Kimura Yasuyuki

キムラヤスユキ | Kimura Yasuyuki

Affiliation and department：
Other affiliations (3)：

National Institutes for Quantum and Radiological Science and Technology
Fujita Health University
Gifu University

Homepage URL (1)： https://kaken.nii.ac.jp/d/r/20423171.ja.html

Research field (1)： Radiology

Research keywords (6)： PET , positron emission tomography , Alzheimer's disease , neuroinflammation , microglia , ポジトロンエミッショントモグラフィー

Research theme for competitive and other funds (19)：

2023 - 2026 Synthesis of functional PET probes targeting enzymes specifically expressed in glioma
2023 - 2025 Development of an in vivo cell tracking method using biological orthogonal reactions and PET
2022 - 2025 アルツハイマー病前臨床期の血液およびPETバイオマーカーの有用性に関する調査研究
2022 - 2025 The research of the systemic inflammation as a cause of neuropsychiatric symptoms in Alzheimer's disease
2021 - 2024 Development of PET imaging of brain immunity as a biomarker for drug development to treat neurodegenerative diseases

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Papers (172)：

Hiroshi Ikenuma, Aya Ogata, Hiroko Koyama, Bin Ji, Hideki Ishii, Takashi Yamada, Junichiro Abe, Chie Seki, Yuji Nagai, Masanori Ichise, et al. Synthesis and evaluation of a novel PET ligand, a GSK'963 analog, aiming at autoradiography and imaging of the receptor interacting protein kinase 1 in the brain. EJNMMI radiopharmacy and chemistry. 2023. 8. 1. 31-31
Takayuki Sakai, Saori Hattori, Aya Ogata, Takashi Yamada, Junichiro Abe, Hiroshi Ikenuma, Masanori Ichise, Masaaki Suzuki, Kengo Ito, Takashi Kato, et al. Noradrenaline transporter PET reflects neurotoxin-induced noradrenaline level decrease in the rat hippocampus. EJNMMI research. 2023. 13. 1. 82-82
Keita Sakurai, Daita Kaneda, Satoru Morimoto, Yuto Uchida, Shohei Inui, Yasuyuki Kimura, Takashi Kato, Kengo Ito, Yoshio Hashizume. Asymmetric Cerebral Peduncle Atrophy: A Simple Diagnostic Clue for Distinguishing Frontotemporal Lobar Degeneration from Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023
Fumihiko Yasuno, Yasuyuki Kimura, Aya Ogata, Hiroshi Ikenuma, Junichiro Abe, Hiroyuki Minami, Takashi Nihashi, Kastunori Yokoi, Saori Hattori, Nobuyoshi Shimoda, et al. Neuroimaging biomarkers of glial activation for predicting the annual cognitive function decline in patients with Alzheimer's disease. Brain, behavior, and immunity. 2023
Yasuharu Yamamoto, Keisuke Takahata, Manabu Kubota, Hiroyoshi Takeuchi, Sho Moriguchi, Takeshi Sasaki, Chie Seki, Hironobu Endo, Kiwamu Matsuoka, Kenji Tagai, et al. Association of protein distribution and gene expression revealed by positron emission tomography and postmortem gene expression in the dopaminergic system of the human brain. European journal of nuclear medicine and molecular imaging. 2023

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MISC (170)：

Hiroshi Ikenuma, Aya Ogata, Hiroko Koyama, Takashi Yamada, Junichiro Abe, Masanori Ichise, Takashi Kato, Masaaki Suzuki, Kengo Ito, Yasuyuki Kimura. Development of novel PET ligands to image the receptor interacting protein kinase 1. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2021. 41. 1_SUPPL. 39-40
Aya Ogata, Takashi Yamada, Junichiro Abe, Masanori Ichise, Hiroshi Ikenuma, Hiroko Koyama, Masaaki Suzuki, Takashi Kato, Kengo Ito, Yasuyuki Kimura. PET imaging of [C-11]NCGG401 for colony stimulating factor 1 receptor. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2021. 41. 1_SUPPL. 42-42
Takayuki Sakai, Takashi Yamada, Hiroshi Ikenuma, Aya Ogata, Masanori Ichise, Saori Hattori, Junichiro Abe, Masaaki Suzuki, Kengo Ito, Takashi Kato, et al. Development of a novel PET ligand for receptor-interacting protein kinase 1 in brain. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2021. 41. 1_SUPPL. 119-119
境崇行, 服部沙織, 小縣綾, 小縣綾, 山田貴史, 山田貴史, 阿部潤一郎, 池沼宏, 市瀬正則, 鈴木正昭, et al. PETイメージングを用いたラット脳内NET密度測定とNE濃度に関する研究. 核医学(Web). 2021. 58. Supplement
大島禎生, 古山浩子, 小縣綾, 池沼宏, 木村泰之, 加藤隆司, 鈴木正昭. 中枢神経保護作用をもつギンセノシド類の¹¹C-標識化とPETイメージング. 中部化学関係学協会支部連合秋季大会講演予稿集. 2021. 52nd (CD-ROM)

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Patents (1)：

V1b受容体の放射性標識リガンド

Lectures and oral presentations (106)：

PETを用いた大脳皮質基底核症候群の背景病理推定に関する検討
(パーキンソン病・運動障害疾患コングレスプログラム・抄録集 2019)
18F-PM-PBB3 PETは発症前駆期より4リピートタウオパチーの脳病理を捕捉し得る
(パーキンソン病・運動障害疾患コングレスプログラム・抄録集 2019)
Relationship between the accumulation of THK-5351 and PiB in each cerebral region from cognitively normal to Alzheimer type dementia, a PET study
(JOURNAL OF NUCLEAR MEDICINE 2019)
18F-PM-PBB3 PETによる4リピートタウオパチーのタウイメージング
(千葉医学雑誌 2019)
AD continuumにおけるTHK-5351集積と脳萎縮との領域間相関の検討
(核医学 2018)

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Education (2)：

2002 - 2006 Osaka University Graduate School of Medicine
1992 - 1998 Osaka University

Professional career (2)：

MD (Osaka University)
PhD (Osaka University Graduate School of Medicine)

Work history (6)：

2021/04 - 現在国立研究開発法人国立長寿医療研究センター認知症先進医療開発センター脳機能画像診断開発部副部長
2016/10 - 2021/03 National Center for Geriatrics and Gerontology Department of Clinical and Experimental Neuroimaging, Center for Development of Advanced Medicine for Dementia Chief, Section of Imaging Molecules
2014/07 - 2016/09 National Institute of Radiological Sciences Molecular Imaging Center Senior researcher
2010/10 - 2014/06 National Institutes for Quantum and Radiological Science and Technology
2007/12 - 2010/09 National Institute of Mental Health Molecular Imaging Branch Visiting Fellow

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Committee career (3)：

2022/10 - 現在量子科学技術研究開発機構臨床研究審査委員会委員
2022/06 - 現在量子科学技術研究開発機構 PET薬剤審査委員会委員
2021/05 - 現在量子科学技術研究開発機構認定倫理審査委員会技術専門員

Awards (4)：

2020/08 - The 14th International Conference on Complex Medical and Engineering (CME2020) Best Conference Paper Award PET Imaging in Drug Development for Neurodegenerative Diseases
2014 - Travel awarded winner of the Asian Youth Forum of Nuclear Medicine and Molecular Imaging
2011 - 第50回千葉核医学賞
2005 - 大阪難病研究財団海外派遣助成

Association Membership(s) (2)：

THE JAPANESE SOCIETY OF INTERNAL MEDICINE , JAPANESE SOCIETY OF NUCLEAR MEDICINE

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