Waku Tsuyoshi

ワクツヨシ | Waku Tsuyoshi

Affiliation and department：
Job title： Associate Professor

Research field (2)： Molecular biology , Tumor biology

Research keywords (7)： cancer metabolism , Transcription , Protein degradation , Tumor development , Obesity , 脂質代謝 , 腫瘍免疫

Research theme for competitive and other funds (19)：

2023 - 2026 Physiological function of arginine signaling:macropinocytosisand tumor immune evasion
2023 - 2025 Nrf3誘導性ヘテロ-オートファジーを介したMHC-I分解によるがんの免疫逃避メカニズム解明
2022 - 2025 Obesity paradox of cancer immune response by a CNC-family transcriptiona factor NRF3
2020 - 2025 Elucidation of functional dopamine neuronal subsets
2023 - 2024 免疫逃避戦略を支える新規がん代謝リプログラミング機構の解明

Show all

Papers (39)：

Atsushi Hatanaka, Sota Nakada, Gen Matsumoto, Katsuya Satoh, Iori Aketa, Akira Watanabe, Tomoaki Hirakawa, Tadayuki Tsujita, Tsuyoshi Waku, Akira Kobayashi. The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis. Scientific reports. 2023. 13. 1. 14405-14405
Shuuhei Hirose, Tsuyoshi Waku, Misato Tani, Haruka Masuda, Keiko Endo, Sanae Ashitani, Iori Aketa, Hina Kitano, Sota Nakada, Ayaka Wada, et al. NRF3 activates mTORC1 arginine-dependently for cancer cell viability. iScience. 2023. 26. 2. 106045-106045
Tsuyoshi Waku, Sota Nakada, Haruka Masuda, Haruna Sumi, Ayaka Wada, Shuuhei Hirose, Iori Aketa, Akira Kobayashi. The CNC-family transcription factor Nrf3 coordinates the melanogenesis cascade through macropinocytosis and autophagy regulation. Cell Reports. 2023. 42. 1. 111906
Tsuyoshi Waku, Takuya Iwami, Haruka Masuda, Shuuhei Hirose, Iori Aketa, Akira Kobayashi. Nrf3 Functions Reversely as a Tumorigenic to an Antitumorigenic Transcription Factor in Obese Mice. The Tohoku Journal of Experimental Medicine. 2023. 259. 1. 1-8
Tsuyoshi Waku, Akira Kobayashi. Pathophysiological Potentials of NRF3-Regulated Transcriptional Axes in Protein and Lipid Homeostasis. International Journal of Molecular Sciences. 2021. 22. 23. 12686-12686

ｍore...

MISC (1)：

青野栞, 和久剛, 筆宝義隆, 小林聡. 大腸ガン細胞におけるNRF3遺伝子の発現誘導メカニズムの解明. 日本生化学会大会プログラム・講演要旨集. 2018. 91回. [1T14a-03(1P

Patents (3)：

Books (1)：

Lectures and oral presentations (29)：

NRF1 and NRF3 complementarily maintain basal proteasome activity in cancer cells through CPEB3-Mediated translational repression
(2021)
転写因子NRF3はがん細胞内のセリン代謝を制御する
(先端モデル動物プラットフォーム若手支援技術講習会 2020)
NRF3-POMP経路を介したユビキチン非依存的なタンパク質分解の誘導によるがん増悪メカニズム
(第14回日本臨床ストレス応答学会大会 2019)
NRF3 acts as a tumorigenic transcription factor for the assembly of a ubiquitin-independent 20S proteasome
(2019)
NRF3 (NFE2L3) contributes to colorectal cancer development through 20S proteasome assembly and the ubiquitinindependent proteolysis
(The Environmental Response V /17th JBS Biofrontier Symposium 2019)

ｍore...

Education (3)：

2006 - 2009 大阪大学大学院理学研究科博士後期課程
2004 - 2006 Kobe University
2000 - 2004 Kindai University Faculty of Biology-Oriented Science and Technology Department of Genetic Engineering

Professional career (1)：

Work history (5)：

2021/04 - 現在 Doshisha University Faculty of Life and Medical Sciences
2015/04 - 2021/03 Doshisha University Faculty of Life and Medical Sciences
2012/04 - 2015/03 東京大学大学院薬学研究科日本学術振興会特別研究員
2011/04 - 2012/03 University of Tsukuba Life Science Center of Tsukuba Advanced Research Alliance (TARA)
2009/04 - 2011/03 Osaka University Institute for Protein Research

Association Membership(s) (3)：

THE JAPANESE CANCER ASSOCIATION , THE JAPANESE BIOCHEMICAL SOCIETY , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page