Rchr
J-GLOBAL ID:201501057175473405   Update date: Sep. 02, 2021

Saio Tomohide

サイオ トモヒデ | Saio Tomohide
Affiliation and department:
Homepage URL  (2): https://www.fujii.tokushima-u.ac.jp/mls/http://www.iams.tokushima-u.ac.jp/specialty/
Research field  (2): Molecular biology ,  Structural biochemistry
Research keywords  (6): Protein folding ,  molecular chaperone ,  Protein quality control ,  structure ,  protein ,  NMR
Research theme for competitive and other funds  (16):
  • 2020 - 2023 Structural basis for recognition and regulation of protein folding intermediate by molecular chaperones in the endoplasmic reticulum
  • 2020 - 2023 Regulatory mechanism of biological phase separation
  • 2018 - 2023 新世代中性子構造生物学の開拓
  • 2019 - 2022 半特異的認識を介したシャペロンネットワークの構造基盤
  • 2019 - 2021 相分離を介したシグナル伝達制御の構造基盤
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Papers (34):
  • Masahiro Mimura, Shunsuke Tomita, Yoichi Shinkai, Takuya Hosokai, Hiroyuki Kumeta, Tomohide Saio, Kentaro Shiraki, Ryoji Kurita. Quadruplex Folding Promotes the Condensation of Linker Histones and DNAs via Liquid-Liquid Phase Separation. Journal of the American Chemical Society. 2021. 143. 26. 9849-9857
  • Tomohide Saio, Soya Hiramatsu, Mizue Asada, Hiroshi Nakagawa, Kazumi Shimizu, Hiroyuki Kumeta, Toshikazu Nakamura, Koichiro Ishimori. Conformational ensemble of a multidomain protein explored by Gd3+ electron paramagnetic resonance. Biophysical journal. 2021
  • Hiroshi Nakagawa, Tomohide Saio, Satoshi Ajito, Masaaki Sugiyama, Rintaro Inoue, Michihiro Nagao, Taiki Tominaga, Yukinobu Kawakita. Conformational dynamics of a multi-domain protein by neutron scattering and computational analysis. Biophysical journal. 2021
  • Kamran Rizzolo, Angela Yeou Hsiung Yu, Adedeji Ologbenla, Sa Rang Kim, Haojie Zhu, Koichiro Ishimori, Guillaume Thibault, Elisa Leung, Yi Wen Zhang, Mona Teng, et al. Author Correction: Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex. Nature communications. 2021. 12. 1. 2753-2753
  • Masaki Okumura, Shingo Kanemura, Motonori Matsusaki, Misaki Kinoshita, Tomohide Saio, Dai Ito, Chihiro Hirayama, Hiroyuki Kumeta, Mai Watabe, Yuta Amagai, et al. A unique leucine-valine adhesive motif supports structure and function of protein disulfide isomerase P5 via dimerization. Structure (London, England : 1993). 2021
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MISC (47):
  • KAWAGOE Soichiro, SAIO Tomohide, NAKAGAWA Hiroshi, KUMETA Hiroyuki, ISHIMORI Koichiro. The Catalytic Mechanism of a PPIase Chaperone Investigated by the Structural Analysis at the Transition State Using NMR and MD Simulation. 日本蛋白質科学会年会プログラム・要旨集. 2020. 20th (Web)
  • SAIO Tomohide, ISHIMORI Koichiro. Exploiting paramagnetic metal ions for protein structural study in solution. 生物物理(Web). 2020. 60. Supplement 1-2
  • KAWAMUKAI Honoka, SAIO Tomohide, ISHIMORI Koichiro. Mechanistic insight into dysregulation of FUS liquid-liquid phase separation by toxic repeat peptide. 日本蛋白質科学会年会プログラム・要旨集. 2020. 20th (Web)
  • 中川洋, 斉尾智英, 井上倫太郎, 杉山正明, 長尾道弘, 富永大輝. マルチドメイン蛋白質の階層的な動的構造とダイナミクス. KURNS-EKR (Web). 2020. 6
  • SAIO Tomohide. On and off between molecular chaperones and clients: appropriate distance and timing for protein folding. Abstracts. RIES-Hokudai International Symposium. 2020. 21st (CD-ROM)
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Books (2):
  • Structural Study of Proteins by Paramagnetic Lanthanide Probe Methods
    Springer 2017
  • NMR Structural Biology Using Paramagnetic Lanthanide Probe
    Springer 2016
Lectures and oral presentations  (24):
  • シャペロンから理解する細胞内タンパク質の動態制御メカニズム
    (日本生化学会大会(Web) 2020)
  • On and off between molecular chaperones and clients: appropriate distance and timing for protein folding
    (Abstracts. RIES-Hokudai International Symposium 2020)
  • Mechanistic insight into dysregulation of FUS liquid-liquid phase separation by toxic repeat peptide
    (日本蛋白質科学会年会プログラム・要旨集 2020)
  • Exploiting paramagnetic metal ions for protein structural study in solution
    (生物物理(Web) 2020)
  • タンパク質フォールディングにおける分子シャペロンの機能とメカニズム:立体構造と速度論からのアプローチ
    (日本生化学会大会(Web) 2019)
more...
Education (3):
  • 2008 - 2011 Hokkaido University Ph.D. course
  • 2006 - 2008 Hokkaido University Master course
  • 2002 - 2006 Hokkaido University
Professional career (1):
  • 博士(生命科学) (北海道大学)
Work history (5):
  • 2020/09 - 現在 The University of Tokushima Institute of Advanced Medical Sciences Professor
  • 2014/10 - 2020/08 Hokkaido University Faculty of Science Assistant Professor
  • 2014/10 - 2018/03 Japan Science and Technology Agency (JST)
  • 2011/10 - 2014/09 Rutgers University Chemistry and Chemical Biology Postdoctoral Associate
  • 2011/03 - 2011/09 Hokkaido University Faculty of Advanced Life Science Postdoctoral Assocaite
Committee career (1):
  • 2018 - 現在 Journal of Korean Magnetic Resonance Society Editorial Board
Awards (5):
  • 2018/11 - The Chemical Society of Japan Research Incentive Award Structural basis for proteostasis regulated by molecular chaperones
  • 2018/11 - 日本化学会北海道支部 日本化学会北海道支部研究奨励賞 細胞内恒常性維持を担うシャペロンの動的構造基盤と制御
  • 2014/06 - Protein Science Society of Japan Young Scientist Award Structural Basis for Protein Anti-Aggregation Activity of the Trigger Factor Chaperone
  • 2010/08 - International Conference on Magnetic Resonance in Biological Systems (ICMRBS) 24th ICMRBS Student Poster Award PCS-based structure determination of protein-protein complexes
  • 2008/11 - The Nuclear Magnetic Resonance Society of Japan Young Poster Award in the 47th Annual Meeting of the Nuclear Magnetic Resonance Society of Japan Paramagnetic lanthanide-tagging for protein structural analyses
Association Membership(s) (5):
THE CHEMICAL SOCIETY OF JAPAN ,  THE JAPANESE BIOCHEMICAL SOCIETY ,  PROTEIN SCIENCE SOCIETY OF JAPAN ,  THE NUCLEAR MAGNETIC RESONANCE SOCIETY OF JAPAN ,  日本生物物理学会
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