Rchr
J-GLOBAL ID:201501021011924746   Update date: Jun. 23, 2021

Ota Akinobu

オオタ アキノブ | Ota Akinobu
Affiliation and department:
Research field  (3): Hematology and oncology ,  Pathobiochemistry ,  Genomics
Research keywords  (6): Innate Immunity ,  ゲノム編集 ,  多発性骨髄腫 ,  がん ,  ゲノム異常 ,  トランスクリプトーム
Research theme for competitive and other funds  (9):
  • 2021 - 2024 PBKを標的とする抗骨髄腫薬導出に向けた創薬プラットフォームの構築と分子機能解析
  • 2019 - 2022 骨格筋再生による疼痛性瘢痕治療法の研究:間葉系幹細胞の選択と細胞外環境の解析
  • 2019 - 2022 胸膜中皮腫の予後改善を目指した診断マーカーと阻害化合物の探索
  • 2019 - 2022 ゲノム編集によるFLT3変異改変ヒト白血病細胞の作製と新規治療法の探索
  • 2018 - 2021 癌特異的代謝を介し増悪化に寄与するGPCR OR7C1の作用機序解明と治療応用
Show all
Papers (54):
  • Sivasundaram Karnan, Ichiro Hanamura, Akinobu Ota, Souichi Takasugi, Ayano Nakamura, Miyuki Takahashi, Kaori Uchino, Satsuki Murakami, Md Wahiduzzaman, Lam Quang Vu, et al. CD52 is a novel target for the treatment of FLT3-ITD-mutated myeloid leukemia. Cell death discovery. 2021. 7. 1. 121-121
  • Yusuke Azami, Naohiro Tsuyama, Yu Abe, Misaki Sugai-Takahashi, Ken-Ichi Kudo, Akinobu Ota, Karnan Sivasundaram, Moe Muramatsu, Tomonari Shigemura, Megumi Sasatani, et al. Chromosomal translocation t(11;14) and p53 deletion induced by the CRISPR/Cas9 system in normal B cell-derived iPS cells. Scientific reports. 2021. 11. 1. 5216-5216
  • Aya Nagano-Matsuo, Satoshi Inoue, Akira Koshino, Akinobu Ota, Kenju Nakao, Masayuki Komura, Hiroyuki Kato, Aya Naiki-Ito, Kawori Watanabe, Yuko Nagayasu, et al. PBK expression predicts favorable survival in colorectal cancer patients. Virchows Archiv : an international journal of pathology. 2021
  • Sivasundaram Karnan, Akinobu Ota, Hideki Murakami, Md Lutfur Rahman, Muhammad Nazmul Hasan, Md Wahiduzzaman, Ichiro Hanamura, Lam Quang Vu, Akihito Inoko, Toshinori Hyodo, et al. Identification of CD24 as a potential diagnostic and therapeutic target for malignant pleural mesothelioma. Cell Death Discovery. 2020. 6. 1
  • Akinobu Ota, Ichiro Hanamura, Sivasundaram Karnan, Shingo Inaguma, Norio Takei, Vu Quang Lam, Shohei Mizuno, Jo Kanasugi, Md Wahiduzzaman, Md Lutfur Rahman, et al. Novel Interleukin-6 Inducible Gene PDZ-Binding Kinase Promotes Tumor Growth of Multiple Myeloma Cells. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2020. 40. 8. 389-405
more...
MISC (69):
Books (6):
  • CRISPR-Cas-mediated genome editing:Novel technology to clarify molecular mechanism contributing to malignant phenotype of multiple myeloma
    2020
  • Role of PDZ binding kinase in tumorigenesis of multiple myeloma
    2019
  • CRISPR/Cas9-mediated Genome Editing: novel technology to clarify molecular mechanism contributing to malignant phenotype of multiple myeloma
    2019
  • Involvement of PDZ binding kinase in molecular pathogenesis of multiple myeloma
    BIO Clinica 2019
  • Arsenic-Based Anticancer-Combined Therapy: Novel Mechanism Inducing Apoptosis of Cancer Cells
    IntechOpen 2018
more...
Education (2):
  • 2006 - 2010 Sapporo Medical University
  • 1998 - 2002 Nagoya University Health Sciences
Professional career (1):
  • 医学博士 (札幌医科大学大学院医学研究科)
Work history (5):
  • 2017/04 - 現在 Kinjo Gakuin University Lecturer (part-time)
  • 2014/04 - 現在 Aichi Medical University School of Medicine Department of Biochemistry Associate Professor
  • 2020/08 - 2021/01 University of Washington Department of Immunology Visiting Assistant Professor
  • 2011/01 - 2013/03 Aichi Medical University School of Medicine Department of Biochemistry Assistant Professor
  • 2002/04 - 2010/12 Immuno-Biological Laboratories, Co. Ltd.
Awards (1):
  • 2018/05 - 日本骨髄腫学会 平成30年度日本骨髄腫学会奨励賞
Association Membership(s) (4):
Japanese Society of Myeloma ,  THE JAPANESE BIOCHEMICAL SOCIETY ,  THE JAPANESE CANCER ASSOCIATION ,  THE JAPANESE SOCIETY OF HEMATOLOGY
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