Rchr
J-GLOBAL ID:201501007018614597   Update date: Jan. 31, 2024

Nakaya Takeo

ナカヤ タケオ | Nakaya Takeo
Affiliation and department:
Homepage URL  (1): https://kaken.nii.ac.jp/d/r/80512277.ja.html
Research field  (4): Experimental pathology ,  Tumor biology ,  Pharmaceuticals - chemistry and drug development ,  Human pathology
Research keywords  (13): がん分子創薬 ,  創薬病理学 ,  大腸癌 ,  蛋白間相互作用阻害薬 ,  病理診断学 ,  New Cancer Therapy ,  Stem cell ,  腫瘍抑制 ,  がん ,  KLF5 ,  EBウイルス ,  癌幹細胞 ,  LMP2A
Research theme for competitive and other funds  (11):
  • 2023 - 2026 Elucidation of the mechanism of myocardial energy metabolism regulation by NC compound, a KLF5 inhibitor with a beneficial effect on heart failure.
  • 2020 - 2024 膵癌リンパ管侵襲の病態解明とそれを抑制する新規治療法の開発
  • 2019 - 2023 癌を選択的に抑制しかつ心機能を改善するKLF5阻害薬の開発とその分子作用機序解明
  • 2018 - 2021 Molecular mechanism of familial aortic dissection by smooth muscle myosin mutation and elucidation of vascular aging mechanism
  • 2016 - 2020 Elucidation of the KLF protein complex in intestinal tissues and development of new drugs to suppress protein-protein interactions for the treatment of colorectal cancer
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Papers (37):
  • Kentaro Tsuji, Hirotoshi Kawata, Tomoko Kamiakito, Takeo Nakaya, Akira Tanaka. RNA-binding protein 14 promotes phase separation to sustain prostate specific antigen expression under androgen deprivation in human prostate cancer. The Journal of steroid biochemistry and molecular biology. 2023. 235. 106407-106407
  • Kiyokuni Tanabe, Kensuke Yokoyama, Atsushi Kanno, Eriko Ikeda, Kozue Ando, Hiroki Nagai, Takahiro Koyanagi, Mio Sakaguchi, Takeo Nakaya, Kiichi Tamada, et al. Immune Checkpoint Inhibitor-induced Pancreatitis with Pancreatic Enlargement Mimicking Autoimmune Pancreatitis: A Case Report and Review of the Literature. Internal medicine (Tokyo, Japan). 2023
  • Yuma Horii, Shoichi Matsuda, Chikashi Toyota, Takumi Morinaga, Takeo Nakaya, Soken Tsuchiya, Masaki Ohmuraya, Takanori Hironaka, Ryo Yoshiki, Kotaro Kasai, et al. VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid-liquid phase separation. Nature Communications. 2023. 14. 1
  • 仲矢 丈雄, 相澤 健一, 田口 由起, 辻 賢太郎, 關根 沙知, 村上 知弘, 近藤 恭光, 旦 慎吾, 吉森 篤史, 小路 弘行, et al. がん創薬の新しい潮流 天然変性蛋白かつ核内因子であるがん関連転写因子KLF5を標的とした低分子化合物の開発(Development of low-molecular-weight compounds targeting the cancer-associated KLF5 transcription factor). 日本癌学会総会記事. 2022. 81回. S10-6
  • Hiroka Iwata, Koji Kamiya, Soichiro Kado, Takeo Nakaya, Hirotoshi Kawata, Mayumi Komine, Mamitaro Ohtsuki. Case of immunoglobulin A vasculitis following coronavirus disease 2019 vaccination. The Journal of dermatology. 2021. 48. 12. e598-e599
more...
MISC (3):
Books (4):
  • Precision Medicine
    2018
  • 化学
    化学同人 2012
  • 病理画像診断これでスッキリ!
    メジカルビュー 2012
  • がんプロフェッショナル養成講座 腫瘍病理学
    文光堂 2008
Lectures and oral presentations  (4):
  • Small molecules mimicking KLF5 structure suppresses cancer cells in both in vivo and vitro without damaging normal cells.
    (6th International Conference on Biology and Pathobiology of KLF/Sp Transcription Factors 2018)
  • Small mimicries of KLF5 selectively suppress the survival and Wnt-KLF5 signal of colorectal cancer.
    (2017)
  • The protein interaction inhibitors of KLF5 suppress Wnt signal activation selectively in colorectal cancer cells.
    (2016)
  • The protein interaction inhibitors of KLF5 suppress Wnt signal activation selectively in colorectal cancer cells.
    (FASEB SRC, KLF and SP Transcription Factors In Disease And Regenerative Medicine 2016)
Professional career (1):
  • 博士(医学) (東京大学)
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