Art

J-GLOBAL ID：201502208239402194   Reference number：15A0943022

TET2 as a gatekeeper for hematologic malignancies

造血器腫瘍におけるTET2のゲートキーパーとしての役割

Author (3)： MUTO HIDEHARU (筑波大学医学医療系血液内科) ,  SAKATA(YANAGIMOTO) MAMIKO (筑波大学医学医療系血液内科) ,  CHIBA SHIGERU (筑波大学医学医療系血液内科)
Material： 臨床血液  (Japanese Journal of Clinical Hematology)
Volume： 56  Issue： 6  Page： 651-656 (J-STAGE)  Publication year： 2015 
JST Material Number： Z0688A  ISSN： 0485-1439  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *hematologic disease ,...
Semi thesaurus term： DNA demethylation ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=15A0943022&from=J-GLOBAL&jstjournalNo=Z0688A") }}

JST classification (2)： Carcinogenic mechanisms and factors  (GE02020C) ,  Blood cell tumors(=neoplasms)  (GK04000M)

Reference (34)：

• 1) Lorsbach RB, Moore J, Mathew S, Raimondi SC, Mukatira ST, Downing JR. TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23). Leukemia. 2003; 17: 637-641.
• 2) Mohr F, Döhner K, Buske C, Rawat VP. TET genes: new players in DNA demethylation and important determinants for stemness. Exp Hematol. 2011; 39: 272-281.
• 3) Ito S, D'Alessio AC, Taranova OV, Hong K, Sowers LC, Zhang Y. Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature. 2010; 466: 1129-1133.
• 4) Tahiliani M, Koh KP, Shen Y, et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science. 2009; 324: 930-935.
• 5) Branco MR, Ficz G, Reik W. Uncovering the role of 5-hydroxymethylcytosine in the epigenome. Nat Rev Genet. 2011; 13: 7-13.

Terms in the title (3)： 造血器腫瘍 ,  TET2 ,  役割