Yoshihara Masahito

ヨシハラマサヒト | Yoshihara Masahito

Affiliation and department：
Job title： Associate Professor
Other affiliations (3)：

Chiba University Department of Artificial Intelligence Medicine, Graduate School of Medicine Associate Professor
Karolinska Institutet Department of Medicine, Huddinge (MedH) Visiting Researcher
Osaka University Premium Research Institute for Human Metaverse Medicine (PRIMe) Specially Appointed Professor

Homepage URL (2)： https://www.cn.chiba-u.jp/researcher/yoshihara_masahito/ , https://cn.chiba-u.jp/en/researcher/yoshihara_masahito/

Research field (5)： Systems genomics , Biological, health, and medical informatics , Genomics , Ophthalmology , Molecular biology

Research keywords (5)： induced pluripotent stem cells , Stem cells , regenerative medicine , Transcriptome , Bioinformatics

Research theme for competitive and other funds (10)：

2025 - 2028 Development of in vivo lens regeneration technology using lens stem cells for next-generation cataract treatment
2025 - 2028 関東三大学医学研究次世代育成プロジェクト
2025 - 2028 Elucidation of gene regulatory mechanisms during early human development using 8-cell-like cells
2023 - 2026 遺伝子治療実現に向けたヒト黄斑オルガノイドの開発
2023 - 2025 High-depth proteomic profiling of proliferative vitreoretinopathy

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Papers (49)：

Meryam Beniazza, Masahito Yoshihara, Daniel F Kaemena, James Ashmore, Suling Zhao, Michael O'Dwyer, Emil Andersson, Victor Olariu, Shintaro Katayama, Abdenour Soufi, et al. Hic2 fast-tracks iPS cell generation by suppressing KLF4-dependent epidermal detour. bioRxiv. 2025
Joonas Sokka, Ella Lapinsuo, Jouni Kvist, Sami Jalil, Masahito Yoshihara, Jere Weltner, Fredrik Lanner, Juha Kere, Diego Balboa, Timo Otonkoski, et al. Trophoblast stem cell derivation from naive and primed hPSC enables ELF5 functional analysis. Stem cell reports. 2025. 102637-102637
Masaki Shinohara, Masaki Ishikawa, Masahito Yoshihara, Ayako Yamazaki, Kenichiro Konishi, Ryo Konno, Shigemitsu Kojima, Shinya Takazawa, Akira Nishi, Takeshi Yamaguchi, et al. Proteome analysis of preserved formalin-fixed and paraffin-embedded specimens to explore the pathogenesis of infantile hypertrophic pyloric stenosis. Pediatric surgery international. 2025. 41. 1. 262-262
Rei Kamuro, Masahito Yoshihara, Susumu Hara, Takahiro Nemoto, Laura Howard, Ai Honda, Ayano Yamamoto, Toru Takigawa, Susumu Sakimoto, Koichi Baba, et al. PAX6-dependent differentiation landscape of ocular surface epithelium via single-cell RNA sequencing in hiPSC-derived ocular developmental organoid. Communications biology. 2025. 8. 1. 1220-1220
Masahito Yoshihara, Rei Kamuro, Susumu Hara, Nozomi Nishida, Koji Ohmoto, Yuzuru Sasamoto, Satoshi Kawasaki, Yoshinori Oie, Kohji Nishida. Transcriptional landscape of aniridia-associated keratopathy through single-cell RNA sequencing. The ocular surface. 2025. 38. 43-52

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MISC (24)：

Masahito Yoshihara. Uncovering Novel Transcriptional Enhancers in Neuronal Development and Neuropsychiatric Disorders. CHIBA UNIVERSITY : Press release. 2025
植田由依, 植田由依, 新居正基, 正谷憲宏, 正谷憲宏, 吉原正仁, 川上英良, 伊波勇輝, 北瀬悠磨, 鹿嶋晃平, et al. 先天性心疾患診療と人工知能(AI). 日本小児科学会雑誌. 2025. 129. 4
渡辺栄一郎, 渡辺栄一郎, 設楽佳彦, 紺野亮, 吉原正仁, 吉原正仁, 鹿島晃平, 伊藤淳, 向井丈雄, 木本豪, et al. 胎便タンパク質解析研究. 日本周産期・新生児医学会雑誌(Web). 2025. 61. Suppl.1
吉原正仁, 設楽佳彦, 渡辺栄一郎, 川島祐介, 紺野亮. 新生児のうんち(初回胎便)のタンパク質組成を解明 -性別、在胎週数、疾患の有無で異なる-. 千葉大学:プレスリリース. 2024
植田由依, 植田由依, 吉原正仁, 飯島雄太, 遠藤真美子, 大曽根義輝, 濱田洋通, 川上英良, 照井慶太, 照井慶太. 新生児全身X線画像のAI画像解析による疾患スクリーニングシステムの構築. 日本周産期・新生児医学会雑誌(Web). 2024. 60. Suppl.1

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Patents (2)：

CORNEAL ENDOTHELIAL CELL MARKER AND UTILIZATION THEREOF
Corneal endothelial cell marker

Books (7)：

ゲノム編集の最新技術と医薬品・遺伝子治療・農業・水畜産物・有用物質生産への活用
技術情報協会 2023 ISBN:9784861049781
Current Topics in iPSCs Technology
Academic Press / Elsevier 2022 ISBN:9780323998925
再生医療の開発戦略と最新研究事例集
技術情報協会 2019 ISBN:9784861047374
遺伝統計学と疾患ゲノムデータ解析 - 病態解明から個別化医療,ゲノム創薬まで -
メディカルドゥ 2018 ISBN:9784944157631
実験医学別冊最強のステップUPシリーズシングルセル解析プロトコールわかる!使える! 1細胞特有の実験のコツから最新の応用まで.
羊土社 2017 ISBN:9784758122344

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Lectures and oral presentations (41)：

Prediction of Gestational Age by Human Neonatal Meconium Proteome Analysis
(JPrOS2025(23rd JHUPO) Annual Meeting 2025)
RETFound Application: Improving Performance of Prognostic Model for Visual Prognosis in Retinitis Pigmentosa
(The 10th Asia Pacific Tele-Ophthalmology Society (APTOS) Symposium 2025 (APTOS 2025) 2025)
Metabolomic Profiling of Vitreous Humor in Proliferative Vitreoretinopathy
(2025)
Leveraging large-scale deep learning models for diagnosis and visual outcome prediction in retinitis pigmentosa patients
(The 5th Annual Meeting of the Japanese Society of Artificial Intelligence in Ophthalmology 2024)
Generation of 8-cell-like cells (8CLCs) from human pluripotent stem cells
(The 47th Annual Meeting of the Molecular Biology Society of Japan 2024)

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Education (3)：

2013 - 2017 Osaka University Graduate School of Medicine
2004 - 2010 Osaka University Faculty of Medicine
2001 - 2004 Rakunan High School

Professional career (2)：

M.D. (Osaka University)
Ph.D. (Osaka University)

Work history (13)：

2024/07 - 現在 Karolinska Institutet Department of Medicine, Huddinge (MedH) Visiting Researcher
2023/12 - 現在 Osaka University Premium Research Institute for Human Metaverse Medicine (PRIMe) Specially Appointed Professor
2022/04 - 現在 Chiba University Institute for Advanced Academic Research Associate Professor
2022/04 - 現在 Chiba University Graduate School of Medicine Department of Artificial Intelligence Medicine Associate Professor
2022/04 - 2024/07 Karolinska Institutet Department of Biosciences and Nutrition Visiting Researcher

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Awards (2)：

2015/09 - RIKEN SUMMER SCHOOL 2015 POSTER AWARD MEDICAL SCIENCE PRIZE
2010/03 - Osaka University Kusumoto Award (The top graduate)

Association Membership(s) (6)：

JAPANESE OPHTHALMOLOGICAL SOCIETY , JAPANESE SOCIETY FOR BIOINFORMATICS , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , 日本角膜学会 , Japanese Association for Medical Artificial Intelligence , International Society for Stem Cell Research (ISSCR)

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