Rchr
J-GLOBAL ID：201501057175473405   Update date: Apr. 29, 2025

Saio Tomohide

サイオ トモヒデ | Saio Tomohide
Affiliation and department：
The University of Tokushima

About The University of Tokushima


Job title： Professor
Homepage URL  (1)： https://saio-lab.jp
Research field  (2)： Molecular biology ,  Structural biochemistry
Research keywords  (6)： Protein folding ,  molecular chaperone ,  Protein quality control ,  structure ,  protein ,  NMR
Research theme for competitive and other funds  (21)：
  • 2023 - 2028 Molecular dissection of plant specialized metabolism machineries
  • 2023 - 2026 Stratification of Protein Aggregation States based on Pattern Recognition for Screening Factors Controlling Phase Separation
  • 2022 - 2025 Mechanism of chaperone activity modulation through promiscuous recognitions
  • 2021 - 2024 Unraveling the mechanism of kinetic regulation in biomolecular folding
  • 2021 - 2024 Organization of kinetics-driven supramolecular chemistry
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Papers (56)：
  • Na Young Park, Yunseok Heo, Ji Won Yang, Je Min Yoo, Hye Ji Jang, Ju Hee Jo, Su Jeong Park, Yuxi Lin, Joonhyeok Choi, Hyeonjin Jeon, et al. Graphene Quantum Dots Attenuate TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis. ACS nano. 2025
  • Soichiro Kawagoe, Motonori Matsusaki, Takuya Mabuchi, Yuto Ogasawara, Kazunori Watanabe, Koichiro Ishimori, Tomohide Saio. Mechanistic Insights Into Oxidative Response of Heat Shock Factor 1 Condensates. JACS Au. 2025
  • Shinichi Sato, Shogo Miyano, Keita Nakane, Zhengyi Liu, Munehiro Kumashiro, Tomohide Saio, Yuya Tanaka, Akira Shigenaga, Chizu Fujimura, Eri Koyanagi, et al. Tyrosine bioconjugation using stably preparable urazole radicals. Tetrahedron Chem. 2024. 12. 100111-100111
  • Young-Ho Lee, Tomohide Saio, Mai Watabe, Motonori Matsusaki, Shingo Kanemura, Yuxi Lin, Taro Mannen, Tsubura Kuramochi, Katsuya Iuchi, Michiko Tajiri, et al. Ca2+-driven PDIA6 phase separation to ensure proinsulin quality control. 2024
  • Koki Suzuki, Ryoya Nojiri, Motonori Matsusaki, Takuya Mabuchi, Shingo Kanemura, Kotone Ishii, Hiroyuki Kumeta, Masaki Okumura, Tomohide Saio, Takahiro Muraoka. Redox-active chemical chaperones exhibiting promiscuous binding promote oxidative protein folding under condensed sub-millimolar conditions. Chemical Science. 2024. 15. 32. 12676-12685
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MISC (70)：
  • 藤原圭梧, 中曽根祐介, 中岡育也, 大田帆香, 川越聡一郎, 石森浩一郎, 斎尾智英, 寺嶋正秀. Crowding effects on light-induced folding dynamics. 日本化学会春季年会講演予稿集(Web). 2024. 104th
  • 吉村早織, 吉村早織, 吉村早織, 島田龍輝, 菊池浩二, 川越聡一郎, 阿部洋典, 飯阪早希絵, 藤村幸代子, 安永桂一郎, et al. 雄第一減数分裂前期のパキテン期進行に必須の役割を担うHSF5. 日本生殖医学会雑誌. 2024. 69. 4
  • 川越聡一郎, 久米田博之, 齋尾智英. Heat shock factor-1のストレス応答性液-液相分離の構造基盤. 日本蛋白質科学会年会(Web). 2024. 24th
  • 武井梓穂, 宇賀神魁, 中迫純希, 松尾友樹, 神田諒, 川越聡一郎, 齋尾智英, 松田正, 前仲勝実, 姚閔, et al. 乳がん特異的キナーゼとアダプター蛋白質が形成する分子集合と酵素活性の相関を検証する. 日本蛋白質科学会年会(Web). 2024. 24th
  • ZHU Haojie, 川越聡一郎, 久米田博之, 石森浩一郎, 齋尾智英. Structural study on a chaperone complex for protein unwinding. Abstracts. Annual Meeting of the NMR Society of Japan. 2023. 62nd (CD-ROM)
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Books (2)：
  • Structural Study of Proteins by Paramagnetic Lanthanide Probe Methods
    Springer 2017
  • NMR Structural Biology Using Paramagnetic Lanthanide Probe
    Springer 2016
Lectures and oral presentations  (54)：
  • シャペロンから解き明かすタンパク質フォールディングと集合の制御メカニズム
    (日本学術振興会・産学協力委員会 R022 量子構造生物学委員会 第11回 研究会 2023)
  • 生体分子の弱い相互作用をNMRで可視化する
    (第6回「大学発ベンチャー創出研究会」 2023)
  • Integrative Structural Study on a Multidomain Protein Enzyme Utilizing Paramagnetic Lanthanide Ion
    (2023 Asia-Pacific NMR Symposium 2023)
  • Structural and kinetic views of regulators for protein folding and assembly
    (International Symposium on Protein Folding, Aggregation, Misfolding Disease, and Disease Crosstalk 2023)
  • Visualizing conformational changes of a multidomain protein enzyme using paramagnetic probes
    (International Society of Magnetic Resonance (ISMAR) 2023 conference 2023)
ｍore...
Education (3)：
  • 2008 - 2011 Hokkaido University Graduate School of Life Science Ph.D. course
  • 2006 - 2008 Hokkaido University Graduate School of Life Science Master course
  • 2002 - 2006 Hokkaido University Faculty of Pharmaceutical Sciences
Professional career (1)：
  • 博士(生命科学) (北海道大学)
Work history (9)：
  • 2020/09 - 現在 The University of Tokushima Institute of Advanced Medical Sciences Professor
  • 2023/08 - 2026/03 Institute of Science Tokyo Medical Research Institute
  • 2023/04 - 2026/03 東北大学客員教授
  • 2021/08 - 2026/03 Nara Medical University
  • 2023/04 - 2024/03 京都大学客員教授
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Committee career (14)：
  • 2024/04 - 現在 The Journal of Medical Investigation Associate Editor
  • 2018 - 現在 Journal of Korean Magnetic Resonance Society Editorial Board
  • 2023/06 - 2027/06 日本蛋白質科学会 執行役員
  • 2023/04 - 2027/03 日本生物物理学会 代議員
  • 2021/04 - 2027/03 日本核磁気共鳴学会 評議員
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Awards (8)：
  • 2024/12 - せりか基金賞3位受賞
  • 2024/11 - 日本核磁気共鳴学会 進歩賞
  • 2021/11 - 公益財団法人アステラス病態代謝研究会 最優秀理事長賞
  • 2018/11 - The Chemical Society of Japan Research Incentive Award Structural basis for proteostasis regulated by molecular chaperones
  • 2018/11 - 日本化学会北海道支部 日本化学会北海道支部研究奨励賞 細胞内恒常性維持を担うシャペロンの動的構造基盤と制御
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Association Membership(s) (5)：
THE CHEMICAL SOCIETY OF JAPAN ,  THE JAPANESE BIOCHEMICAL SOCIETY ,  PROTEIN SCIENCE SOCIETY OF JAPAN ,  THE NUCLEAR MAGNETIC RESONANCE SOCIETY OF JAPAN ,  日本生物物理学会
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