https://www.okayama-u.ac.jp/user/yakko/

Research field (2)： Pharmaceuticals - health and biochemistry , Pharmacology

Research keywords (5)： lipid signaling , Amyloid beta , vesicular transport , Neurodegenerative disease , Alzheimer disease

Research theme for competitive and other funds (9)：

2020 - 2023 GPCR-Amyloid precursor protein supercomplex regulate neural function
2020 - 2023 小胞輸送障害の定量的・網羅的解析法の確立によるアルツハイマー病治療薬の探索
2019 - 2022 APP-BACE1結合仲介分子によるアミロイドβ産生制御機構の解明
2017 - 2020 Lipid flippase is the novel therapeutic target for the Alzheimer disease, which correlate with endocytic traffic impairment.
2014 - 2017 Simultaneous control of the production and degradation of Amyloid be-ta by Sphingosine kinase/sphingosine-1-phosphate signaling

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Papers (36)：

Haruna Kurogi, Nobumasa Takasugi, Sho Kubota, Ashutosh Kumar, Takehiro Suzuki, Naoshi Dohmae, Daisuke Sawada, Kam Zhang, Takashi Uehara. Discovery of a Compound That Inhibits IRE1α S-Nitrosylation and Preserves the Endoplasmic Reticulum Stress Response under Nitrosative Stress. ACS Chemical Biology. 2024
Tomoki Tsuchida, Sho Kubota, Shizuki Kamiuezono, Nobumasa Takasugi, Akihiro Ito, Yoshito Kumagai, Takashi Uehara. Epigenetic Regulation of CXC Chemokine Expression by Environmental Electrophiles Through DNA Methyltransferase Inhibition. International Journal of Molecular Sciences. 2024
Ryohei Miki, Ryosuke Nomura, Yuta Iijima, Sho Kubota, Nobumasa Takasugi, Takao Iwawaki, Masatake Fujimura, Takashi Uehara. Therapeutic potential of 4-phenylbutyric acid against methylmercury-induced neuronal cell death in mice. Archives of Toxicology. 2024
Masato Komai, Yuka Noda, Atsuya Ikeda, Nanaka Kaneshiro, Yuji Kamikubo, Takashi Sakurai, Takashi Uehara, Nobumasa Takasugi. Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Aβ uptake in astrocytes. Journal of Lipid Research. 2024
Atsushi Morimoto, Nobumasa Takasugi, Yuexuan Pan, Sho Kubota, Naoshi Dohmae, Yumi Abiko, Koji Uchida, Yoshito Kumagai, Takashi Uehara. Methyl vinyl ketone and its analogs covalently modify PI3K and alter physiological functions by inhibiting PI3K signaling. Journal of Biological Chemistry. 2024

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MISC (14)：

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Patents (1)：

Education (1)：

Professional career (1)：

Work history (6)：

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Committee career (3)：

Awards (1)：

Association Membership(s) (5)：

日本薬理学会 , 北米神経科学学会 , THE PHARMACEUTICAL SOCIETY OF JAPAN , THE JAPANESE BIOCHEMICAL SOCIETY , JAPAN SOCIETY FOR DEMENTIA RESEARCH

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