Nakamura Norimasa

ナカムラノリマサ | Nakamura Norimasa

Homepage URL (1)： https://kaken.nii.ac.jp/d/r/50273719.ja.html

Research field (5)： Orthopedics , Rehabilitation science , Biomaterials , Biomedical engineering , Sports science

Research keywords (28)：スキャフォールド , 幹細胞 , 軟骨分化 , 再生医療 , メカニカルストレス , 骨分化 , 軟骨再生 , 組織工学 , 細胞移植 , 骨再生 , 骨形成因子 , ハイドロキシアパタイト , 3次元化 , iPS cell , Scaffold , ES cell , 接着能 , scaffold free , 滑膜細胞 , Stem cell , メカノトランスダクション , 力学刺激 , 間葉系幹細胞 , 三次元培養 , 膝十字靱帯損傷 , 運動器 , 運動器細胞 , 下腿抵抗

Research theme for competitive and other funds (21)：

2023 - 2026 細胞外小胞を徐放するナノファイバースキャフォールドを用いた新規半月板治療法の開発
2022 - 2026 変形性関節症に対する間葉系間質細胞由来セクレトーム治療における作用機序の解明
2020 - 2023 生体と類似構造を有する三次元骨軟骨組織を用いた新規変形性関節症治療法の開発
2019 - 2022 Development of a safe and efficient methods for the collection of mesenchymal stem cell-derived extracellular vesichles for the treatment of osteoarthritis
2015 - 2019 Development of cartilage regeneration technology by scaffold-free three-dimensional artificial tissue derived from human iPS cells

2016 - 2019 ナノ周期構造・ナノ繊維構造を用いた幹細胞由来組織再生材料の高度化と軟骨修復

2014 - 2018 細胞を用いた機能的な立体組織および立体臓器作製技術の研究開発/高機能足場素材とバイオ3Dプリンタを用いた再生組織・臓器の製造技術の開発

2014 - 2017 Optimization of regeneration technique for bone and cartilage derived from iPS cells

2013 - 2016 Development of a stem cell-based self-assembled tissue cultured on a nano-periodic-patterned surface: Fiber reinforcement and improvement of soft tissue repair

2012 - 2016 Development of the safe and effective knee extensor muscle training for the knee joint disorder.

2004 - 2015 無血清培養法により製造した同種滑膜間葉系幹細胞由来三次元人口組織の薬事承認申請に質する非臨床試験

2011 - 2014 Mechano-signal transduction against 3-D mechanical stress in human connective tissue cells and MCS

2010 - 2014 Cartilage repair using a scaffold free tissue engineered construct derived from multipotent stem cell

2010 - 2014 生体内で自律的に成熟する臓器再生デバイスのための評価技術研究開発

2010 - 2014 生体内で自律的に成熟する臓器再生デバイスのための基盤研究開発

2011 - 2012 Induction of differentiation to musculoskeletal tissue with autologous blood-derived scaffold and application to regenerative medicine

2010 - 2012 Motion analysis of anterior cruciate ligament insufficient knee during sports activities.

2007 - 2009 Osteochondral regeneration using a scaffold-free tissue engineered construct (TEC) derived from mesenchymal stem cells

2007 - 2009 The development of noninvasive and economical method to evaluate the bone quality using the measurement of serum levels of osteocyte-specific-proteins

2007 - 2008 Effects of mechanical stimulation on cells derived from synovial joint

2004 - 2006 Development of a novel technology using mesenchymal stem cells from synovium for bone and cartilage regeneration.

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Papers (259)：

Kazunori Shimomura, Wataru Ando, David A. Hart, Norimasa Nakamura. A novel scaffold-free mesenchymal stem cell-derived tissue engineered construct for articular cartilage restoration - From basic to clinic. Regenerative Therapy. 2024. 26. 124-131
Akira Tsujii, Hiroto Hanai, Tomoki Ohori, David A. Hart, Norimasa Nakamura. Next-Generation Cartilage Repair Solutions: Where Are We?. Sports Injuries. 2024. 1-21
下村和範, 渡辺淳也, 鈴木智之, 中川晃一, 岩崎潤一, 中島歩, 松本昌也, 瀬川耕太郎, 辻井聡, 中村憲正. 同種滑膜間葉系幹細胞由来三次元人工組織を用いた第III相膝関節軟骨再生臨床試験. 日本整形外科学会雑誌. 2024. 98. 2. S30-S30
Akira Tsujii, Tomoki Ohori, Hiroto Hanai, Norimasa Nakamura. NextGen approaches for cartilage repair and joint preservation. Journal of Cartilage & Joint Preservation. 2024. 100177-100177
Shinichi Nakagawa, Wataru Ando, Kazunori Shimomura, David A. Hart, Hiroto Hanai, George Jacob, Ryota Chijimatsu, Seido Yarimitu, Hiromichi Fujie, Seiji Okada, et al. Repair of osteochondral defects: efficacy of a tissue-engineered hybrid implant containing both human MSC and human iPSC-cartilaginous particles. npj Regenerative Medicine. 2023. 8. 1

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MISC (317)：

木村佳記, 下村和範, 中村憲正. 膝軟骨再生医療と理学療法 (知っておきたい深めたい Close-up 理学療法士は再生医療に向き合えているか). 理学療法ジャーナル. 2020. 54. 8. 940-943
Ryohei Uchida, George Jacob, Kazunori Shimomura, Shuji Horibe, Norimasa Nakamura. Biological Augmentation of ACL Repair and Reconstruction: Current Status and Future Perspective. Sports medicine and arthroscopy review. 2020. 28. 2. 49-55
内田良平, 中村憲正, 星野祐一, 北田真平, 西澤勇一郎, 北圭介, 米田憲司, 藤田健司. アメリカンフットボールにおける脳振盪発生時の状況動画による解析. 日本臨床スポーツ医学会誌. 2019. 27. 4. S210-S210
西澤勇一郎, 内田良平, 中村憲正, 星野祐一, 北田真平, 北圭介, 米田憲司, 藤田健司. アメリカンフットボールにおける脳振盪発生時の接触状況動画による解析. 日本臨床スポーツ医学会誌. 2019. 27. 4. S210-S210
中村憲正. スポーツ医学イノベーション継承と革新軟骨の再生医療. 日本整形外科スポーツ医学会雑誌. 2018. 38. 3. 223-227

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Patents (3)：

Scaffold-free self organized 3D synthetic tissue
Scaffold-free self organized 3D synthetic tissue
Scaffold-free self-organized 3D synthetic tissue

Books (10)：

ゼロからはじめる! Knee Osteotomyアップデート
全日本病院出版会 2018 ISBN:9784865192452
Bio-orthopaedics
2017 ISBN:9783662541807
Controversies in the Technical Aspects of ACL Reconstruction An Evidence-Based Medicine Approach
Springer 2017
Muscle and tendon injuries : evaluation and management
Springer 2017 ISBN:9783662541838
DeLee & Drez's orthopaedic sports medicine : principles and practice : set
Elsevier/Saunders 2015 ISBN:9781455743766

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Education (2)：

1990 - 1994 Osaka University
1982 - 1988 Osaka University Faculty of Medicine Medical School

Professional career (1)：

医学博士 (大阪大学)

Work history (10)：

2018/09 - 現在北京大学 (中国) 医学部整形外科スポーツ医科学客員教授
2014/04 - 現在 Hokkaido University Graduate School of Medicine
2009/04 - 現在 Osaka Health Science University
2009/04 - 現在 Osaka University Global Center for Medical Engineering and Informatics
2007/07 - 2009/03 Osaka University Graduate School of Medicine

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Awards (18)：

2016/09 - International Cartilage Repair Society Best Rated Abstract Award
2013/09 - International Cartilage Repair Society Best Rated Abstract Award
2012/03 - Journal of Biomedical Science and Engineering Best Paper Award
2010/10 - 日本バイオメカニクス学会学会奨励賞
2010/10 - International Cartilage Repair Society Certificate of Merit

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