Art

J-GLOBAL ID：201502206514231440   Reference number：15A1281213

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

血圧:複数祖先集団のゲノムワイド関連解析から血圧を左右する12の遺伝的座位が同定され,DNAメチル化の役割が示唆された

Author (40)： KATO Norihiro (National Center for Global Health and Medicine, Tokyo, JPN) ,  TAKEUCHI Fumihiko (National Center for Global Health and Medicine, Tokyo, JPN) ,  AKIYAMA Koichi (National Center for Global Health and Medicine, Tokyo, JPN) ,  ISONO Masato (National Center for Global Health and Medicine, Tokyo, JPN) ,  SHIMOKAWA Kazuro (National Center for Global Health and Medicine, Tokyo, JPN) ,  LOH Marie (Univ. Oulu, Oulu, FIN) ,  JARVELIN Marjo-Riitta (Univ. Oulu, Oulu, FIN) ,  LOH Marie (Imperial Coll. London, London, GBR) ,  ZHANG Weihua (Imperial Coll. London, London, GBR) ,  LEHNE Benjamin (Imperial Coll. London, London, GBR) ,  SCOTT William R (Imperial Coll. London, London, GBR) ,  CAMPANELLA Gianluca (Imperial Coll. London, London, GBR) ,  CHADEAU-HYAM Marc (Imperial Coll. London, London, GBR) ,  AFZAL Uzma (Imperial Coll. London, London, GBR) ,  GREWAL Jagvir (Imperial Coll. London, London, GBR) ,  VINEIS Paolo (Imperial Coll. London, London, GBR) ,  ELLIOTT Paul (Imperial Coll. London, London, GBR) ,  CHAMBERS John C (Imperial Coll. London, London, GBR) ,  LOH Marie (Agency for Sci., Technol. and Res. (A*STAR), Singapore) ,  VERWEIJ Niek (Univ. Groningen, Groningen, NLD) ,  LEACH Irene Mateo (Univ. Groningen, Groningen, NLD) ,  VAN GILST Wiek H (Univ. Groningen, Groningen, NLD) ,  VAN VELDHUISEN Dirk J (Univ. Groningen, Groningen, NLD) ,  VAN DER HARST Pim (Univ. Groningen, Groningen, NLD) ,  WANG Xu (Saw Swee Hock School of Public Health, National Univ. Singapore and National Univ. Health System, Singapore) ,  CHEN Peng (Saw Swee Hock School of Public Health, National Univ. Singapore and National Univ. Health System, Singapore) ,  KHOR Chiea-Chuen (Saw Swee Hock School of Public Health, National Univ. Singapore and National Univ. Health System, Singapore) ,  CHENG Ching-Yu (Saw Swee Hock School of Public Health, National Univ. Singapore and National Univ. Health System, Singapore) ,  KOH Woon-Puay (Saw Swee Hock School of Public Health, National Univ. Singapore and National Univ. Health System, Singapore) ,  LEE Jeannette (Saw Swee Hock School of Public Health, National Univ. Singapore and National Univ. Health System, Singapore) ,  VAN DAM Rob M (Saw Swee Hock School of Public Health, National Univ. Singapore and National Univ. Health System, Singapore) ,  LIU Jianjun (Saw Swee Hock School of Public Health, National Univ. Singapore and National Univ. Health System, Singapore) ,  TEO Yik-Ying (Saw Swee Hock School of Public Health, National Univ. Singapore and National Univ. Health System, Singapore) ,  TAI E Shyong (Saw Swee Hock School of Public Health, National Univ. Singapore and National Univ. Health System, Singapore) ,  ZHANG Weihua (Ealing Hospital National Health Serv. (NHS) Trust, Middlesex, GBR) ,  TAN Sian-Tsung (Ealing Hospital National Health Serv. (NHS) Trust, Middlesex, GBR) ,  AFZAL Uzma (Ealing Hospital National Health Serv. (NHS) Trust, Middlesex, GBR) ,  GREWAL Jagvir (Ealing Hospital National Health Serv. (NHS) Trust, Middlesex, GBR) ,  MILLS Rebecca (Ealing Hospital National Health Serv. (NHS) Trust, Middlesex, GBR) ,  KOONER Jaspal S (Ealing Hospital National Health Serv. (NHS) Trust, Middlesex, GBR)
Material： Nature Genetics  (Nat Genet)
Volume： 47  Issue： 11  Page： 1282-1293  Publication year： Nov. 2015 
JST Material Number： W0430A  ISSN： 1061-4036  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： methylation ,  *gene locus ,  human(primates) ,  *blood pressure ,  Genome-Wide Association Study ,  *single nucleotide polymorphism ,  cardiovascular disease ,  gene ,  blood vessel ,  smooth muscle ,  kidney
Semi thesaurus term： *DNA Methylation ,  *SNP ,  Muscle, Smooth, Vascular

JST classification (1)： Genetic variation  (EC01030Y)

Terms in the title (7)： 血圧 ,  集団 ,  ゲノムワイド関連解析 ,  座位 ,  同定 ,  DNAメチル化 ,  役割