Saio Tomohide

サイオトモヒデ | Saio Tomohide

Affiliation and department：
Homepage URL (2)： https://www.fujii.tokushima-u.ac.jp/mls/ , http://www.iams.tokushima-u.ac.jp/specialty/

Research field (2)： Molecular biology , Structural biochemistry

Research keywords (6)： Protein folding , molecular chaperone , Protein quality control , structure , protein , NMR

Research theme for competitive and other funds (16)：

2020 - 2023 Structural basis for recognition and regulation of protein folding intermediate by molecular chaperones in the endoplasmic reticulum
2020 - 2023 Regulatory mechanism of biological phase separation
2018 - 2023 新世代中性子構造生物学の開拓
2019 - 2022 半特異的認識を介したシャペロンネットワークの構造基盤
2019 - 2021 相分離を介したシグナル伝達制御の構造基盤

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Papers (34)：

Masahiro Mimura, Shunsuke Tomita, Yoichi Shinkai, Takuya Hosokai, Hiroyuki Kumeta, Tomohide Saio, Kentaro Shiraki, Ryoji Kurita. Quadruplex Folding Promotes the Condensation of Linker Histones and DNAs via Liquid-Liquid Phase Separation. Journal of the American Chemical Society. 2021. 143. 26. 9849-9857
Tomohide Saio, Soya Hiramatsu, Mizue Asada, Hiroshi Nakagawa, Kazumi Shimizu, Hiroyuki Kumeta, Toshikazu Nakamura, Koichiro Ishimori. Conformational ensemble of a multidomain protein explored by Gd3+ electron paramagnetic resonance. Biophysical journal. 2021
Hiroshi Nakagawa, Tomohide Saio, Satoshi Ajito, Masaaki Sugiyama, Rintaro Inoue, Michihiro Nagao, Taiki Tominaga, Yukinobu Kawakita. Conformational dynamics of a multi-domain protein by neutron scattering and computational analysis. Biophysical journal. 2021
Kamran Rizzolo, Angela Yeou Hsiung Yu, Adedeji Ologbenla, Sa Rang Kim, Haojie Zhu, Koichiro Ishimori, Guillaume Thibault, Elisa Leung, Yi Wen Zhang, Mona Teng, et al. Author Correction: Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex. Nature communications. 2021. 12. 1. 2753-2753
Masaki Okumura, Shingo Kanemura, Motonori Matsusaki, Misaki Kinoshita, Tomohide Saio, Dai Ito, Chihiro Hirayama, Hiroyuki Kumeta, Mai Watabe, Yuta Amagai, et al. A unique leucine-valine adhesive motif supports structure and function of protein disulfide isomerase P5 via dimerization. Structure (London, England : 1993). 2021

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MISC (47)：

KAWAGOE Soichiro, SAIO Tomohide, NAKAGAWA Hiroshi, KUMETA Hiroyuki, ISHIMORI Koichiro. The Catalytic Mechanism of a PPIase Chaperone Investigated by the Structural Analysis at the Transition State Using NMR and MD Simulation. 日本蛋白質科学会年会プログラム・要旨集. 2020. 20th (Web)
SAIO Tomohide, ISHIMORI Koichiro. Exploiting paramagnetic metal ions for protein structural study in solution. 生物物理(Web). 2020. 60. Supplement 1-2
KAWAMUKAI Honoka, SAIO Tomohide, ISHIMORI Koichiro. Mechanistic insight into dysregulation of FUS liquid-liquid phase separation by toxic repeat peptide. 日本蛋白質科学会年会プログラム・要旨集. 2020. 20th (Web)
中川洋, 斉尾智英, 井上倫太郎, 杉山正明, 長尾道弘, 富永大輝. マルチドメイン蛋白質の階層的な動的構造とダイナミクス. KURNS-EKR (Web). 2020. 6
SAIO Tomohide. On and off between molecular chaperones and clients: appropriate distance and timing for protein folding. Abstracts. RIES-Hokudai International Symposium. 2020. 21st (CD-ROM)

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Books (2)：

Structural Study of Proteins by Paramagnetic Lanthanide Probe Methods
Springer 2017
NMR Structural Biology Using Paramagnetic Lanthanide Probe
Springer 2016

Lectures and oral presentations (24)：

シャペロンから理解する細胞内タンパク質の動態制御メカニズム
(日本生化学会大会(Web) 2020)
On and off between molecular chaperones and clients: appropriate distance and timing for protein folding
(Abstracts. RIES-Hokudai International Symposium 2020)
Mechanistic insight into dysregulation of FUS liquid-liquid phase separation by toxic repeat peptide
(日本蛋白質科学会年会プログラム・要旨集 2020)
Exploiting paramagnetic metal ions for protein structural study in solution
(生物物理(Web) 2020)
タンパク質フォールディングにおける分子シャペロンの機能とメカニズム:立体構造と速度論からのアプローチ
(日本生化学会大会(Web) 2019)

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Education (3)：

2008 - 2011 Hokkaido University Ph.D. course
2006 - 2008 Hokkaido University Master course
2002 - 2006 Hokkaido University

Professional career (1)：

博士(生命科学) (北海道大学)

Work history (5)：

2020/09 - 現在 The University of Tokushima Institute of Advanced Medical Sciences Professor
2014/10 - 2020/08 Hokkaido University Faculty of Science Assistant Professor
2014/10 - 2018/03 Japan Science and Technology Agency (JST)
2011/10 - 2014/09 Rutgers University Chemistry and Chemical Biology Postdoctoral Associate
2011/03 - 2011/09 Hokkaido University Faculty of Advanced Life Science Postdoctoral Assocaite

Committee career (1)：

2018 - 現在 Journal of Korean Magnetic Resonance Society Editorial Board

Awards (5)：

2018/11 - The Chemical Society of Japan Research Incentive Award Structural basis for proteostasis regulated by molecular chaperones
2018/11 - 日本化学会北海道支部日本化学会北海道支部研究奨励賞細胞内恒常性維持を担うシャペロンの動的構造基盤と制御
2014/06 - Protein Science Society of Japan Young Scientist Award Structural Basis for Protein Anti-Aggregation Activity of the Trigger Factor Chaperone
2010/08 - International Conference on Magnetic Resonance in Biological Systems (ICMRBS) 24th ICMRBS Student Poster Award PCS-based structure determination of protein-protein complexes
2008/11 - The Nuclear Magnetic Resonance Society of Japan Young Poster Award in the 47th Annual Meeting of the Nuclear Magnetic Resonance Society of Japan Paramagnetic lanthanide-tagging for protein structural analyses

Association Membership(s) (5)：

THE CHEMICAL SOCIETY OF JAPAN , THE JAPANESE BIOCHEMICAL SOCIETY , PROTEIN SCIENCE SOCIETY OF JAPAN , THE NUCLEAR MAGNETIC RESONANCE SOCIETY OF JAPAN , 日本生物物理学会

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