Rchr
J-GLOBAL ID：201501016433278568   Update date: Apr. 12, 2024

Okada Seiji

オカダ セイジ | Okada Seiji
Affiliation and department：
Kumamoto University Joint Research Center for Human Retrovirus Infection

About Kumamoto University Joint Research Center for Human Retrovirus Infection


Job title： Professor
Other affiliations (1)：
Homepage URL  (1)： https://kaken.nii.ac.jp/d/r/50282455.ja.html
Research field  (7)： Hematology and oncology ,  Experimental pathology ,  Immunology ,  Laboratory animal science ,  Pathobiochemistry ,  Cardiology ,  Orthopedics
Research keywords  (28)： トランスジェニックマウス ,  アポトーシス ,  造血幹細胞 ,  IL-5 ,  転写抑制 ,  BAZF ,  リンパ腫 ,  転写因子 ,  AP-1 ,  c-fos ,  B細胞 ,  Bcl6 ,  マクロファージ ,  癌 ,  リンパ球 ,  精母細胞 ,  樹状細胞 ,  造血器腫瘍 ,  免疫不全マウス ,  動物モデル ,  欠損マウス ,  高度免疫不全マウス ,  血球分化 ,  造血微小環境 ,  血液悪性腫瘍 ,  ストロマ細胞 ,  トランスジェニックマウ ,  Cepharanthine
Research theme for competitive and other funds  (48)：
  • 2022 - 2025 Development of novel HIV-1 capsid (CA) inhibitors, and determination regarding novel mechanism of CA uncoating
  • 2022 - 2025 原発性滲出性悪性リンパ腫の病態解析に基づいた治療法開発
  • 2020 - 2023 Elucidation of the mechanism of maturation of tertiary lymph structure in gastric cancer tumor immune microenvironment and identification of the therapeutic antibodies
  • 2018 - 2022 Multistep carcinogenesis mechanism of renal cell carcinoma using human iPS cell-derived nephron induction and development of therapeutic platform
  • 2016 - 2020 Elucidation of the hypoxic immune response and its application to multidisciplinary therapy
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Papers (338)：
  • KODCHARAT CHEEVAPRUK, MIKINORI UENO, PRIN SUNGWAN, GUNYA SITTITHUMCHAREE, RYUSHO KARIYA, SOMPONNAT SAMPATTAVANICH, SEIJI OKADA. Novel Midkine Inhibitor Induces Cell Cycle Arrest and Apoptosis in Multiple Myeloma. Anticancer Research. 2024. 44. 3. 1023-1031
  • Tatsuro Watanabe, Yuta Yamamoto, Yuki Kurahashi, Kazunori Kawazoe, Keisuke Kidoguchi, Hiroshi Ureshino, Kazuharu Kamachi, Nao Yoshida-Sakai, Yuki Fukuda-Kurahashi, Hideaki Nakamura, et al. Reprogramming of pyrimidine nucleotide metabolism supports vigorous cell proliferation of normal and malignant T cells. Blood advances. 2024
  • Yuki Seki, Keisuke Yamana, Ryoji Yoshida, Junki Inoue, Kosuke Shinohara, Toru Oyama, Ryuta Kubo, Masashi Nagata, Kenta Kawahara, Masatoshi Hirayama, et al. Programmed death-ligand 1-expressing extracellular vesicles are a prognostic factor in patients with oral squamous cell carcinoma treated with immune checkpoint inhibitors. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2024
  • Naoto Yoshimura, Ryusho Kariya, Masaki Shimada, Makoto Tateyama, Hideto Matsunaga, Yuto Shibata, Shuntaro Tanimura, Kosei Takata, Takahiro Arima, Junki Kawakami, et al. The IL-17-IL-17RA axis is required to promote osteosarcoma progression in mice. Scientific reports. 2023. 13. 1. 21572-21572
  • Yasushi Kubota, Toshimi Hoshiko, Taishi Higashi, Keiichi Motoyama, Seiji Okada, Shinya Kimura. Folate-Appended Hydroxypropyl-β-Cyclodextrin Induces Autophagic Cell Death in Acute Myeloid Leukemia Cells. International Journal of Molecular Sciences. 2023. 24. 23. 16720-16720
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MISC (224)：
  • 渡邉達郎, 吉田(坂井)奈央, 吉田(坂井)奈央, 山本雄大, 嬉野博志, 嬉野博志, 蒲池和晴, 蒲池和晴, 倉橋祐樹, 倉橋祐樹, et al. Overexpression of UCK2 in HTLV-1-infected cells in ATL leukemogenesis. 日本HTLV-1学会学術集会. 2022. 8th
  • Hiroshi Ureshino, Tatsuro Watanabe, Kaoru Tohyama, Seiji Okada, Hironori Harada, Toshikazu Ushijima, Shinya Kimura. A new hypomethylating agent, OR-2100, resists cytidine deaminase with oral absorbability and anti-leukemia effects. CANCER SCIENCE. 2021. 112. 674-674
  • Tatsuro Watanabe, Hiroshi Ureshino, Satoshi Yamashita, Toshikazu Ushijima, Seiji Okada, Eisaburo Sueoka, Shinya Kimura. DNA hypermethylation of THEMIS, a regulator of T-Cell Receptor signaling, in adult T-cell leukemia-lymphoma. CANCER SCIENCE. 2021. 112. 260-260
  • 渡邉達郎, 吉田奈央, 吉田奈央, 山本雄大, 嬉野博志, 嬉野博志, 蒲池和晴, 蒲池和晴, 倉橋祐樹, 倉橋祐樹, et al. メチオニン代謝を介したHTLV-1感染細胞のエピゲノム調節. 日本HTLV-1学会学術集会. 2021. 7th
  • 蒲池和晴, 蒲池和晴, 嬉野博志, 嬉野博志, 吉田奈央, 山本雄大, 倉橋祐樹, 渡邉達郎, 岡田誠治, 木村晋也, et al. Novel orally available hypomethylating agent OR-2100 impairs CML stem cell. 日本血液学会学術集会抄録(Web). 2021. 83rd
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Patents (11)：
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Books (1)：
  • RIの逆襲-アイソトープを活用した簡単・安全バイオ実験 (細胞工学別冊 実験プロトコールシリーズ)
    秀潤社 2007 ISBN:4879623628
Education (1)：
  • 1979 - 1985 Jichi Medical School School of Medicine
Professional career (1)：
  • 博士(医学) (自治医科大学)
Work history (12)：
  • 2019/04 - 現在 Joint Research Center for Human Retrovirus Infection, Kumamoto University Division of Hematopoiesis Professor
  • 2006/04 - 現在 Radioisotope Center Director
  • 2002/09 - 2019/03 Kumamoto University Center for AIDS Research Professor
  • 2000/04 - 2002/08 Chiba University Graduate School of Medicine Associate Professor
  • 1996/05 - 2000/03 Chiba University Division of Developmental Genetics, Center for Biomedical Science Assistant Professor
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Committee career (7)：
  • 2023/01 - 現在 Japanese Cancer Association councillor
  • 2017 - 現在 日本エイズ学会 評議員
  • 2016/04 - 現在 日本サイトメトリー学会 理事
  • 2009/10 - 現在 日本血液学会 評議員
  • 2008/04 - 現在 日本サイトメトリー学会 評議員
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Awards (5)：
  • 2010/11 - 日本白血病研究基金 一般研究賞
  • 2000/06 - ゐのはな同窓会 学術賞
  • 1999/11 - 持田記念医学薬学振興財団 研究奨励賞
  • 1993/04 - 日本血液学会 奨励賞
  • 1992/05 - 地域医療振興協会 地域保健医療研究奨励賞
Association Membership(s) (9)：
International Society for Experimental Hematology ,  The American Association of Immunologists ,  The American Society of Hematology ,  THE JAPANESE SOCIETY FOR AIDS RESEARCH ,  THE JAPANESE CANCER ASSOCIATION ,  THE JAPANESE SOCIETY OF INTERNAL MEDICINE ,  JAPAN CYTOMETRY SOCIETY ,  THE JAPANESE SOCIETY FOR IMMUNOLOGY ,  THE JAPANESE SOCIETY OF HEMATOLOGY
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