Art

J-GLOBAL ID：201502208432621529   Reference number：15A0977921

Novel metal chelating molecules with anticancer activity. Striking effect of the imidazole substitution of the histidine-pyridine-histidine system

抗癌活性を持つ新規金属キレート化分子 ヒスチジン-ピリジン-ヒスチジン系のイミダゾール置換の顕著な効果

Author (19)： ALI Taha F.S. (Dep. of Bioorganic Medicinal Chemistry, Fac. of Life Sciences, Kumamoto Univ., 5-1 Oe-honmachi, Chuo-ku, Kumamoto ...) ,  IWAMARU Kana (Dep. of Bioorganic Medicinal Chemistry, Fac. of Life Sciences, Kumamoto Univ., 5-1 Oe-honmachi, Chuo-ku, Kumamoto ...) ,  CIFTCI Halil Ibrahim (Dep. of Bioorganic Medicinal Chemistry, Fac. of Life Sciences, Kumamoto Univ., 5-1 Oe-honmachi, Chuo-ku, Kumamoto ...) ,  KOGA Ryoko (Dep. of Bioorganic Medicinal Chemistry, Fac. of Life Sciences, Kumamoto Univ., 5-1 Oe-honmachi, Chuo-ku, Kumamoto ...) ,  MATSUMOTO Masahiro (Dep. of Bioorganic Medicinal Chemistry, Fac. of Life Sciences, Kumamoto Univ., 5-1 Oe-honmachi, Chuo-ku, Kumamoto ...) ,  OBA Yasunori (Dep. of Bioorganic Medicinal Chemistry, Fac. of Life Sciences, Kumamoto Univ., 5-1 Oe-honmachi, Chuo-ku, Kumamoto ...) ,  KUROSAKI Hiromasa (Coll. of Pharmacy, Kinjo Gakuin Univ., 2-1723 Omori, Moriyama-ku, Nagoya, Aichi 463-8521, JPN) ,  FUJITA Mikako (Res. Inst. for Drug Discovery, School of Pharmacy, Kumamoto Univ., 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, JPN) ,  OKAMOTO Yoshinari (Dep. of Bioorganic Medicinal Chemistry, Fac. of Life Sciences, Kumamoto Univ., 5-1 Oe-honmachi, Chuo-ku, Kumamoto ...) ,  UMEZAWA Kazuo (Dep. of Medical Cell Biology, Inst. of Molecular Embryology and Genetics, Kumamoto Univ., Kumamoto 860-0811, JPN) ,  NAKAO Mitsuyoshi (Dep. of Molecular Target Medicine Screening, School of Medicine, Aichi Medical Univ., Nagakute, Aichi 480-1195, JPN) ,  HIDE Takuichiro (Dep. of Neurosurgery, Fac. of Medicine, Kumamoto Univ., 1-1-1 Honjo Chuo-ku, Kumamoto 860-8556, JPN) ,  MAKINO Keishi (Dep. of Neurosurgery, Fac. of Medicine, Kumamoto Univ., 1-1-1 Honjo Chuo-ku, Kumamoto 860-8556, JPN) ,  KURATSU Jun-ichi (Dep. of Neurosurgery, Fac. of Medicine, Kumamoto Univ., 1-1-1 Honjo Chuo-ku, Kumamoto 860-8556, JPN) ,  ABDEL-AZIZ Mohamed (Dep. of Medicinal Chemistry, Fac. of Pharmacy, Minia Univ., 61519 Minia, Egypt) ,  ABUO-RAHMA Gamal El-Din A.A. (Dep. of Medicinal Chemistry, Fac. of Pharmacy, Minia Univ., 61519 Minia, Egypt) ,  BESHR Eman A.M. (Dep. of Medicinal Chemistry, Fac. of Pharmacy, Minia Univ., 61519 Minia, Egypt) ,  BESHR Eman A.M. (Dep. of pharmaceutical Chemistry, Coll. of Pharmacy, Umm Al-Qura Univ., Makkah 21955, Saudi Arabia) ,  OTSUKA Masami (Dep. of Bioorganic Medicinal Chemistry, Fac. of Life Sciences, Kumamoto Univ., 5-1 Oe-honmachi, Chuo-ku, Kumamoto ...)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 23  Issue： 17  Page： 5476-5482  Publication year： Sep. 01, 2015 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *antitumor action ,  *chelation ,  *amino acid residue ,  *nitrogen heterocyclic compound ,  human(primates) ,  adenocarcinoma ,  pancreatic tumor ,  tumor cell ,  induction ,  brain tumor ,  cultured cell ,  in vitro experiment ,  molecular genetic phenomenon ,  proton magnetic resonance ,  13C NMR ,  fast atom bombardment mass spectrometry ,  ATR spectroscopy ,  FTIR spectroscopy ,  radical ,  aromatic compound
Semi thesaurus term： 1H-NMR ,  AsPC-1 cell ,  ATR FTIR ,  C13NMR ,  DNA Cleavage ,  fast atom bombardment mass spectroscopy ,  In vitro study ,  U251 cell ,  U87 cell ,  apoptosis induction ,  *Imidazoles ,  *histidine residue ,  *Pyridines ,  *anticancer activity ,  Pancreatic adenocarcinoma

JST classification (3)： Nitrogen heterocycles in general  (CF07040G) ,  Synthesis of drugs  (GV01030F) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (3)： Trityl radical ,  1-Trityl-[N^α,N^α′-[[4-(dimethylamino)pyridine-2,6-diyl]bismethylene]bis(L-histidine methyl)] ester ,  2,2′-[4-(Dimethylamino)-2,6-pyridinediylbisimino]bis[(2S)-3-(1-trityl-1H-imidazole-4-yl)propanoic acid methyl] ester

Terms in the title (7)： 抗癌活性 ,  金属キレート ,  分子 ,  ヒスチジン ,  ピリジン ,  イミダゾール ,  置換