Art

J-GLOBAL ID：201502204913907420   Reference number：15A1242976

ダウン症モデルマウスにおける神経発生異常の分子基盤の解析

Author (1)： SANADA YOSHIKADO (東大 大学院理学系研究科 遺伝子実験施設)
Material： 第一三共生命科学研究振興財団研究報告集
Volume： 31  Page： 119-127  Publication year： Oct. 21, 2015 
JST Material Number： L2409A  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *Down Syndrome ,...
Semi thesaurus term： *DYRK1A ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=15A1242976&from=J-GLOBAL&jstjournalNo=L2409A") }}

JST classification (2)： Congenital diseases,deformities in general.  (GD03010V) ,  Nervous system in general  (EJ12010J)

Reference (13)：

• Canfield M. A., Honein M. A., Yuskivm N., Xing J., Mai C. T., Collins J. S., Devine O., Petrini J., Ramadhani T. A., Hobbs C. A. and Kirby R. S. : National estimates and race/ethnic-specific variation of selected birth defects in the United States, 1999-2001. Birth Defects Res. A Clin. Mol. Teratol., 76: 747-756, 2006.
• Chapman R. S. and Hesketh L. J. : Behavioral phenotype of individuals with Down syndrome. Ment. Retard. Dev. Disabil. Res. Rev., 6: 84 -95, 2000.
• Griffin W. S., Stanley L. C., Ling C., White L., MacLeod V., Perrot L. J., White C. L. 3rd and Araoz C. : Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc. Natl. Acad. Sci. USA, 86 : 7611-7615, 1989.
• Guidi S., Bonasoni P., Ceccarelli C., Santini D., Gualtieri F., Ciani E. and Bartesaghi R. : Neurogenesis impairment and increased cell death reduce total neuron number in the hippocampal region of fetuses with Down syndrome. Brain Pathol., 18 :180-197, 2008.
• Mann D. M. A., Yates P. O., Marcyniuk B. and Ravindra C. R. : Loss of neurons from cortical and subcortical areas in Down's syndrome patients at middle age : quantitative comparisons with younger Down's patients and patients with Alzheimer's disease. J. Neurol. Sci., 80 : 79-89, 1987.

Terms in the title (7)： ダウン症 ,  モデルマウス ,  神経 ,  発生異常 ,  分子 ,  基盤 ,  解析