Research theme for competitive and other funds (21)：
2022 - 2025 オルガノイドを用いた脂肪由来幹細胞からの超高機能肝細胞様細胞の確立
2021 - 2025 Experimental research on the biological action of nanosecond pulsed electric fields and its evolving to medical technology
2019 - 2022 A chemical genetic approach to exploring novel therapeutics targeting the integrated stress response
2018 - 2021 Development of integrated treatment for impaired liver regeneration on non-alcoholic steatohepatitis
2017 - 2020 Rapid early diagnoses for diabetes progression stage and the complications risk by novel circulating miRNAs, towards the therapeutic applications
2016 - 2019 Development of potential anti-sarcopenia agents targeting the integrated stress response
2016 - 2018 Role of ER stress-induced ncRNA in renal cancer pathogenesis
2015 - 2018 Immune response mediated by hepatic stellate cells with endoplasmic reticulum stress in liver transplantation.
2014 - 2017 The study of endoplasmic reticulum stress pathway in mechanical stress-loaded chondrocyte
2014 - 2017 A study about a novel influence and elucidation of Bevacizumab, molecular targeted drug, on liver regeneration after massive hepatectomy
2014 - 2017 Development of multidisciplinary therapy for aged liver insufficiency based on the mechanism of hepatic stellate cell dysfunction.
2013 - 2017 Physiological and pathological role of the endoplasmic reticulum stress transducer protein ATF6beta
2014 - 2016 Therapeutic development for Inclusion Body Myositis targeting endoplasmic reticulum stress response
2013 - 2015 The role of unfolded protein response on hepatic stellate cell in old liver ischemia reperfusion injury and liver regeneration
2012 - 2015 Genetic identification and functional analysis in Japanese families with a short stature
2011 - 2014 Development of multidisciplinary therapy based on mechanism of liver insufficiency in a use of Aged partial graft after liver transplantation.
2011 - 2013 Functional analysis of endoplasmic reticulum stress in the progression of cartilage degeneration
2011 - 2012 Role of endoplasmic reticulum stress response in lifestyle diseases caused by unhealthy diet
2010 - 2012 Glucose and lipid metabolism regulated by the endoplasmic reticulum signaling
2008 - 2010 Analysis of molecular mechanism of sensing endoplasmic reticulum stress and effect of failing in the endoplasmic reticulum stress response
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Papers (74)：
Jirapat Namkaew, Jun Zhang, Norio Yamakawa, Yoshimasa Hamada, Kazue Tsugawa, Miho Oyadomari, Masato Miyake, Toyomasa Katagiri, Seiichi Oyadomari. Repositioning of mifepristone as an integrated stress response activator to potentiate cisplatin efficacy in non-small cell lung cancer. Cancer letters. 2024. 582. 216509-216509
Mitsuaki Sobajima, Masato Miyake, Yoshimasa Hamada, Kazue Tsugawa, Miho Oyadomari, Ryota Inoue, Jun Shirakawa, Hiroshi Arima, Seiichi Oyadomari. Corrigendum to "The multifaceted role of ATF4 in regulating glucose-stimulated insulin secretion" [Biochem. Biophys. Res. Commun. 611 (2022) 165-171]. Biochemical and biophysical research communications. 2024. 692. 149412-149412
Takashi Tanaka, Dinh Thi Nguyen, Nichakarn Kwankaew, Megumi Sumizono, Reika Shinoda, Hiroshi Ishii, Mika Takarada-Iemata, Tsuyoshi Hattori, Seiichi Oyadomari, Nobuo Kato, et al. ATF6β Deficiency Elicits Anxiety-like Behavior and Hyperactivity Under Stress Conditions. Neurochemical Research. 2023
Qiqiao Du, Jieyu Wu, Carina Fischer, Takahiro Seki, Xu Jing, Juan Gao, Xingkang He, Kayoko Hosaka, Le Tong, Akihiro Yasue, et al. Generation of mega brown adipose tissue in adults by controlling brown adipocyte differentiation in vivo. Proceedings of the National Academy of Sciences of the United States of America. 2022. 119. 40. e2203307119
Mitsuaki Sobajima, Masato Miyake, Yoshimasa Hamada, Kazue Tsugawa, Miho Oyadomari, Ryota Inoue, Jun Shirakawa, Hiroshi Arima, Seiichi Oyadomari. The multifaceted role of ATF4 in regulating glucose-stimulated insulin secretion. Biochemical and biophysical research communications. 2022. 611. 165-171
Keisuke Kitakaze, Shusuke Taniuchi, Eri Kawano, Yoshimasa Hamada, Masato Miyake, Miho Oyadomari, Hirotatsu Kojima, Hidetaka Kosako, Tomoko Kuribara, Suguru Yoshida, et al. Identification of a chemical chaperone for mitigating protein aggregation and proteotoxicity during endoplasmic reticulum stress. The FASEB Journal. 2021. 35. S1
Keisuke Kitakaze, Kiyoe Kurahashi, Masato Miyake, Yoshimasa Hamada, Miho Oyadomari, Seiichi Oyadomari. Targeted Deletion of ATF4 in beta Cells Leads to the Vulnerability and Dedifferentiation during ER Stress. DIABETES. 2018. 67. Supplement 1
