Tomita Takuro

トミタタクロウ | Tomita Takuro

Affiliation and department：
Job title：准教授
Homepage URL (1)： https://kaken.nii.ac.jp/d/r/60705060.ja.html

Research field (2)： Medical biochemistry , Dermatology

Research theme for competitive and other funds (13)：

2022 - 2026 無痛症のメカニズムの解明:生体内におけるNaV1.7変異が与える影響
2024 - 2025 Elucidation of molecular mechanism for depolarization-induced Ca2+ release using novel reconstitution system
2022 - 2025 出生後心臓の冠血管・交感神経ネットワーク形成の原理と心臓発達における重要性の解明
2022 - 2023 動脈硬化におけるCaV1.2のC末端リン酸化の重要性解明と創薬展開
2022 - 2023 CaV1.2のY1709リン酸化の動脈硬化における重要性解明

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Papers (43)：

Takashi Murayama, Nagomi Kurebayashi, Takuro Numaga-Tomita, Takuya Kobayashi, Satoru Okazaki, Kyosuke Yamashiro, Tsutomu Nakada, Shuichi Mori, Ryosuke Ishida, Hiroyuki Kagechika, et al. A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery. The Journal of general physiology. 2022. 154. 12
Sayaka Oda, Kazuhiro Nishiyama, Yuka Furumoto, Yohei Yamaguchi, Akiyuki Nishimura, Xiaokang Tang, Yuri Kato, Takuro Numaga-Tomita, Toshiyuki Kaneko, Supachoke Mangmool, et al. Myocardial TRPC6-mediated Zn2+ influx induces beneficial positive inotropy through β-adrenoceptors. Nature communications. 2022. 13. 1. 6374-6374
Takuro Numaga-Tomita, Tsukasa Shimauchi, Yuri Kato, Kazuhiro Nishiyama, Akiyuki Nishimura, Kosuke Sakata, Hiroyuki Inada, Satomi Kita, Takahiro Iwamoto, Junichi Nabekura, et al. Inhibition of transient receptor potential cation channel 6 promotes capillary arterialization during post-ischaemic blood flow recovery. British journal of pharmacology. 2022. 180. 1. 94-110
Tsukasa Shimauchi, Takuro Numaga-Tomita, Yuri Kato, Hiroyuki Morimoto, Kosuke Sakata, Ryosuke Matsukane, Akiyuki Nishimura, Kazuhiro Nishiyama, Atsushi Shibuta, Yutoku Horiuchi, et al. A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind-Limb Ischemia. Cells. 2022. 11. 13
Hiroyuki Kawagishi, Tsutomu Nakada, Takuro Numaga-Tomita, Maite Larrañaga, Ang Guo, Long-Sheng Song, Mitsuhiko Yamada. Cytokine receptor gp130 promotes postnatal proliferation of cardiomyocytes required for the normal functional development of the heart. American Journal of Physiology-Heart and Circulatory Physiology. 2022

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MISC (6)：

酒田康介, 島内司, 冨田拓郎, 加藤百合, 西山和宏, 西村明幸, 西田基宏. マウス下肢虚血後の毛細血管動脈化におけるTRPC6チャネルの役割. 日本薬学会年会要旨集. 2022. 142年会. 26K-am05S
Takuro Numaga-Tomita, Motohiro Nishida. TRPC Channels in Cardiac Plasticity. Cells. 2020. 9. 2
川岸裕幸, 柏原俊英, 冨田拓郎, 中田勉, 山田充彦. アンジオテンシンII1型受容体-βアレスチン経路を活性化する小児心不全治療薬の開発. 日本循環薬理学会口演要旨集. 2020. 30th
冨田拓郎, 五味志文, 柏原俊英, 中田勉, 山田充彦. Molecular mechanisms underlying the agonistic effect of FPL 64176 on Cav1.2 Ca²⁺ channels. 日本薬理学雑誌. 2020. 155. Supplement
川岸裕幸, 川岸裕幸, 柏原俊英, 冨田拓郎, 中田勉, 山田充彦. βアレスチンバイアスアンジオテンシン1型受容体アゴニストは,新生児特有の持続性陽性変力作用を示す. 日本薬理学雑誌. 2020. 155. Supplement

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Patents (1)：

ベンゾイソオキサゾール化合物

Lectures and oral presentations (13)：

The importance of sympathetic innervation for the postnatal heart development
(2023)
Pathophysiological importance of C-terminal tyrosine phosphorylation of CaV1.2 in vessel remodeling
(2022)
Molecular mechanism configuring CaV1.2 Ca2+ channel current in cardiac ventricular action potential.
(2022)
交感神経除神経が新生児・乳児の心臓発達に与える影響の解析
(第31回日本循環薬理学会 2021)
The effect of chemical sympathetic innervation on the postnatal heart development
(2021)

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Work history (7)：

2019/05 - 現在信州大学医学部分子薬理学教室准教授
2018/04 - 2019/04 自然科学研究機構・生命創成探究センター心循環ダイナミズム創発研究部門助教
2014/04 - 2018/03 自然科学研究機構・岡崎統合バイオサイエンスセンター心循環シグナル研究部門助教
2013/03 - 2014/03 Kyushu University
2012/09 - 2013/02 National insitute of environmental health sciences Laboratory of Signal Transduction

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Committee career (2)：

2021/03 - 現在日本薬理学会評議員
2021/03 - 現在日本生理学会評議員

Awards (5)：

2022/12 - 第96回日本薬理学会年会優秀ポスター賞
2019/03 - 日本生理学会入澤宏・彩記念若手研究奨励賞
2017/05 - 日本NO学会 Young Investigator Award
2016/07 - International and Interdisciplinary symposium 2016 Best Poster Award
2016/05 - 日本NO学会トラベルアワード

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