Research field (2):
Molecular biology
, Structural biochemistry
Research keywords (6):
Protein folding
, molecular chaperone
, Protein quality control
, structure
, protein
, NMR
Research theme for competitive and other funds (21):
2023 - 2028 Molecular dissection of plant specialized metabolism machineries
2023 - 2026 Stratification of Protein Aggregation States based on Pattern Recognition for Screening Factors Controlling Phase Separation
2022 - 2025 Mechanism of chaperone activity modulation through promiscuous recognitions
2021 - 2024 Unraveling the mechanism of kinetic regulation in biomolecular folding
2021 - 2024 Organization of kinetics-driven supramolecular chemistry
2020 - 2023 Structural basis for recognition and regulation of protein folding intermediate by molecular chaperones in the endoplasmic reticulum
2020 - 2023 Regulatory mechanism of biological phase separation
2018 - 2023 Neutron Structural Biology for New Generation
2019 - 2022 Structural basis for chaperone network mediated by semi-specific recognitions
2019 - 2021 相分離を介したシグナル伝達制御の構造基盤
2017 - 2019 分子シャペロンの基質選択と活性発現における動的構造基盤
2017 - 2019 NMRを主体としたタンパク質構造推移解析のための複合手法の開発と応用
2016 - 2019 Dynamic Structural Characterization of Electron Transfer Complex in Respiratory Chain of Mitochondria and Its Electron Transfer Regulation Mechanism
2017 - 2019 分子シャペロンの基質選択と活性発現における動的構造基盤
2015 - 2019 NMRを主体としたタンパク質構造推移解析のための複合手法の開発と応用
2014 - 2018 過渡的複合体を介したシャペロンネットワークの分子機構解明
2015 - 2017 NMRを主体としたタンパク質構造推移解析のための複合手法の開発と応用
2015 - 2017 Analysis of respiratory electron transport chain using the paramagnetic probes
2015 - 2017 常磁性プローブを用いた呼吸鎖における電子伝達機構の解析
2013 - 2016 Functional and Structural Characterization of Electron Transfer Reactions in Mitochondria Respiratory Chain Utilizing Nanodisc
Honoka Kawamukai, Motonori Matsusaki, Takanari Tanimoto, Mai Watabe, Ken Morishima, Shunsuke Tomita, Yoichi Shinkai, Tatsuya Niwa, Taro Mannen, Hiroyuki Kumeta, et al. Conserved loop of a phase modifier endows protein condensates with fluidity. 2024
Tomohide Saio, Kotone Ishii, Motonori Matsusaki, Hiroyuki Kumeta, Shingo Kanemura, Masaki Okumura. Client recognition differences between PDI and ERp46 to guide oxidative folding. bioRxiv. 2024
Takahiro Muraoka, Masaki Okumura, Tomohide Saio. Enzymatic and synthetic regulation of polypeptide folding. Chemical science. 2024. 15. 7. 2282-2299
Honoka Kawamukai, Shumpei Takishita, Kazumi Shimizu, Daisuke Kohda, Koichiro Ishimori, Tomohide Saio. Conformational Distribution of a Multidomain Protein Measured by Single-Pair Small-Angle X-ray Scattering. The Journal of Physical Chemistry Letters. 2024. 15. 3. 744-750
Integrative Structural Study on a Multidomain Protein Enzyme Utilizing Paramagnetic Lanthanide Ion
(2023 Asia-Pacific NMR Symposium 2023)
Structural and kinetic views of regulators for protein folding and assembly
(International Symposium on Protein Folding, Aggregation, Misfolding Disease, and Disease Crosstalk 2023)
Visualizing conformational changes of a multidomain protein enzyme using paramagnetic probes
(International Society of Magnetic Resonance (ISMAR) 2023 conference 2023)
2014/06 - Protein Science Society of Japan Young Scientist Award Structural Basis for Protein Anti-Aggregation Activity of the Trigger Factor Chaperone
2010/08 - International Conference on Magnetic Resonance in Biological Systems (ICMRBS) 24th ICMRBS Student Poster Award PCS-based structure determination of protein-protein complexes
2008/11 - The Nuclear Magnetic Resonance Society of Japan Young Poster Award in the 47th Annual Meeting of the Nuclear Magnetic Resonance Society of Japan Paramagnetic lanthanide-tagging for protein structural analyses
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Association Membership(s) (5):
THE CHEMICAL SOCIETY OF JAPAN
, THE JAPANESE BIOCHEMICAL SOCIETY
, PROTEIN SCIENCE SOCIETY OF JAPAN
, THE NUCLEAR MAGNETIC RESONANCE SOCIETY OF JAPAN
, 日本生物物理学会