Art

J-GLOBAL ID：201502200740458254   Reference number：15A0744003

Anti-biofilm activity and synergism of novel thiazole compounds with glycopeptide antibiotics against multidrug-resistant Staphylococci

多剤耐性ブドウ球菌に対する新規チアゾール化合物の抗バイオフィルム活性と糖ペプチド抗生物質との相乗性

Author (4)： MOHAMMAD Haroon (Purdue Univ. Coll. of Veterinary Medicine, IN, USA) ,  MAYHOUB Abdelrahman S (Al Azhar Univ., Cairo, EGY) ,  CUSHMAN Mark (Purdue Univ. Coll. of Pharmacy and the Purdue Center for Cancer Res., IN, USA) ,  SELEEM Mohamed N (Purdue Univ. Coll. of Veterinary Medicine, IN, USA)
Material： Journal of Antibiotics (Web)  (J Antibiot (Web))
Volume： 68  Issue： 4  Page： 259-266 (WEB ONLY)  Publication year： Apr. 2015 
JST Material Number： U0320A  ISSN： 0021-8820  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： multiple drug resistance ,...
Semi thesaurus term： VRSA ,...

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JST classification (1)： Basic research of antibiotics acting on pathogenic organisms  (GX05020C)

Substance index (2)： 2-(4-Butylphenyl)5-[2-(guanidinoimino)ethyl]-4-methylthiazole ,  2-(1,1′-Biphenyl-4-yl)5-[2-(guanidinoimino)ethyl]-4-methylthiazole

Reference (41)：

• CDC. Antibiotic Resistance Threats in the United States, 2013, 1-114 (Centers for Disease Control and Prevention, Atlanta, GA, USA, 2013).
• Moran, G. J. et al. Methicillin-resistant S. aureus infections among patients in the emergency department. New Engl. J. Med. 355, 666-674 (2006).
• Wang, R. et al. Staphylococcus epidermidis surfactant peptides promote biofilm maturation and dissemination of biofilm-associated infection in mice. J. Clin. Invest. 121, 238-248 (2011).
• Davies D. Understanding biofilm resistance to antibacterial agents. Nat. Rev. Drug Discov. 2003; 2: 114-122.
• Mah, T. F. & O'Toole, G. A. Mechanisms of biofilm resistance to antimicrobial agents. Trends Microbiol. 9, 34-39 (2001).

Terms in the title (6)： 多剤耐性 ,  ブドウ球菌 ,  チアゾール化合物 ,  バイオフィルム ,  活性 ,  糖ペプチド抗生物質