KOHJI MORI

モリコウジ | KOHJI MORI

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： https://www.med.osaka-u.ac.jp/pub/psy/laboratories/lab01/

Research field (2)： Neuropathology , Psychiatry

Research keywords (7)： RAN翻訳 , リピート病 , RNA , 老年精神医学 , 神経変性疾患 , 前頭側頭型認知症 , 前頭側頭葉変性症

Research theme for competitive and other funds (11)：

2024 - 2027 前頭側頭型認知症における自然免疫とRNA分解系のクロストーク
2021 - 2027 動的異常翻訳のメカニズムとその病的意義
2022 - 2025 自閉スペクトラム症における異常伸長リピート翻訳の病的意義
2022 - 2025 Development of Alzheimer disease biomarker
2020 - 2025 Elucidation of molecular mechanisms of repeat-associated non-AUG translation and its role in neurodegenerative diseases

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Papers (51)：

Ryota Uozumi, Kohji Mori, Shoshin Akamine, Manabu Ikeda. Protocols for identifying endogenous interactors of RNA-binding proteins in mammalian cells using the peroxidase APEX2 biotin-labeling method. STAR Protocols. 2024
Masahiro Hata, Yuki Miyazaki, Kohji Mori, Kenji Yoshiyama, Shoshin Akamine, Hideki Kanemoto, Shiho Gotoh, Hisaki Omori, Atsuya Hirashima, Yuto Satake, et al. Utilizing portable electroencephalography to screen for pathology of Alzheimer’s disease: a methodological advancement in diagnosis of neurodegenerative diseases. Frontiers in Psychiatry. 2024. 15
Masataka Kikuchi, Justine Viet, Kenichi Nagata, Masahiro Sato, Geraldine David, Audic Yann, Michael A. Silverman, Mitsuko Yamamoto, Hiroyasu Akatsu, Yoshio Hashizume, et al. Gene-gene functional relationships in Alzheimer’s disease: CELF1 regulates KLC1 alternative splicing. Biochemical and Biophysical Research Communications. 2024. 150025-150025
Ryota Uozumi, Kohji Mori, Shiho Gotoh, Tesshin Miyamoto, Shizuko Kondo, Tomoko Yamashita, Yuya Kawabe, Shinji Tagami, Shoshin Akamine, Manabu Ikeda. PABPC1 mediates degradation of C9orf72-FTLD/ALS GGGGCC repeat RNA. iScience. 2024. 27. 3. 109303-109303
Shiho Gotoh, Kohji Mori, Yuzo Fujino, Yuya Kawabe, Tomoko Yamashita, Tsubasa Omi, Kenichi Nagata, Shinji Tagami, Yoshitaka Nagai, Manabu Ikeda. eIF5 stimulates the CUG initiation of RAN translation of poly-GA dipeptide repeat protein (DPR) in C9orf72 FTLD/ALS. Journal of Biological Chemistry. 2024. 300. 3. 105703-105703

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MISC (85)：

宮本勝哉, 繁信和恵, 森康治, 佐竹祐人, 山下里佳, 別宮豪一, 村山繁雄, 池田学. 発症から緩やかな経過を経て死亡し,病理解剖にて左優位の意味性認知症の確定診断に至った1例. 精神神経学雑誌. 2024. 126. 2. 147-147
宮本哲愼, 森康治, 魚住亮太, 後藤志帆, 近藤志都子, 赤嶺祥真, 佐竹祐人, 佐藤俊介, 鐘本英輝, 吉山顕次, et al. 阪大精神科認知症コホートにおけるNOTCH2NLC遺伝子GGCリピート長の解析. Dementia Japan. 2023. 37. 4. 665-665
藤野雄三, 上山盛夫, 石黒太郎, 小澤大作, 伊藤隼人, 石黒亮, 森康治, 池田学, 水野敏樹, 望月秀樹, et al. FUSはRNAシャペロンとしてRAN翻訳を抑制し,C9orf72関連ALS/FTDの神経変性を改善する. Dementia Japan. 2023. 37. 4. 653-653
魚住亮太, 森康治, 後藤志帆, 宮本哲愼, 近藤志都子, 山下智子, 河邉有哉, 田上真次, 赤嶺祥真, 池田学. 近接標識プロテオミクスによるC9orf72-GGGGCCリピートRNA分解タンパク質の同定. Dementia Japan. 2023. 37. 4. 653-653
宮本哲愼, 森康治, 魚住亮太, 後藤志帆, 近藤志都子, 赤嶺祥真, 佐竹祐人, 佐藤俊介, 鐘本英輝, 吉山顕次, et al. 阪大精神科認知症コホートにおけるNOTCH2NLC遺伝子GGCリピート長の解析. Dementia Japan. 2023. 37. 4. 665-665

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Patents (1)：

Dipeptide-repeat proteins as therapeutic target in neurodegenerative diseases with hexanucleotide repeat expansion

Books (4)：

Annual Review 神経 2021
中外医薬社 2021
神経変性疾患ハンドブック : 神経難病へのエキスパート・アプローチ
南江堂 2018 ISBN:9784524256174
認知症学とマネジメント
ワールドプランニング 2009 ISBN:9784863510142
絵でみる心の保健室
アルタ出版 2007 ISBN:9784901694254

Lectures and oral presentations (166)：

Screening for factors that differentially regulate conventional translation and RAN translation in C9orf72-FTLD/ALS
(International Society for Frontotemporal Dementias (ISFTD2024), 19-22th Sep, 2024, Amsterdam, The Netherlands)
eIF5 enhances poly-GA RAN translation in C9orf72 FTLD/ALS models
(International Society for Frontotemporal Dementias (ISFTD2024), 19-22th Sep, 2024, Amsterdam, The Netherlands)
Utility of case review meetings in Japanease FTD Consortium FTLD-J
(International Society for Frontotemporal Dementias (ISFTD2024), 19-22th Sep, 2024, Amsterdam, The Netherlands 2024)
Regulatory differences between conventional translation and C9orf72 RAN translation
(Repeat Expansion Disorders: Unveiling New Aspects of the Central Dogma 2024)
(シンポジウム)遺伝性前頭側頭型認知症の臨床と病態
(第38会秋季日本老年精神医学会 2023)

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Education (2)：

- 2010 Osaka University Graduate School of Medicine Division of Internal Medicine
- 2004 Ehime University School of Medicine Faculty of Medicine

Work history (11)：

2022/07 - 現在 Osaka University Graduate School of Medicine Associate Professor
2018/10 - 2022/06 Osaka University School of Medicine Associate Professor (concurrent position)
2015/12 - 2022/06 Osaka University Graduate School of Medicine Assistant Professor
2011/10 - 2015/11 LMU Munich Postdoc
2010/04 - 2011/09 Osaka General Medical Center Attending Psychiatrist

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Committee career (6)：

2023/03 - 現在日本神経化学会評議員
2022/05 - 現在日本精神神経学会精神科専門医テキスト作成委員会委員
2022 - 現在日本認知症学会代議員
2022 - 現在日本老年精神医学会生涯教育講座部会委員
2017 - 現在近畿精神神経学会評議員

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Awards (8)：

2023/12 - 老年・認知症meeting presentation award, Silver prize
2021/11 - Japan Society for Dementia Research Award
2021/11 - Medical Research Encouragement Prize of The Japan Medical Association
2021/10 - The Award for Distinguished Investigator of Japanese Society for Neurochemistry
2019/12 - 先進医薬研究振興財団第3回先進医薬研究報告会精神薬療分野最優秀若手研究者

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Association Membership(s) (8)：

JAPANESE PSYCHOGERIATRIC SOCIETY , JAPANESE SOCIETY OF BIOLOGICAL PSYCHIATRY , 日本神経化学会 , JAPAN SOCIETY FOR DEMENTIA RESEARCH , 日本精神神経学会 , The Japanese Society of Neuropathology , The Japanese Society of Schizophrenia Research/JSSR , International Society for Frontotemporal Dementias

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