Rchr
J-GLOBAL ID：201501048676713504
Update date: Nov. 19, 2024
Ohno Seiko
オオノ セイコ | Ohno Seiko
Affiliation and department：
Job title：
Director
Research field (1)：
Cardiology
Research keywords (3)：
電気生理学
, 循環器病学
, 遺伝学
Research theme for competitive and other funds (19)：
- 2021 - 2026 臨床予後予測に向けたiPS細胞由来心筋症モデルによる特発性拡張型心筋症の病態解明
- 2022 - 2025 バイオインフォマティクスを用いた非コードDNA解析による若年突然死の発症機序解明
- 2022 - 2025 遺伝的背景が不明なカテコラミン誘発多型性心室頻拍患者における遺伝子構造多型の検索
- 2021 - 2024 The elucidation of complicated genetic backgrounds and pathogenicity in patients with inherited primary arrhythmia syndromes caused by unknown etiology
- 2021 - 2024 Development of a non-invasive early diagnosis method for fetal long QT syndrome
- 2021 - 2024 Elucidation of the pathology in ARVC caused by Japanese-specific DSG2 mutations using knock-in mice models: searching for the therapeutic targets
- 2019 - 2022 Elucidation of pathology of inherited cardiac disease caused by mutations in ryanodine receptor gene
- 2019 - 2022 Whole-genome sequencing analysis using epigenetics databases to elucidate novel mechanisms of inherited arrhythmia syndromes
- 2018 - 2022 Subclinical atherosclerosis and brain atrophy in general Japanese women : the second phase survey
- 2018 - 2021 Elucidation of pathogenesis and clinical characteristics, establishment of the therapy in patients with LQTS caused by calcium related gene variants
- 2018 - 2021 Investigation of relationship between inherited arrhythmias and epigenetics
- 2017 - 2020 The risk stratification of drug-induced long QT syndrome upon the underlying genetics
- 2017 - 2019 Elucidation of mechanism of cardiac calcium channel (CaV1.2) abnormality in long QT syndrome
- 2015 - 2018 Subclinical atherosclerosis and brain atrophy in the general Japanese women
- 2015 - 2018 Gut microbiota and sublinical atherosclerosis in general population
- 2015 - 2018 Multilateral Research on the Mechanisms of Inherited Arrhythmias
- 2015 - 2018 Effective diagnosis and establishment of the therapy for catecholaminergic polymorphic ventricular tachycardia
- 2015 - 2017 Mechanism of Inherited Arrhythmia Syndrome with SCN10A mutation
- 2012 - 2015 Mechanism of arrhythmo-genesis by exercise stress in long QT syndrome patients
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Papers (291)：
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Keiko Shimamoto, Naokata Sumitomo, Taisuke Nabeshima, Seiko Ohno, Wataru Shimizu, Kengo Kusano, Takeshi Aiba. Novel Compound Heterozygous Variants in Trans-2,3-Enoyl-Coenzyme A Reductase-Like Gene Associated With Catecholaminergic Polymorphic Ventricular Tachycardia. JACC. Case reports. 2024. 29. 11. 102364-102364
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Taisuke Ishikawa, Tatsuo Masuda, Tsuyoshi Hachiya, Christian Dina, Floriane Simonet, Yuki Nagata, Michael W T Tanck, Kyuto Sonehara, Charlotte Glinge, Rafik Tadros, et al. Brugada syndrome in Japan and Europe: a genome-wide association study reveals shared genetic architecture and new risk loci. European Heart Journal. 2024
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Eitaro Kume, Masaru Yamakawa, Chisato Miyakoshi, Chie Aota, Satoru Tsuruta, Minoru Horie, Seiko Ohno. Molecular Autopsy With Banked Cord Blood Reveals Brugada Syndrome in Past Sudden Death Case. Pediatrics. 2024. 153. 6
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Makiyama Takeru, Gao Jingshan, Yamamoto Yuta, Kobayashi Takuya, Takanori Aizawa, Huang Hai, Kasahiwa Asami, Imamura Tomohiko, Aoki Hisaaki, Kato Koichi, et al. 心疾患の発症機構解明と新たな治療戦略 iPS細胞を用いたカルモジュリン遺伝子異常による致死性不整脈疾患の病態解明(Elucidation of the pathogenesis of heart diseases and development of new therapeutic strategies Modeling calmodulin-related life-threatening arrhythmias using iPS cells). The Journal of Physiological Sciences. 2024. 74. Suppl.2. 99-99
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Manon Baudic, Hiroshige Murata, Fernanda M. Bosada, Uirá Souto Melo, Takanori Aizawa, Pierre Lindenbaum, Lieve E. van der Maarel, Amaury Guedon, Estelle Baron, Enora Fremy, et al. TAD boundary deletion causes PITX2-related cardiac electrical and structural defects. Nature Communications. 2024. 15. 1
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MISC (253)：
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三谷孟司, 三谷孟司, 糀谷泰彦, 糀谷泰彦, 岡本有司, 相澤卓範, 牧山武, 牧山武, 大野聖子, 堀江稔, et al. Development of Deep-Generative Models with Fine-tuning Techniques for Genetic Risk Prediction and Prognosis Stratification of Hereditary Arrhythmic Disease. 日本循環器学会学術集会(Web). 2024. 88th
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KOHJITANI Hirohiko, KOHJITANI Hirohiko, MITANI Takeshi, OKAMOTO Yuji, AIZAWA Takanori, MAKIYAMA Takeru, MAKIYAMA Takeru, KASHIWA Asami, IMAMURA Tomohiko, OHNO Seiko, et al. Development of Precise Genetic Prognostic Model for Hereditary Arrhythmia Disease Using Machine Learning. 日本不整脈心電学会学術大会プログラム・抄録集(Web). 2022. 68th
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KASHIWA Asami, MAKIYAMA Takeru, WADA Yuko, OZAWA Junichi, AIZAWA Takanori, IMAMURA Tomohiko, HUANG Hai, GAO Jingshan, KOHJITANI Hirohiko, OHNO Seiko, et al. Arrhythmic Risk is NOT Homogeneous in C-Terminal KCNQ1 Variants of Long QT Syndrome. 日本不整脈心電学会学術大会プログラム・抄録集(Web). 2022. 68th
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GAO Jingshan, MAKIYAMA Takeru, YAMAMOTO Yuta, KOBAYASHI Takuya, AOKI Hisaaki, MAURISSEN L Thomas, KASHIWA Asami, IMAMURA Tomohiko, AIZAWA Takanori, HUANG Hai, et al. Novel CPVT-Associated Calmodulin Mutation Activating RyR2 Channels Causes Robust Arrhythmogenicity in iPS Cell Model. 日本不整脈心電学会学術大会プログラム・抄録集(Web). 2022. 68th
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IMAMURA Tomohiko, MAKIYAMA Takeru, OZAWA Junichi, HUANG Hai, AIZAWA Takanori, GAO Jingshan, KASHIWA Asami, KOHJITANI Hirohiko, KATO Koichi, AOKI Hisaaki, et al. Clinical Characteristics and Risk Stratification in Pediatric Brugada Syndrome. 日本不整脈心電学会学術大会プログラム・抄録集(Web). 2022. 68th
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Education (2)：
- 2002 - 2006 京都大学大学院 医学研究科 循環器内科学
- 1991 - 1997 Tohoku University Faculty of Medicine School of Medicine
Professional career (1)：
Work history (6)：
Awards (5)：
- 2017 - 滋賀医科大学 女性研究者賞
- 2014 - 井村臨床研究奨励賞
- 2011 - 4th Asia Pacific Heart Rhythm Society Scientific Session Young Investigator Award
- 2009 - Cardio Rhythm 2009 Hong Kong,Young Investigator Award
- 2009 - 第14回日本心電学会学術奨励賞
Association Membership(s) (6)：
日本小児心電学会
, 日本不整脈心電学会
, 日本小児循環器学会
, 日本人類遺伝学会
, 日本循環器学会
, 日本内科学会
