Research theme for competitive and other funds (18):
2022 - 2025 うつ病における脳内テロメア短縮のメカニズムー動物モデルによる検討
2021 - 2024 うつ病の海馬テロメア長短縮に対するmiRNA制御機構の解明
2019 - 2022 The role of the amygdala in depression
2016 - 2019 Elucidation of neural mechanisms underlying fear memory using DREADD
2018 - 2019 うつ病における内分泌異常および生体リズム異常の 解明
2017 - 2019 ストレス/うつ/自殺-負のスパイラルを結ぶ分子機構の解明
2015 - 2018 Epigenetic effects of early life stress on adult hippocampal neurogenesis
2016 - 2018 うつ病における海馬と扁桃体の統合的理解を目指して
2018 - 武田薬品工業
2017 - うつ病における脳内グルココルチコイド受容 体-FKBP5調節系の役割
2014 - 2016 自殺感受性遺伝子の中枢神経系における機能解析
2011 - 2014 Functional develpment of 5-HT/GABA neurons in the raphe nuclei - postnatal stress and epigenetics
2012 - 2014 SSRI の抗不安作用における扁桃体 5-HT 神経系の役割
2009 - 2011 不安と衝動性の脳内神経機構の研究
2008 - 2010 Effects of early postnatal stress on the development of 5-HT/GABA co-localized neuron in the raphe nuclei
2007 - 2008 A study of neural circuits underlying stress regulation at the critical period during brain development
2007 - 2008 扁桃体を中心とした不安の脳内神経回路の研究
2007 - 幼若期ストレスが成熟後の脳機能に及ぼす影響
Show all
Papers (88):
Toshiya Matsushima, Noriyuki Toji, Kazuhiro Wada, Hiroki Shikanai, Takeshi Izumi. Embryonic exposure to valproic acid and neonicotinoid deteriorates the developmental GABA switch and impairs long-term potentiation in the local circuit of intermediate medial mesopallium of chick telencephalon. bioRxiv. 2024
Naoya Suzuki, Sachiko Hiraide, Hiroki Shikanai, Takeru Isshiki, Taku Yamaguchi, Takeshi Izumi, Kenji Iizuka. Impaired monoamine neural system in the mPFC of SHRSP/Ezo as an animal model of attention-deficit/hyperactivity disorder. Journal of Pharmacological Sciences. 2024. 154. 2. 61-71
Toshiya Matsushima, Takeshi Izumi, Giorgio Vallortigara. The domestic chick as an animal model of autism spectrum disorder: building adaptive social perceptions through prenatally formed predispositions. Frontiers in Neuroscience. 2024. 18
Tsugumi Shindo, Hiroki Shikanai, Akane Watarai, Sachiko Hiraide, Kenji Iizuka, Takeshi Izumi. D-serine metabolism in the medial prefrontal cortex, but not the hippocampus, is involved in AD/HD-like behaviors in SHRSP/Ezo. European Journal of Pharmacology. 2022. 923. 174930-174930
Hiroki Shikanai, Kazuko Ikimura, Momoko Miura, Tsugumi Shindo, Akane Watarai, Takeshi Izumi. Separation and detection of D-/L-serine by conventional HPLC. MethodsX. 2022. 9. 101752-101752
YAMAGUCHI T, TSUJIMATSU A, KUMAMOTO H, IZUMI T, OHMURA Y, YOSHIDA T, YAMAMOTO T, YOSHIOKA M. Anxiolytic effects of yokukansan and serotonin 5-HT_<1A> receptors in rats. 日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology. 2013. 33. 2. 71-72
Shikanai Hiroki, Yoshida Takayuki, Konno Kohtarou, Yamasaki Miwako, Izumi Takeshi, Ohmura Yu, Shimamura Keiichi, Watanabe Masahiko, Yoshioka Mitsuhiro. Unique neural characteristics of GAD67-containing 5-HTergic neurons in the rat dorsal raphe nucleus. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 65P
鹿内 浩樹, 吉田 隆行, 今野 幸太郎, 山崎 美和子, 泉 剛, 大村 優, 渡邊 雅彦, 吉岡 充弘. Distinct neurochemical and functional properties of GAD67-containing 5-HT neurons in the rat dorsal raphe nucleus. 北海道醫學雜誌 = Acta medica Hokkaidonensia. 2012. 87. 6. 288-288