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J-GLOBAL ID：201502201970347016   Reference number：15A0184882

Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

多価N-アセチルガラクトサミン共役siRNAは肝細胞に局在化して,頑丈なRNAi仲介遺伝子サイレンシングを引き起こす

Author (25)： NAIR Jayaprakash K. (Alnylam Pharmaceuticals, Massachusetts, USA) ,  WILLOUGHBY Jennifer L. S. (Alnylam Pharmaceuticals, Massachusetts, USA) ,  CHAN Amy (Alnylam Pharmaceuticals, Massachusetts, USA) ,  CHARISSE Klaus (Alnylam Pharmaceuticals, Massachusetts, USA) ,  ALAM Md. Rowshon (Alnylam Pharmaceuticals, Massachusetts, USA) ,  WANG Qianfan (Alnylam Pharmaceuticals, Massachusetts, USA) ,  HOEKSTRA Menno (Leiden Academic Center for Drug Res., Leiden, NLD) ,  KANDASAMY Pachamuthu (Alnylam Pharmaceuticals, Massachusetts, USA) ,  KEL'IN Alexander V. (Alnylam Pharmaceuticals, Massachusetts, USA) ,  MILSTEIN Stuart (Alnylam Pharmaceuticals, Massachusetts, USA) ,  TANEJA Nate (Alnylam Pharmaceuticals, Massachusetts, USA) ,  O'SHEA Jonathan (Alnylam Pharmaceuticals, Massachusetts, USA) ,  SHAIKH Sarfraz (Alnylam Pharmaceuticals, Massachusetts, USA) ,  ZHANG Ligang (Alnylam Pharmaceuticals, Massachusetts, USA) ,  VAN DER SLUIS Ronald J. (Leiden Academic Center for Drug Res., Leiden, NLD) ,  JUNG Michael E. (Univ. California, California, USA) ,  AKINC Akin (Alnylam Pharmaceuticals, Massachusetts, USA) ,  HUTABARAT Renta (Alnylam Pharmaceuticals, Massachusetts, USA) ,  KUCHIMANCHI Satya (Alnylam Pharmaceuticals, Massachusetts, USA) ,  FITZGERALD Kevin (Alnylam Pharmaceuticals, Massachusetts, USA) ,  ZIMMERMANN Tracy (Alnylam Pharmaceuticals, Massachusetts, USA) ,  VAN BERKEL Theo J. C. (Leiden Academic Center for Drug Res., Leiden, NLD) ,  MAIER Martin A. (Alnylam Pharmaceuticals, Massachusetts, USA) ,  RAJEEV Kallanthottathil G. (Alnylam Pharmaceuticals, Massachusetts, USA) ,  MANOHARAN Muthiah (Alnylam Pharmaceuticals, Massachusetts, USA)
Material： Journal of the American Chemical Society  (J Am Chem Soc)
Volume： 136  Issue： 49  Page： 16958-16961  Publication year： Dec. 10, 2014 
JST Material Number： C0254A  ISSN： 0002-7863  CODEN： JACSAT  Document type： Article
Article type： 短報  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *siRNA ,  hepatocyte ,  *gene expression ,  Gene Therapy ,  membrane transport receptor ,  oligonucleotide ,  solid phase synthesis ,  RNA interference ,  drug delivery system ,  biodistribution ,  nuclease ,  Mus musculus ,  *Gene Silencing ,  aliphatic aldehyde ,  aliphatic carboxylic acid ,  carboxamide ,  aminoalcohol ,  polyol ,  Asialoglycoprotein Receptor ,  *molecular genetic phenomenon ,  Heredity ,  Myomorpha
Semi thesaurus term： drug delivery system

JST classification (2)： Gene manipulation  (EC02050B) ,  Pharmaceutical preparations in general  (GY02010Z)

Substance index (1)： N-Acetylgalactosamine

Terms in the title (9)： 多価 ,  N-アセチルガラクトサミン ,  共役 ,  siRNA ,  肝細胞 ,  局在化 ,  RNAi ,  仲介 ,  遺伝子サイレンシング