Ito Keisuke

イトウケイスケ | Ito Keisuke

Affiliation and department：
Job title： Assistant Professor

Research field (1)： Developmental biology

Research theme for competitive and other funds (6)：

2022 - 2025 前肢に存在する「神経様細胞」の異常産生と、神経芽腫発症の共通分子基盤を探る
2019 - 2022 Analysis of multipotency and its underlying molecular mechanisms of sympathetic nerve-associating Schwann cell precursors
2015 - 2017 RET生体可視化ツールを用いた、発生と病理における受容体輸送研究
2017 - 神経芽腫に対する新規治療剤の探索
2010 - 2015 Vascular tissues that supports migration of enteric neural progenitors

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Papers (9)：

Bayu Pratama Putra, Keisuke Ito, Carla Cirillo, Mukhamad Sunardi, Haruhiko Koseki, Toshihiro Uesaka, Hideki Enomoto. Pcgf1 gene disruption reveals primary involvement of epigenetic mechanism in neuronal subtype specification in the enteric nervous system. Development, growth & differentiation. 2023
Mukhamad Sunardi, Keisuke Ito, Yuya Sato, Toshihiro Uesaka, Mitsuhiro Iwasaki, Hideki Enomoto. A single RET mutation in Hirschsprung disease induces intestinal aganglionosis via a dominant-negative mechanism. Cellular and Molecular Gastroenterology and Hepatology. 2022. 15. 6. 1505-1524
Mukhamad Sunardi, Keisuke Ito, Hideki Enomoto. Live visualization of a functional RET-EGFP chimeric receptor in homozygous knock-in mice. Development, Growth & Differentiation. 2021. 63. 6. 285-294
Mitsumasa Okamoto, Toshihiro Uesaka, Keisuke Ito, Hideki Enomoto. Increased RET Activity Coupled with a Reduction in the RET Gene Dosage Causes Intestinal Aganglionosis in Mice. eneuro. 2021. 8. 3. ENEURO.0534-20.2021
Keisuke Ito, Hideki Enomoto. Retrograde transport of neurotrophic factor signaling: implications in neuronal development and pathogenesis. Journal of Biochemistry. 2016. 160. 2. 77-85

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MISC (2)：

Keisuke Ito, Takahiko Kawasaki, Tatsurni Hirata. Repulsive effect of Sema3F on lot cells, the guidepost neurons in the lateral olfactory tract. NEUROSCIENCE RESEARCH. 2007. 58. S38-S38
Keisuke Ito, Takahiko Kawasaki, Tatsumi Hirata. Effect of a protein kinase inhibitor, K252a on migratory neurons. NEUROSCIENCE RESEARCH. 2006. 55. S216-S216

Lectures and oral presentations (25)：

Schwann cell precursor-derived sympathoadrenal cells and their contribution to neuroblastoma
(第7回 CREST多細胞領域会議 2025)
全身に分布する神経芽腫の潜在的起源シュワン前駆細胞由来の異所性交感副腎細胞について
(第12回神戸横浜熊本交流会(六花の会) 2025)
Sox10 haploinsufficiency systemically induces ectopic sympathetic neurogenesis through Schwann cell precursors
(APPW2025 2025)
Systemic aberrant sympathetic neurogenesis driven by Schwann cell precursors and its role in neurocristopathy
(RIKEN BDR Symposium 2025 2025)
Genetic Manipulation of Nodose Ganglion Neuron Subtypes
(第6回 CREST多細胞領域会議 2024)

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Education (1)：

Professional career (2)：

Awards (1)：

2014/01 - 理化学研究所理化学研究所基礎科学・国際特別研究員研究成果発表会ポスター賞 Analysis of Physiological Meanings of Intracellular Trafficking of the Neurotrophic Receptor, RET - Focusing on Development of the Enteric Nervous System

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