Rchr
J-GLOBAL ID：201501077719678317   Update date: Apr. 10, 2024

OCHIAI HIROSHI

オチアイ ヒロシ | OCHIAI HIROSHI
Affiliation and department：
Kyushu University Division of Gene Expression Dynamics, Medical Research Center Initiative for High Depth Omics, Medical Institute of Bioregulation

About Kyushu University Division of Gene Expression Dynamics, Medical Research Center Initiative for High Depth Omics, Medical Institute of Bioregulation


Job title： Professor
Homepage URL  (2)： https://www.bioreg.kyushu-u.ac.jp/labo/ged/ ,  https://www.bioreg.kyushu-u.ac.jp/labo/ged/en/
Research field  (4)： Genomics ,  Environmental effects of chemicals ,  Environmental effects of radiation ,  Systems genomics
Research keywords  (14)： SNP ,  遺伝子ターゲティング ,  一塩基置換 ,  遺伝病 ,  遺伝子挿入 ,  TALEN ,  zinc-finger nuclease ,  ゲノム編集 ,  Gene expression noise ,  Live imaging ,  CRISPR ,  ES cell ,  pluripotent stem cells ,  single cell analysis
Research theme for competitive and other funds  (23)：
  • 2024 - 2029 哺乳類初期発生における細胞可塑性を制御するエピコードの解読
  • 2023 - 2029 Understanding the mammalian cell fate regulation framework through multimodal spatiotemporal integrated omics analysis
  • 2022 - 2025 Elucidation of the linkage between higher-order genome structural dynamics and gene expression
  • 2023 - 2025 転写動態制御を担うゲノムモダリティ要因の理解
  • 2022 - 2024 Elucidation of the linkage between non-genomic information replication and transcriptional dynamics between sister chromatids
Show all
Papers (32)：
  • Hiroaki Ohishi, Soya Shinkai, Hitoshi Owada, Takeru Fujii, Kazufumi Hosoda, Shuichi Onami, Takashi Yamamoto, Yasuyuki Ohkawa, Hiroshi Ochiai. Transcription-coupled changes in higher-order genomic structure and transcription hub viscosity prolong enhancer-promoter connectivity. bioRxiv. 2023
  • Kosuke Tomimatsu, Takeru Fujii, Ryoma Bise, Kazufumi Hosoda, Yosuke Taniguchi, Hiroshi Ochiai, Hiroaki Ohishi, Kanta Ando, Ryoma Minami, Tachibana Taro, et al. Precise immunofluorescence canceling for highly multiplexed imaging capturing specific cell state. bioRxiv. 2023
  • Hiroaki Ohishi, Seiru Shimada, Satoshi Uchino, Jieru Li, Yuko Sato, Manabu Shintani, owada hitoshi, Yasuyuki Ohkawa, Alexandros Pertsinidis, Takashi Yamamoto, et al. STREAMING-tag system reveals spatiotemporal relationships between transcriptional regulatory factors and transcriptional activity. Nature Communications. 2022. 13. 1. 7672
  • Haruka Matsumori, Kenji Watanabe, Hiroaki Tachiwana, Tomoko Fujita, Yuma Ito, Makio Tokunaga, Kumiko Sakata-Sogawa, Hiroko Osakada, Tokuko Haraguchi, Akinori Awazu, Hiroshi Ochiai, Yuka Sakata, Koji Ochiai, Tsutomu Toki, Etsuro Ito, Ilya G Goldberg, Kazuaki Tokunaga, Mitsuyoshi Nakao, Noriko Saitoh. Ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly. Life Science Alliance. 2022. 5. 7. e202101045
  • Silvia Natsuko Akutsu, Tatsuo Miyamoto, Daiju Oba, Keita Tomioka, Hiroshi Ochiai, Hirofumi Ohashi, Shinya Matsuura. iPSC reprogramming-mediated aneuploidy correction in autosomal trisomy syndromes. PLoS One. 2022. 17. 3. e0264965
ｍore...
MISC (28)：
  • 落合 博, 大川 恭行. 創薬研究を加速する空間オミクス技術. 実験医学増刊 あなたのラボから薬を生み出す アカデミア創薬の実践 All JAPAN体制の先端技術支援を利用した創薬の最前線. 2024. 42. 2
  • Hiroshi Ochiai, Hiroaki Ohishi, Yuko Sato, Hiroshi Kimura. Organization of transcription and 3D genome as revealed by live-cell imaging. Current Opinion in Structural Biology. 2023. 81. 102615-102615
  • Hiroshi Ochiai. Facilitating genome function understanding using genome editing dependent bioimaging techniques. Gene and Genome Editing. 2023. 5. 100022
  • 大石裕晃, 落合 博. 特定RNA分子/DNA領域のライブイメージング技術. 生体の科学. 2023. 74. 3. 260-265
  • Hiroshi Ochiai. Fluctuation and Biological Function. The Cell. 2023. 55. 3
ｍore...
Patents (3)：
  • 複数蛍光色素定量方法および装置
  • 細胞の作製方法および該作製方法で作製された細胞
  • DNA結合ドメインを含むポリペプチド
Books (7)：
  • 実験医学別冊 最強のステップUPシリーズ エピゲノムをもっと見るためのクロマチン解析実践プロトコール (大川恭行,宮成悠介/編)
    羊土社 2020 ISBN:9784758122481
  • 実験医学別冊 完全版 ゲノム編集実験スタンダード CRISPR-Cas9の設計・作製と各生物種でのプロトコールを徹底解説 (山本 卓,佐久間哲史/編)
    羊土社 2019
  • 医療応用をめざすゲノム編集 最新動向から技術・倫理的課題まで 真下 知士/金田 安史編
    KAGAKUDOJIN 2018
  • Genome Editing in Animals
    Springer New York 2017 ISBN:9781493971282
  • All Aboutゲノム編集 “革命的技術”はいかにして私たちの研究・医療・産業を変えるのか? 真下知士,山本 卓/編
    羊土社 2016 ISBN:9784758103596
ｍore...
Lectures and oral presentations  (62)：
  • 空間オミクス技術で切り開く生命現象の高深度理解
    (2024医療・健康ユニットシンポジウム 2024)
  • 遺伝子発現における転写バースト 〜細胞レベルでの影響と制御機構〜
    (第1回WS「未踏探索における個性と集団の役割」 2024)
  • Unveiling transcriptional dynamics in pluripotent stem cells through imaging analysis
    (RIKEN IMS Seminar 2024)
  • Regulation of gene expression dynamics in pluripotent stem cells revealed by imaging analysis
    (RIKEN BDR Seminar 2024)
  • Changes in higher-order genomeic structures during transcriptional dynamics revealed by multimodal chromatin tracing
    (The 46th Annual Meeting of the Molecular Biology Society of Japan 2023)
ｍore...
Education (3)：
  • 2008 - 2011 Hiroshima University Graduate School, Division of Natural Science Department of Mathematical and Life Sciences
  • 2007 - 2008 Hiroshima University Graduate School, Division of Natural Science Department of Mathematical and Life Sciences
  • 2003 - 2007 Hiroshima University Faculty of Science Departmet of Biological Science
Professional career (1)：
  • PhD (Science) (Hiroshima University)
Work history (8)：
  • 2023/03 - 現在 Kyushu University Division of Gene Expression Dynamics, Medical Research Center Initiative for High Depth Omics, Medical Institute of Bioregulation Professor
  • 2021/04 - 2023/02 Hiroshima University Graduate School of Integrated Sciences for Life Associate Professor
  • 2019/04 - 2021/03 Hiroshima University Graduate School of Integrated Sciences for Life Lecturer
  • 2015/10/01 - 2019/03/31 Japan Science and Technology Agency Graduate School of Science, Department of Mathematical and Life Sciences, Hiroshima University PRESTO researcher
  • 2013/04/01 - 2015/09/30 Hiroshima University Graduate School of Science Lecturer (Special Appointment)
Show all
Committee career (8)：
  • 2022/01 - 2024/12 Associate Editor of Journal of Biochemistry
  • 2021/08 - 2023/07 Ministry of Education, Culture, Sports, Science and Technology - Japan Senior Scientific Research Specialist, Grants-in-Aid for Scientific Research (KAKENHI)
  • 2022/10 - 2023/06 8th Annual Meeting of the Japanese Society for Genome Editing Conference Preparation Committee
  • 2022/03 - 2022/04 日本ゲノム編集学会 日本ゲノム編集学会 選挙管理委員長
  • 2015/07 - 2021/05 Editorial Board Member
Show all
Awards (6)：
  • 2023/06 - 日本エピジェネティクス研究会 日本エピジェネティクス研究会第16回年会 奨励賞 生細胞単一遺伝子イメージングによる転写動態のエピジェネティック制御機構の解明
  • 2021/10 - Hiroshima University Distinguished Researcher
  • 2021/05/11 - 広島大学 広島大学大学院統合生命科学研究科 統合生命科学研究科奨励賞
  • 2016/11 - Hiroshima University President Award
  • 2008/06 - Hiroshima University Excellent Student Scholarship
Show all
Association Membership(s) (4)：
THE BIOPHYSICAL SOCIETY OF JAPAN ,  The Japanese society for Genome Editing ,  The Japanese Society for Epigenetics ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page

TOP

BOTTOM