Rchr
J-GLOBAL ID：201501099525495940   Update date: Apr. 20, 2024

Takatori Sho

タカトリ シヨウ | Takatori Sho
Affiliation and department：
The University of Tokyo Graduate School of Pharmaceutical Sciences

About The University of Tokyo Graduate School of Pharmaceutical Sciences


Homepage URL  (1)： https://kaken.nii.ac.jp/d/r/80624361.ja.html
Research field  (2)： Pharmaceuticals - health and biochemistry ,  Cell biology
Research keywords  (6)： 包括脳ネットワーク ,  急速凍結 ,  凍結割断レプリカ標識法 ,  膜脂質 ,  セクレターゼ ,  アルツハイマー病
Research theme for competitive and other funds  (9)：
  • 2022 - 2025 アルツハイマー病神経変性過程におけるミクログリアによる神経食作用の病的意義解明
  • 2019 - 2023 認知症発症機構における神経変性プロセスの鍵を握る細胞病態の解明
  • 2019 - 2022 Elucidation of the pathological roles of phosphoinositide signaling in microglia
  • 2017 - 2019 アルツハイマー病におけるミクログリア脂質シグナル経路の病的意義の解明
  • 2015 - 2018 Cell biological studies on membrane lipid distribution and dynamics
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Papers (27)：
  • Yutaka Takeda, Takumi Chinen, Shunnosuke Honda, Sho Takatori, Shotaro Okuda, Shohei Yamamoto, Masamitsu Fukuyama, Koh Takeuchi, Taisuke Tomita, Shoji Hata, et al. Molecular basis promoting centriole triplet microtubule assembly. Nature Communications. 2024. 15. 1
  • Yuma Kato, Sho Takatori, Aika Akahori, Hayato Etani, Yung Ning Chu, Taisuke Tomita. Protocol for gene knockdown using siRNA in primary cultured neonatal murine microglia. STAR protocols. 2024. 5. 1. 102867-102867
  • Tetsuro Abe, Tomoki Kuwahara, Shoichi Suenaga, Maria Sakurai, Sho Takatori, Takeshi Iwatsubo. Lysosomal stress drives the release of pathogenic α-synuclein from macrophage lineage cells via the LRRK2-Rab10 pathwayy. iScience. 2024. 27. 2. 108893
  • Yuki Hayashi, Sho Takatori, Waleed Y Warsame, Taisuke Tomita, Takao Fujisawa, Hidenori Ichijo. TOLLIP acts as a cargo adaptor to promote lysosomal degradation of aberrant ER membrane proteins. The EMBO journal. 2023. e114272
  • Akihiro Iguchi, Sho Takatori, Shingo Kimura, Hiroki Muneto, Kai Wang, Hayato Etani, Genta Ito, Haruaki Sato, Yukiko Hori, Junko Sasaki, et al. INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model. iScience. 2023. 26. 4. 106375-106375
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MISC (24)：
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Lectures and oral presentations  (8)：
  • Analysis of the effects of INPP5D/SHIP1 deficiency on amyloid pathology in Alzheimer model mice
    (EMBO/EMBL Symposium: Mechanisms of Neurodegeneration 2017)
  • Analysis of the pathological role of an Alzheimer’s disease genetic risk factor, INPP5D/SHIP1
    (2016)
  • Heterogeneous distribution of phospholipids in the membrane revealed by quick-freezing and freeze-fracture replica labeling
    (2015)
  • 凍結割断レプリカ標識法によるホスホイノシチド PI(3, 5)P2の局在解析
    (第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会 合同大会 2015)
  • 出芽酵母液胞断片化過程におけるホスファチジルイノシトール-3,5-二リン酸の可視化解析
    (第87回日本生化学会大会 2014)
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Professional career (1)：
  • 博士(薬学) (東京大学)
Work history (4)：
  • 2014/10 - 現在 The University of Tokyo Graduate School of Pharmaceutical Sciences
  • 2012/04 - 2014/09 Nagoya University Graduate School of Medicine
  • 2011/10 - 2012/03 Nagoya University Graduate School of Medicine
  • 2010/04 - 2011/09 The University of Tokyo Graduate School of Pharmaceutical Sciences
Awards (1)：
  • 2022/10 - Ιnternational Society for Molecular Neurodegeneration ISMND2022 Poster Award Pathological roles of microglial gene INPP5D in a mouse model of Alzheimer disease
Association Membership(s) (3)：
THE JAPANESE ASSOCIATION OF ANATOMISTS ,  THE JAPANESE BIOCHEMICAL SOCIETY ,  日本認知症学会
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