Rchr
J-GLOBAL ID：201501057964770260
Update date: Apr. 12, 2026
Kimura Yasuyuki
キムラ ヤスユキ | Kimura Yasuyuki
Affiliation and department：
Other affiliations (3)：
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National Institutes for Quantum and Radiological Science and Technology
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Fujita Health University
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Gifu University
Homepage URL (1)：
https://kaken.nii.ac.jp/d/r/20423171.ja.html
Research field (1)：
Radiology
Research keywords (6)：
PET
, positron emission tomography
, Alzheimer's disease
, neuroinflammation
, microglia
, ポジトロンエミッショントモグラフィー
Research theme for competitive and other funds (21)：
- 2024 - 2028 PET and postmortem brain study of secondary tauopathies following CNS diseases
- 2024 - 2027 Evaluation of a PET imaging ligand for microglia in Alzheimer's diseases
- 2023 - 2026 Synthesis of functional PET probes targeting enzymes specifically expressed in glioma
- 2023 - 2025 Development of an in vivo cell tracking method using biological orthogonal reactions and PET
- 2022 - 2025 アルツハイマー病前臨床期の血液およびPETバイオマーカーの有用性に関する調査研究
- 2022 - 2025 The research of the systemic inflammation as a cause of neuropsychiatric symptoms in Alzheimer's disease
- 2021 - 2024 Development of PET imaging of brain immunity as a biomarker for drug development to treat neurodegenerative diseases
- 2021 - 2023 Development of brain PET imaging using bioorthogonal reactions
- 2020 - 2023 特異的発現酵素を標的とした脳腫瘍イメージングPETプローブの斬新化
- 2019 - 2022 In vivo investigation of neuroinflammation of AD with PET molecular imaging
- 2018 - 2021 PET imaging of microglia, a novel drug target for neurodegenerative diseases
- 2018 - 2021 Synthesis of 11C-labeled acyclic retinoids with high brain permeability
- 2019 - 2021 ミクログリア機能を反映するPETイメージングの開発
- 2017 - 2020 PET microdose study for finding appropriate dose of isoproterenol as a disease modifying treatment of dementia
- 2016 - 2020 うつ病の病態に基づく層別化と神経回路調整による革新的診断・治療法開発
- 2017 - 2019 認知症の新規診断・治療薬の薬物動態評価のためのPET first-in-human試験
- 2017 - 2019 (放射性標識)新規AMPA受容体PETイメージング製剤によるてんかん焦点同定の補助診断薬としての臨床開発
- 2015 - 2018 Quantitative PET imaging of AMPA receptors in humans
- 2014 - 2018 Tau PET study for revealing the pathogenesis and establishing the objective marker of disease severity in neurodegenerative dementia
- 2015 - 2017 AMPA型グルタミン酸受容体のヒトにおけるPET定量イメージングの確立
- 2012 - 2015 PET measurements of interaction between glutamatergic and dopaminergic neurons
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Papers (220)：
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Kosei Ueno, Yoshikazu Tanaka, Yusuke Sato, Takeshi Yokoyama, Atsushi Natsume, Takao Yasui, Shota Kawaguchi, Rina Mitsuya, Zetao Zhu, Kimiko Inoue, et al. Glomerular routing of tumor-derived extracellular vesicles substantiates urinary biopsy. Science Advances. 2026
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Fumihiko Yasuno, Yasuyuki Kimura, Takashi Nihashi, Hiroyuki Minami, Hikaru Minami, Akinori Takeda, Takashi Sakurai, Takashi Kato. Frontostriatal volumes and anterior thalamic mediation of late-life depressive symptoms across the cognitive spectrum from normal aging to Alzheimer’s disease: A structural equation modelling study. International Psychogeriatrics. 2026
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Kiwamu Matsuoka, Yuhei Takado, Yasuyuki Kimura, Akihiko Kitamura, Hitomi Kitamura, Mayuka Kanda, Michihiro Takada, Maiko Ono, Harutsugu Tatebe, Hironobu Endo, et al. Quantification of monoamine oxidase B expression with 11C-SL25.1188 for imaging reactive astrocytes in patients with Alzheimer’s disease. European Journal of Nuclear Medicine and Molecular Imaging. 2026
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Yoshiki Ooshima, Hiroko Koyama, Aya Ogata, Hiroshi Ikenuma, Takashi Yamada, Hiroyuki Kojima, Takashi Kato, Yasuyuki Kimura, Masaaki Suzuki. 11C-labeling of 20(S)-protopanaxadiol, an aglycon of ginsenoside, based on the use of Pd(0)-mediated rapid C-[11C]methylation of boronic precursors. Bioorganic & medicinal chemistry letters. 2025. 128. 130356-130356
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Fumihiko Yasuno, Atsushi Watanabe, Yasuyuki Kimura, Yumeka Yamauchi, Aya Ogata, Hiroshi Ikenuma, Junichiro Abe, Hiroyuki Minami, Takashi Nihashi, Kastunori Yokoi, et al. Plasma IL-6 Levels as a Biomarker for Behavioral Changes in Alzheimer’s Disease. Neuroimmunomodulation. 2025
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MISC (184)：
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安野史彦, 安野史彦, 中込和幸, 大町佳永, 木村泰之, 木村泰之, 小縣綾, 小縣綾, 阿部潤一郎, 南博之, et al. レプチン:炎症を介して肥満と認知症の精神症状を結びつける媒介因子としての役割. 老年精神医学雑誌. 2025. 36
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田中絵実, 二橋尚志, 横井克典, 今井和憲, 木村泰之, 加藤隆司, 中村昭範. A case report of pathophysiological analysis combining MEG and PET in a patient with dementia and epilepsy. 日本生体磁気学会誌. 2025. 38. 1
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尾崎和, 池沼宏, 阿部潤一郎, 戸次雄一, 山田貴史, 加藤隆司, 木村泰之, 小縣綾, 小縣綾. Development of a novel PET ligand targeting the P2Y purinoceptor 12. 日本薬学会年会要旨集(Web). 2025. 145th
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境崇行, 境崇行, 池沼宏, 山田貴史, 山田貴史, 小縣綾, 小縣綾, 市瀬正則, 他田真理, 柿田明美, et al. グルコーストランスポーター1を標的とする脳PETイメージングリガンドの開発. 核医学(Web). 2024. 61. Supplement
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小縣綾, 小縣綾, 池沼宏, 二橋尚志, 安野史彦, 安野史彦, 市瀬正則, 服部沙織, 佐藤弥生, 森下浩, et al. ミクログリア特異的に発現するCSF1Rを標的とした新規脳PET製剤[11C]NCGG401のFirst in human試験. 核医学(Web). 2023. 60. Supplement
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Patents (1)：
Lectures and oral presentations (106)：
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PETを用いた大脳皮質基底核症候群の背景病理推定に関する検討
(パーキンソン病・運動障害疾患コングレスプログラム・抄録集 2019)
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18F-PM-PBB3 PETは発症前駆期より4リピートタウオパチーの脳病理を捕捉し得る
(パーキンソン病・運動障害疾患コングレスプログラム・抄録集 2019)
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Relationship between the accumulation of THK-5351 and PiB in each cerebral region from cognitively normal to Alzheimer type dementia, a PET study
(JOURNAL OF NUCLEAR MEDICINE 2019)
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18F-PM-PBB3 PETによる4リピートタウオパチーのタウイメージング
(千葉医学雑誌 2019)
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AD continuumにおけるTHK-5351集積と脳萎縮との領域間相関の検討
(核医学 2018)
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Education (2)：
- 2002 - 2006 Osaka University Graduate School of Medicine
- 1992 - 1998 Osaka University
Professional career (2)：
- MD (Osaka University)
- PhD (Osaka University Graduate School of Medicine)
Work history (6)：
- 2021/04 - 現在 国立研究開発法人 国立長寿医療研究センター 認知症先進医療開発センター 脳機能画像診断開発部 副部長
- 2016/10 - 2021/03 National Center for Geriatrics and Gerontology Department of Clinical and Experimental Neuroimaging, Center for Development of Advanced Medicine for Dementia Chief, Section of Imaging Molecules
- 2014/07 - 2016/09 National Institute of Radiological Sciences Molecular Imaging Center Senior researcher
- 2010/10 - 2014/06 National Institutes for Quantum and Radiological Science and Technology
- 2007/12 - 2010/09 National Institute of Mental Health Molecular Imaging Branch Visiting Fellow
- 2006/05 - 2006/07 Imperial College, Hammersmith Hospital MRC Clinical Sciences Centre and Division of Neuroscience Visitor
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Committee career (3)：
- 2022/10 - 現在 量子科学技術研究開発機構 臨床研究審査委員会委員
- 2022/06 - 現在 量子科学技術研究開発機構 PET薬剤審査委員会委員
- 2021/05 - 現在 量子科学技術研究開発機構 認定倫理審査委員会 技術専門員
Awards (4)：
- 2020/08 - The 14th International Conference on Complex Medical and Engineering (CME2020) Best Conference Paper Award PET Imaging in Drug Development for Neurodegenerative Diseases
- 2014 - Travel awarded winner of the Asian Youth Forum of Nuclear Medicine and Molecular Imaging
- 2011 - 第50回千葉核医学賞
- 2005 - 大阪難病研究財団 海外派遣助成
Association Membership(s) (2)：
THE JAPANESE SOCIETY OF INTERNAL MEDICINE
, JAPANESE SOCIETY OF NUCLEAR MEDICINE
