Shigeru Miyagawa

ミヤガワシゲル | Shigeru Miyagawa

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://kaken.nii.ac.jp/d/r/70544237.ja.html

Research field (2)： Respiratory surgery , Cardiovascular surgery

Research keywords (30)： iPS細胞 , 心不全 , 再生医療 , 再生医学 , 人工心臓 , 幹細胞 , 心不全薬 , トランスレーショナルリサーチ , 機械的刺激 , 心筋分化 , 移植・再生医療 , 左室形成デバイス , 細胞・組織 , 心筋梗塞 , 心筋再生 , 細胞移植 , 細胞シート , Muse細胞 , 心筋細胞 , micro RNA , アディポネクチン , 心房細動 , Drug delivery system , シミュレーション , 難治性疾患 , 血流評価 , 拡張能 , プロスタグランジン製剤 , 腹部大動脈瘤 , 拒絶反応

Research theme for competitive and other funds (35)：

2024 - 2027 Study on the use of adipocyte-derived stem cells, exosome, to inhibit the progression of aortic aneurysms
2022 - 2025 脂肪細胞由来幹細胞exosomeを用いた新規cell-free心筋再生療法の開発
2022 - 2025 Novel regenerative therapy for liver failure with skeletal myoblast cell sheet transplantation
2022 - 2025 制御性T細胞を用いた移植免疫制御方法の開発
2022 - 2024 複数組織の異種界面接合の科学的理解と運動器モデルの生体外構築

2021 - 2024 Effects of nutrition, aging, and stem cell against inflammation on high-risk heart disease, and evaluation of tissue regeneration ability.

2021 - 2024 心筋再生療法のメカニズム究明のための心筋ミトコンドリア機能のイメージング

2015 - 2019 Metabolic profiling of reverse remodeling and cardiac recovery in end-stage congestive hart failure

2015 - 2018 Overcoming ischemic cardiomyopathy by angiogenic drugs

2015 - 2018 The impact of transplantation of cardiomyocyte sheet derived from MHC homozygous induced pluripotent stem cells

2015 - 2018 Degenerative therapy for heart failure using skeletal muscle cell-extracellular matrix interaction.

2015 - 2018 Study of drug discovery using cardiomyocytes derived from iPS cells in cardiovascular diseases

2015 - 2017 iPSC derived three dimensional cardiac tissue having circulatory system

2014 - 2017 Development of immune tolerance method for clinical application of allogeneic iPS cells

2014 - 2017 Engineeing of the heart tissues using decellularized extracellular matrix - Development of basic technology to construct three-dimensional organ-like tissues

2013 - 2015 In vivo and vitro noble differentiation of induced pluripotent stem cell derived cardiomyocytes

2013 - 2015 Investigation for immune tolerace of allogeneic induced pluripotent stem cell-derived cardiomyocyte

2012 - 2015 The development of novel therapeutic strategy for pediatric heart failure patients using ventricular assist devices and cardiac regnerative therapy.

2012 - 2015 Degenerative therapy for heart failure using autologous myocardial fibroblast.

2012 - 2015 The development of surgical treatment targeting myocardial stiffness in damaged myocardium

2012 - 2014 Developing microRNA research in cardiac failure

2010 - 2013 アディポネクチン産生細胞シートを用いた新規大動脈瘤治療に関する研究

2011 - 2012 Development of new treatment of heart failure using induced pluripotent stem cells-derived cardiomyocytes

2011 - 2012 Analysis of relationship between microRNA expression and atrial fibrillation for development of new treatment

2011 - 2012 Development of cardiac regenerative medicine using a novel human somatic stem cell (Muse cell)

2010 - 2012 The development of novel therapy combined LVAD and regenerative medicine for severe heart failure patients

2010 - 2011 Development and the clinical application of the caqrdiovascular operation support program applied hydrodynamics simulation

2010 - 2011 Development of Targeted Adiponectin Delivery System by Using Induced Adipocyte Cell-sheet

2009 - 2011 Development of new stent graft system using whole aortic navigation

2009 - 2011 Developing a novel regenerative treatment for cardiac failure by using iPS cell-derived self-cardiac tissue

2009 - 2011 Development of the new cell-free device for sever heart failure by restructuring of artificial stem cell niche using extracellular matrixes and stem cell recruitment/differentiation factors

2009 - 2011 Development of the new carrier device for sever heart failure using apoptotic cell-mimetic liposome

2007 - 2008 Therapeutic effect of growth factor enhancement of cardiacregeneration on cardiac remodeling in infarcted rat hearts

2007 - 2008 Development of novel scaffold for cardiac regeneration

2006 - 2008 Identification and therapeuticeffect of growth factor inducingmyoblast sheet transplantation in infarcted rat hearts

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Papers (529)：

Kazuma Handa, Masashi Kawamura, Daisuke Yoshioka, Shunsuke Saito, Takuji Kawamura, Ai Kawamura, Yusuke Misumi, Masaki Taira, Kazuo Shimamura, Sho Komukai, et al. Impact of the Aortomitral Positional Anatomy on Atrioventricular Conduction Disorder Following Mitral Valve Surgery. Journal of the American Heart Association. 2024. e035826
Shunsuke Saito, Daisuke Yoshioka, Takuji Kawamura, Ai Kawamura, Yusuke Misumi, Yasuhiro Akazawa, Fusako Sera, Kaori Kubota, Takashi Yamauchi, Yasushi Sakata, et al. The foremost and greatest barrier to end-stage heart failure treatment: the impact of caregiver shortage. Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs. 2024
Kizuku Yamashita, Koichi Maeda, Kyongsun Pak, Kazuo Shimamura, Ai Kawamura, Isamu Mizote, Masaki Taira, Daisuke Yoshioka, Shigeru Miyagawa. A risk model of mortality rate in dialysis patients following transcatheter aortic valve replacement. Journal of cardiology. 2024
Shunsuke Saito, Shuji Miyagawa, Takuji Kawamura, Daisuke Yoshioka, Masashi Kawamura, Ai Kawamura, Yusuke Misumi, Takura Taguchi, Takashi Yamauchi, Shigeru Miyagawa. How should cardiac xenotransplantation be initiated in Japan?. Surgery today. 2024. 54. 8. 829-838
Kazuki Tanimoto, Takashi Kido, Masaki Taira, Takuji Watanabe, Jun Narita, Hidekazu Ishida, Ryo Ishii, Takayoshi Ueno, Shigeru Miyagawa. A case of truncus arteriosus with severe heart failure and pulmonary stenosis: bridge to transplant candidacy with surgical correction and a ventricular-assist device. Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs. 2024

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MISC (536)：

川北紘輝, 石川慶, 森垣大樹, 峰松佑輔, 楠本繁崇, 吉田靖, 小山有紀子, 河村拓史, 吉岡大輔, 宮川繁, et al. 中長期使用可能なECMO回路選定基準策定と臨床運用での検討. 日本集中治療医学会学術集会(Web). 2024. 51st
石川慶, 峰松佑輔, 川北紘輝, 森垣大樹, 楠本繁崇, 吉田靖, 河村拓史, 吉岡大輔, 宮川繁, 小山有紀子, et al. 重症心不全に対するIMPELLA5.5の使用経験. 日本集中治療医学会学術集会(Web). 2024. 51st
松井翼, 上村葉, 植村壽公, 植村壽公, 笹井雅夫, 寒川延子, 寒川延子, 宮川繁, 紀ノ岡正博, 森田健一, et al. 3次元回転浮遊培養と物理的な細胞分散技術によるiPS細胞由来心筋細胞塊の製造の試み. 日本再生医療学会総会(Web). 2024. 23rd
植村寿公, 植村寿公, 橋田礼博, 中里太郎, LIU Li, 宮川繁, 澤芳樹, 紀ノ岡正博. 回転浮遊培養によるヒトiPS細胞由来心筋組織の成熟化メカニズムの解明. 日本再生医療学会総会(Web). 2024. 23rd
宇田大介, 石川慶, 松本猛志, 吉田幸太郎, 中村有希, 峰松佑輔, 楠本繁崇, 河村拓史, 吉岡大輔, 吉田靖, et al. 大腿動静脈創部感染症を併発した重症心不全患者における右鎖骨下動静脈を用いたV-A ECMOの一例. 日本経皮的心肺補助研究会プログラム・抄録集(Web). 2023. 33rd

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Work history (7)：

2021/07 - 現在 Osaka University Graduate School of Medicine Department of Cardiovascular Surgery Professor
2018/04 - 2021/06 Osaka University
2016/07 - 2018/03 Osaka University
2014/04 - 2016/06 Osaka University
2013/04 - 2014/03 Osaka University Graduate School of Medicine

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