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J-GLOBAL ID：201502201266245446   Reference number：15A1169651

Short CCG repeat in huntingtin gene is an obstacle for replicative DNA polymerases, potentially hampering progression of replication fork

ハンチンチン遺伝子に含まれる短いCCGリピートは複製型DNAポリメラーゼの障害であり,複製フォークの進行を阻害する性質を持つ

Author (7)： LE Hang Phuong (Div. of Systems Biology, Graduate School of Biological Sciences, Nara Inst. of Sci. and Technol., Ikoma, 630-0192 ...) ,  MASUDA Yuji ,  TSURIMOTO Toshiki (Dep. of Biology, School of Sciences, Kyushu Univ., Fukuoka, 812-8581, JPN) ,  MAKI Satoko (Div. of Systems Biology, Graduate School of Biological Sciences, Nara Inst. of Sci. and Technol., Ikoma, 630-0192 ...) ,  KATAYAMA Tsutomu (Dep. of Molecular Biology, Graduate School of Pharmaceutical Sciences, Kyushu Univ., Fukuoka, 812-8582, JPN) ,  FURUKOHRI Asako (Div. of Systems Biology, Graduate School of Biological Sciences, Nara Inst. of Sci. and Technol., Ikoma, 630-0192 ...) ,  MAKI Hisaji (Div. of Systems Biology, Graduate School of Biological Sciences, Nara Inst. of Sci. and Technol., Ikoma, 630-0192 ...)
Material： Genes to Cells  (Genes Cells)
Volume： 20  Issue： 10  Page： 817-833  Publication year： Oct. 2015 
JST Material Number： W0935A  ISSN： 1356-9597  CODEN： GECEFL  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： *gene ,...
Semi thesaurus term： *trinucleotide repeat

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JST classification (1)： Gene replication  (EC02030F)

Reference (50)：

• Balakumaran, B.S., Freudenreich, C.H. & Zakian, V.A. (2000) CGG/CCG repeats exhibit orientation-dependent instability and orientation-independent fragility in Saccharomyces cerevisiae. Hum. Mol. Genet. 9, 93-100.
• Bermudez, V.P., Farina, A., Raghavan, V., Tappin, I. & Hurwitz, J. (2011) Studies on human DNA polymerase epsilon and GINS complex and their role in DNA replication. J. Biol. Chem. 286, 28963-28977.
• Bujalowski, W. & Lohman, T.M. (1986) Escherichia coli single-strand binding protein forms multiple, distinct complexes with single-stranded DNA. Biochemistry 25, 7799-7802.
• Butland, G., Peregrin-Alvarez, J.M., Li, J. et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433, 531-537.
• Cleary, J.D., Nichol, K., Wang, Y.H. & Pearson, C.E. (2002) Evidence of cis-acting factors in replication-mediated trinucleotide repeat instability in primate cells. Nat. Genet. 31, 37-46.

Terms in the title (7)： ハンチンチン ,  遺伝子 ,  DNAポリメラーゼ ,  障害 ,  複製フォーク ,  阻害 ,  性質